What Is Intrinsic Asthma?

Definition of asthma in the 2014 GINA guidelines: Asthma is a heterogeneous disease, often characterized by chronic airway inflammation, and includes a history of respiratory symptoms that change over time, such as wheezing, shortness of breath, chest tightness, and cough. Air flow is restricted. It is clinically found that the clinical characteristics of asthma and airway inflammation have different phenotypes, such as menstrual asthma, which is one of the clinical characteristics phenotypes, which is a special type of asthma.

Basic Information

English name

menstrual asthma

Visiting department

Respiratory

Multiple groups

Women of childbearing age

Common causes

Increased endogenous prostaglandin secretion, decreased progesterone and estrogen levels in the body, caused by dysmenorrhea, etc.

Common symptoms

Wheezing, shortness of breath, chest tightness, and cough

Causes of menstrual asthma

Specific types of asthma that use menstruation as a trigger, current research speculates that:

1. Increased endogenous prostaglandin secretion (increased PGF2a);

2. Decreased progesterone and estrogen levels in the body;

3. Dysmenorrhea;

4. There is a change in the immune status of the menstrual period before menstruation.

Clinical manifestations of menstrual asthma

The main clinical characteristics of menstrual asthma patients are that the symptoms of bronchial asthma appear asthma or worsen in the premenstrual period or menstrual period, and the respiratory symptoms are similar to other types of asthma.

Menstrual asthma test

1. Prostaglandin F2 increased significantly.

2. Forced vital capacity: Menstrual asthma women's PEF decreases during menstruation, but the decline is not serious. PEF may decrease slightly in the early morning, and severe premenstrual pre-menstrual asthma patients may have a significant decrease in pre-menstrual PEF and have no response to conventional treatment. Airway responsiveness measurement Airway responsiveness was measured in well-controlled asthma women before and after the menstrual cramps, respectively. As a result, there was no significant difference in airway responsiveness or FEV1.

Menstrual Asthma Diagnosis

Diagnosis can be made where regular asthma occurs before and after menstruation.

Menstrual Asthma Treatment

1. For general authors, inhalable 2 receptor agonists and corticosteroids, oral theophylline.

2. For more serious authors, oxygen therapy and magnesium sulfate can be added. Aminophylline is administered intravenously under intravenous monitoring of blood concentration, and glucocorticoids are given intravenously.

3. For critically ill authors, artificial ventilation should be used in addition to drugs. For women with premenstrual asthma who are ineffective for high-dose glucocorticoids and other conventional treatments, adding progesterone to the treatment can improve the decline of premenstrual PEF and reduce the daily hormone dose, which can help treat premenstrual severe Asthma attack.