What Is Hyperinsulinism?

English name: hyperinsulinemia

Hyperinsulinemia

English name: hyperinsulinemia

Chinese name: Hyperinsulinemia

Overview of Hyperinsulinemia

Explanation of terms: Acanthosis nigricans is caused by hyperinsulinemia. Too much insulin causes insulin to combine with insulin-like growth factor receptors on keratinocytes and fibroblasts, resulting in skin hyperplasia. Hyperinsulinemia is caused by increased insulin resistance due to insulin resistance caused by obesity.

After the famous American endocrinologist Reaven put forward the metabolic syndrome, hyperinsulinemia was widely valued.

Hypertension or obesity impairs the biological effects of insulin in patients with hypertension. At this time, the human body is resistant to insulin, and in order to maintain a more normal blood sugar level, their self-regulation mechanism causes their islet cells to secrete insulin several times or even ten times more than normal to lower blood sugar, which causes Has hyperinsulinemia. Hyperinsulinemia is defined as fasting insulin 85 pmol / L.

Hyperinsulinemia complications

Insulinemia is the common pathogenesis of coronary heart disease, hypertension, hyperlipidemia, type 2 diabetes, obesity, and stroke.

Hyperinsulinemia treatment

[Strengthening physical exercise]: Physical activity can increase tissue sensitivity to insulin, reduce weight, improve metabolism, reduce insulin resistance, relieve hyperinsulinemia, and reduce cardiovascular complications.

[Improve diet structure]: No matter in China or in the West, people's diet structure is mainly high in calories and high in fat. Excessive caloric intake over consumption will cause fat accumulation in the body and cause obesity. Therefore, the diet should be diversified to maintain nutritional balance and avoid excess nutrition.

If the disease is to be treated with medication, it must be under the guidance of a doctor. Take medications while monitoring to adjust hormone levels to within the health index range. ^[1]

Hyperinsulinemia is a cardiovascular hazard

The insensitivity of the surrounding tissue to insulin weakens the effect of insulin in the muscle and inhibits the lipolysis of adipose tissue. Insulin resistance in adipose tissue leads to increased free fatty acid and triglyceride concentrations in the blood. High triglycerides and low density lipoproteins increase the risk of cardiovascular disease. Low-density lipoprotein can penetrate into the intima of coronary arteries and other arteries, forming atherosclerotic plaques and blocking blood vessels. Cardiac and cerebrovascular diseases occur prematurely in diabetic patients with dyslipidemia, especially in women. Women's estrogen protects the heart and blood vessels, while diabetes makes the protective effects of estrogen disappear. Hyperinsulinemia also damages vascular endothelial cells, causes platelets to aggregate, and makes blood clot easily. Insulin can also activate the sympathetic nervous system in patients with insulin resistance, cause vasospasm, increase resistance, and promote the occurrence of essential hypertension. At the same time, the heart will also be affected, resulting in abnormal ventricular structure, heart failure and even failure.

As early as 1988, the medical community noticed the relationship between hyperinsulinemia and heart disease. At that time, this type of metabolic abnormality was called syndrome X. In the 21st century, Syndrome X was officially renamed Metabolic Syndrome. Metabolic syndrome includes abnormal blood sugar, hypertension, obesity or central obesity, and dyslipidemia.