What Is Foreign Body Granuloma?

Foreign body granulomatosis is an allergic reaction caused by a foreign body, which only occurs in people with a foreign body allergic quality. After various substances from non-organic tissues enter the human body, they can cause tissue reactions (skin foreign body reactions) in skin tissues, and their structure is a granulomatous inflammatory response.

Basic Information

English name

oreign body grannuloma

Visiting department

dermatology

Multiple groups

People with allergy to foreign bodies

Common locations

skin

Common causes

Metal fragments, non-metallic ore, glass, vegetable starch, chemical fiber, cotton silk material, parasitic larva, fungus, physical explosive dust, difficult to absorb medicinal oily or irritating chemicals or endogenous keratin Contents, cysts or teratoma rupture contents, tissue necrosis calcified deposits, etc.

Common symptoms

rash

Causes of foreign body granulomatosis

There are many types of substances that cause granulomatous reactions of skin foreign bodies. Broad foreign matter includes metal fragments, non-metallic ore, glass, vegetable starch, chemical fiber, cotton material, parasitic larvae, fungi, physical explosive dust, difficult to absorb medicinal oil or strong irritating chemicals or endogenous Sexual keratin, cyst or teratoma ruptured contents, tissue necrosis and calcified deposits, etc., can cause inflammatory granulomatous reactions.

Clinical manifestations of foreign body granulomatous

Foreign body granulomatosis is an allergic reaction caused by a foreign body, which occurs in people with allergic qualities of foreign bodies. It usually takes a long time for foreign matter to enter the body and the rash appears, which can range from months to years. For example, silicide (cement, sand, glass, etc.) can cause a rash reaction in about 10 years. Skin lesions vary according to the type, nature, and method of invasion. Pimples, nodules, plaques, pigmentation, inflammatory reactions, and infiltration of inflammatory cells are common. The local skin color can be red or purple, or normal skin color. The skin lesions are hard, and it is impossible to disappear on their own. A few of them can rupture and excrete foreign bodies or necrotic objects due to strong inflammation or tissue necrosis. Sometimes a hard mass or nodule can be formed by a subcutaneous implant (such as an injection of oil), which does not disappear or cause local atrophy for many years.

Foreign body granulomatous examination

Histopathological examination is as follows:

Typical foreign body reaction

Macrophages and foreign bodies Giant cells surround foreign bodies, and lymphoid cells and plasma cells infiltrate around them. Foreign bodies are still visible. Such as sutures, liquid paraffin oil, silicon salts, hair, etc. can cause foreign body reactions.

2. Foreign body allergic reaction

There may be tuberculous nodules composed of epithelial cells, giant cells and caseous necrosis may or may not be present, but the lack of foreign body swallowing or lack of cobalt beryllium or tattoo pigment can cause allergic reactions to foreign bodies.

3. Specific foreign body granuloma

For example, pigment granules can be seen in tattoo granuloma, and non-tuberculous granuloma can be seen in silicon granuloma, which is the inflammation infiltration of most macrophages and multinucleated cells, and needle-like silicon crystals with strong refractive properties can be seen.

Foreign body granulomatous diagnosis

According to clinical manifestations, skin lesion characteristics, and histopathological characteristics can be diagnosed.

Foreign body granulomatous treatment

Severe damage can be removed surgically, and liquid nitrogen cryotherapy can also be tried. If the damage is small without conscious symptoms and does not affect function, it can be left untreated.