What Is Chronic Mucocutaneous Candidiasis?

Chronic mucosal skin candidiasis refers to immunodeficiency of T lymphocytes, which is a primary cellular immunodeficiency disease. This disease is an autosomal recessive disease. Clinical manifestations are chronic recurrent Candida infections of the skin, mucous membranes and fingernails. May be combined with idiopathic endocrine abnormalities.

Basic Information

English name

chronic dermatomucoso candidiasis

Visiting department

dermatology

Multiple groups

baby

Common locations

Skin, mucous membranes and fingernails

Common causes

Autosomal recessive disease

Common symptoms

Skin damage to the face and extremities, with slightly raised erythema, with keratinosis, scales and candida granulomas, swelling, etc.

Etiology of chronic mucosal skin candidiasis

This disease is an autosomal recessive disease.

Clinical manifestations of chronic mucosal skin candidiasis

Patients may develop chronic recurrent Candida infections of the skin, mucous membranes and fingernails. Skin lesions are more common on the face and limbs, showing a slightly raised erythema with keratinosis, scales, and candida granulomas. Skin lesions on the face, forehead, and top of the head are often covered with keratinizing palate, which refers to Significant swelling around the nails, thick, twisted, and damaged decks. The internal organs are often not tired.

Examination of chronic mucosal skin candidiasis

Immunological examination

Most patients have T cell dysfunction, and the total number of lymphocytes, total number of T cells, and lymphocyte mitogens such as PHA are normal. There was no response to the delayed skin allergy test of Candida antigen, and the delayed skin allergy reaction to various other antigens was normal. The number of B cells and humoral immune function were normal, and the serum immunoglobulin content was normal.

2. Histological examination

Histological examination of skin lesions showed candida granuloma.

Treatment of chronic mucosal skin candidiasis

Diagnosis can be made based on medical history, clinical manifestations, and laboratory tests.

Complications of chronic mucosal skin candidiasis

The disease can be complicated by diabetes, hypoparathyroidism, Edison disease, iron deficiency anemia, vitamin A deficiency and other diseases.

Treatment of chronic mucosal skin candidiasis

General treatment of immunodeficiency diseases requires maintaining optimal health and nutritional status, managing the onset of infections, and preventing emotional problems related to the disease. Try to keep patients away from the infection and have your own bedroom. In the case of certain antibody functions, dead vaccines should be given regularly. The tooth is in need of treatment. Antibiotics are essential to control the onset of infections. The choice and dosage of antibiotics are the same as usual. Because immunodeficiency patients may quickly die from infections, when fever and other signs of infection appear, secondary manifestations of bacterial infections should be considered and antibacterial treatment should be started immediately. If the infection is not sensitive to the antibiotics originally selected, or if the infection is a rare microorganism, throat, blood, and other cultures should be performed before treatment.