What Is Bradykinin?

Bradykinin (BK) is a 9-peptide substance with cardioprotective effect, which can reduce the infarcted area of acute myocardial ischemia-reperfusion myocardium. Medicine has confirmed that BK also has a delayed protective effect on myocardial ischemia-reperfusion myocardium.

Bradykinin

Bradykinin (BK) is a

Bradykinin Chinese name: Bradykinin

English bradykinin, brady means slow.

1. Linear 9 peptide. Kind of kallikrein. Its structural sequence is Arg, Pro, Pro, Gly, Phe, Ser, Pro, Phe, Arg. Has Shuxue

Decrease: Plasma bradykinin reduction seen in

Studies have found that BK can increase the content of ATP and creatine phosphate in the early stage of myocardial ischemia, reduce the decomposition of glycogen, and reduce the production of lactic acid.

Bradykinin

And improve the anti-ischemic ability of myocardium, and this result also partially explained the protective effect of BK on syncope myocardium that we previously found. When the myocardial ischemia was 40min, there was no significant difference in the energy metabolism index of each group, which may be The excessive myocardial ischemia caused the depletion of myocardial energy reserve and the cessation of myocardial metabolic activity. After reperfusion, the content of ATP, creatine phosphate and glycogen in the myocardium of the BK group was higher than that of the control group again. Compared with the control group, the content was significantly reduced, which may be related to the previously found that BK pretreatment can delay the ischemia-reperfusion myocardial infarction area. It is not difficult to understand that the number of surviving myocardium in the myocardial ischemic area of the BK group was significantly higher than In the control group, the content of ATP, creatine phosphate and glycogen must be higher than that of the control group, while the content of lactic acid is lower than the control group. But why BK can improve energy metabolism in the early stage of ischemia needs further exploration.