What Are the Symptoms of Chronic Idiopathic Urticaria?

Ruifei, a light red oval film-coated tablet, removes wet white to off-white drugs after coating, and is suitable for reducing the symptoms caused by seasonal allergic rhinitis and chronic idiopathic urticaria.

Rafi

Right!

Ruifei, a light red oval film-coated tablet, removes wet white to off-white drugs after coating, and is suitable for reducing the symptoms caused by seasonal allergic rhinitis and chronic idiopathic urticaria.

Chinese name

Rafi

Foreign name

Fexofenadine Hydrochloride Tablets

Specifications

60mg

Functional indication

This product is suitable for reducing the symptoms caused by seasonal allergic rhinitis and chronic idiopathic urticaria.

[Chinese name] Rui Fei ^[1]

This product is suitable for reducing the symptoms caused by seasonal allergic rhinitis and chronic idiopathic urticaria.

Pharmacological effects: This product is a second-generation H1 receptor antagonist, a carboxylated metabolite of terfenadine, which selectively blocks the H1 receptor, and has good antihistamine effects, but no antihistamines. -5 serotonin, anticholinergic and antiadrenalin effects. Animal studies have shown that fexofenadine can selectively inhibit antigen-induced bronchospasm in sensitized guinea pigs; it can inhibit the release of histamine from peritoneal mast cells in rats; it does not have the physiological effects of parasympathetic society or alpha * adrenaline Receptor blocking effect; and fexofenadine does not have sedative effects and other central nervous system effects. Therefore, it cannot pass through the blood-brain barrier, does not block the potassium channels of animal cardiomyocytes; does not affect the potential repolarization of the patient's cardiac function, does not extend the QT interval, and produces cardiotoxicity.

Toxicological effects: Acute toxicity test results show that fexofenadine has low oral toxicity. The oral LD50 of mice and rats is greater than 5000mg / kg, and the oral LD50 of dogs is greater than 2000mg / kg. The results of the subacute toxicity test showed that rats continuously took 35 mg / kg of this product for 28 days and dogs continued to take 100 mg / kg of this product for 28 days. No adverse reactions were observed.

Fexofenadine does not undergo biotransformation by the liver, so it does not interact with drugs that rely on liver metabolism.

(1) 15 minutes before taking fexofenadine hydrochloride, the use of antacids containing aluminum or magnesium hydride gel will reduce the bioavailability of fexofenadine, so the time of administration should be 2 hours apart .

(2) Studies show that it is safe and effective to give healthy volunteers fexofenadine 120 mg twice daily combined with erythromycin 500 mg three times a day or ketoconazole 400 mg once a day. When erythromycin or ketoconazole is used in combination, the plasma concentration of fexofenadine will be increased by two times, but the incidence of adverse reactions will not be increased. For example, the QT interval will be prolonged. And ketoconazole had no effect on pharmacokinetics.

[Drug composition]

Fexofenadine hydrochloride. Chemical name: , dimethyl-4- [1-hydroxy-4- [4- (hydroxydiphenylmethyl) -1-pyridine] butyl]

[Medication for pregnant women]

At present, there is no safety test data for pregnant women to use this product, so pregnant women are generally not suitable to use this product. If the disease is necessary, they should be used with caution after weighing the advantages and disadvantages. There are currently no safety information on the use of this product by lactating women, but many drugs are excreted from milk. Some young children may have some adverse reactions after taking the drug-containing milk. Therefore, if the disease is necessary for lactating women, they should weigh the pros and cons and use it with caution.

[Child medication]

The safety and effectiveness of this product for children under 6 years have not been established.

[Medication for elderly patients]

In a placebo-controlled clinical trial, 42 elderly patients aged 60 to 68 years were given 20 mg to 240 mg of fexofenadine 2 times a day for 2 weeks. The adverse reactions were similar to those of patients under 60 years old. Produces similarities. No adjustment is needed for elderly patients.

This product is taken orally for adults and children over 12 years of age and the elderly: the recommended dose for seasonal allergic rhinitis is 120 mg (2 tablets) once a day, and the recommended dose for chronic urticaria is 180 mg (3 tablets) once a day. The first dose of patients with low renal function is 60mg (1 tablet) once a day. The elderly and patients with liver damage do not need to adjust the dose. Children 6 to 11 years of age: The recommended dose for seasonal allergic rhinitis and chronic idiopathic urticaria is 30 mg (tablets) once a day, and the first dose for patients with renal insufficiency is 30 mg (half tablet) once a day.

Store below 25 ° C in a dry place.

Hepatic dysfunction does not need to be reduced, and patients with renal dysfunction need to be halved.