What Is Ipriflavone?
Isoflavones are phenolic compounds based on the benzophenone ring after cinnamic coenzyme A side chain extension during the phenylalanine metabolism of plants. Plant secondary metabolites. Flavonoids are an aromatic oxygen-containing heterocyclic compound, isomers of flavonoids. The refined isoflavones are flaky or needle-like crystals. Generally colorless, but with the increase of hydroxyl groups, it can be yellow to dark yellow. It is a pigment widely distributed in higher plants. Some isoflavones are phytoalexins, and some are useful in the treatment of cardiovascular disease.
- Chinese name
- Isoflavones
- Foreign name
- Isoflavone
- CAS number
- 574-12-9
- Alias
- Isoflavones
- Isoflavones are phenolic compounds based on the benzophenone ring after cinnamic coenzyme A side chain extension during the phenylalanine metabolism of plants. Plant secondary metabolites. Flavonoids are an aromatic oxygen-containing heterocyclic compound, isomers of flavonoids. The refined isoflavones are flaky or needle-like crystals. Generally colorless, but with the increase of hydroxyl groups, it can be yellow to dark yellow. It is a pigment widely distributed in higher plants. Some isoflavones are phytoalexins, and some are useful in the treatment of cardiovascular disease.
About Isoflavones
- Isoflavones are one of the flavonoids, which are mainly found in leguminous plants. Soy isoflavones [1] are a class of secondary metabolites formed during the growth of soybeans. Because it is extracted from plants and has a similar structure to estrogen, it is called phytoestrogens.
- The estrogen effect of soy isoflavones affects hormone secretion, metabolic biological activity, protein synthesis, and growth factor activity. It is a natural cancer chemopreventive agent.
- Probiotic soy isoflavones are bioactive substances refined from non-GMO soybeans. They are a natural nutritional factor with a variety of important physiological activities. They are pure natural phytoestrogens that are easily absorbed by the human body and can quickly replenish nutrition.
- Flavonoids
- In every 100 grams of soybean sample, 128 mg of isoflavones are contained. Traditionally, the isolated protein contains 102 mg of isoflavones, while soy milk contains 9.65 mg. Because soy milk contains 93.27% water, it is equivalent to every 100 grams of dry matter. 100 mg or more. Tofu contains 27.74 mg of isoflavones, and its dry matter contains more than 200 mg of isoflavones.
- Isoflavones are a weak phytoestrogen, soy is the only effective source of human isoflavones. In the case of strong physiological activity of estrogen, isoflavones can act as anti-estrogen, reducing the risk of estrogen-activated cancers such as breast cancer, and when women's menopausal levels decrease, the isoflavones can play a substitute role. Avoid menopausal symptoms such as hot flashes.
- Isoflavones have outstanding anti-cancer properties, can hinder the growth and spread of cancer cells, and only affect cancer cells, but have no effect on normal cells.
- Isoflavones are also effective antioxidants that prevent the generation of oxygen free radicals, which are a strong carcinogen. It can be seen that there are many ways and means for the anticancer effect of isoflavones.
Isoflavone Basic Information
- Chinese name: Isoflavone
- Chinese alias: Isoflavones; Soy isoflavones; Soy isoflavone series; 3-phenyl-4H-1-benzofuran-4-one
- English alias: Soy Isoflavone; SOY ISOFLAVONES; Soybean Isoflavones PE; Soybeanisoflavone; 3-phenyl-4H-chromen-4-one
- Molecular formula: C15H10O2
- Molecular weight: 222.2387
- Density: 1.239g / cm3
- Boiling point: 367 ° C at 760 mmHg
- Flash point: 171.1 ° C
- Vapor pressure: 1.41E-05mmHg at 25 ° C
- InChI = 1 / C15H10O2 / c16-15-12-8-4-5-9-14 (12) 17-10-13 (15) 11-6-2-1-3-7-11 / h1-10H [ 1]
Isoflavone structure
- It has always been considered to have vitamin P activity, and has been continuously found to have more physiological activities, and regulate the functional properties of the body's metabolism.
- Soy contains a variety of isoflavones. For comprehensive utilization, it can be extracted from soybean dregs and purified with petroleum ether. Among them, genistein has the health effects of lowering cholesterol, promoting calcium absorption, and regulating the body's immune function, so that soybean food has special edible value.
Isoflavone Product Features
- 1. Two-way regulation. Soy isoflavones are chemically related to estrogen activity as structural analogs, showing inhibition and synergy
- Soy isoflavones (2 photos)
- 2. It can selectively bind to estrogen receptors and has mild properties. It has strong affinity to these receptors such as brain, prostate, bladder, cardiovascular, and bone tissues, but has weak affinity to uterus, ovary, breast, etc. The activity is only 1 / 1000-1 / 100000 of estrogen. This avoids the risk that estrogen supplementation may induce cancer.
Isoflavone Product Features
Isoflavones prevent menopause syndrome
- Before and after menopause, due to the decline of ovarian function, the level of estrogen in the body decreases, causing the functional adjustment of various organs and tissues to be incompatible, and a series of diseases appear. Supplementing estrogen can achieve the purpose of preventing and treating such diseases.
- Menopausal women's performance: hot flashes, sweating, chills, chest tightness, palpitations, shortness of breath, dizziness, fluctuations in blood pressure, etc .; emotional instability, irritability, irritability or depression, worry, insomnia, memory loss, and lack of concentration 2. Comprehensive judgment has declined.
Isoflavones prevent and improve osteoporosis
- Osteoporosis refers to the reduction of bone tissue, resulting in brittle and brittle bones, and easy to fracture. Common in postmenopausal women and older men (due to hormonal changes or insufficient calcium and vitamin D). The incidence of osteoporosis in middle-aged and elderly women is much higher than that of men. The main reason is that estrogen levels decrease, bone metabolism appears negative balance, and bone mass decreases after ovarian function declines. Isoflavones can bind to estrogen receptors on bone cells, reduce bone loss, increase the body's absorption of calcium, and increase bone density.
Isoflavones prevent breast cancer
- Taking estrogen alone for a long time can increase the incidence of breast cancer and endometrial cancer by 5 to 7 times. Soy isoflavones have a similar structure to estrogen, so they can bind to female receptors on the cell surface and activate other anti-cancer mechanisms, reducing the risk of women suffering from endometrial cancer and breast cancer due to high estrogen levels.
Isoflavones prevent cancer
- Soy products contain 5 known anti-cancer factors, one of which is phytoestrogens (isoflavones), which are unique to soy foods. The scientists concluded that genistein's antioxidant and anti-proliferative properties are the main reasons for its anti-cancer effect. Soy isoflavones have obvious therapeutic effects on breast cancer, colon cancer, lung cancer, prostate cancer, skin cancer and leukemia. Soy isoflavones can also prevent the occurrence of ovarian cancer, colon cancer, gastric cancer and prostate cancer.
- A large number of studies have found that soy isoflavones can transform cancer cells into cells with normal functions. At the same time, they can also inhibit the structure of bad tumors and prevent tumors from growing and spreading.
Isoflavones prevent cardiovascular disease
- Heart disease is also an estrogen-related disease. Soy isoflavones, which are phytoestrogens, lower blood lipids and prevent heart disease. The mechanism of estrogen-like action is to promote thyroid hormone secretion and bile excretion. It is well proven that lowering low density lipoprotein (LDL) cholesterol without lowering high density lipoprotein (HDL) cholesterol when lowering cholesterol. Isoflavones are characteristic of flavonoids and have biological antioxidant effects, which is very important. Because low-density lipoprotein (LDL) cholesterol oxidation is a key factor in the process of arteriosclerosis. Women who receive 80 mg of pure genistein daily can increase arterial elasticity by about 26%.
Isoflavones prevent Alzheimer's disease
- Alzheimer's disease is currently the most common type of dementia, which is more common in women. Recent studies have shown that the human brain is also a target tissue for estrogen action. The hippocampal synaptic bodies with memory function in the brain contain estrogen receptors. The medical community has confirmed that estrogen levels are closely related to senile dementia. Soy isoflavones and true estrogen are good for the brain.
Isoflavone beauty and delay aging
- The estrogen-like effect of soy isoflavones can make women's skin smooth, delicate, soft, elastic and youthful. Women supplement estrogen to activate adipose tissue in the breast, so that free fat is directed to the breast, thereby achieving the effect of breast augmentation.
- Studies have shown that modern menopause occurs early, and long-term supplementation of soybean isoflavones can maintain normal levels of estrogen in the body, delay menopause, and delay aging.
Isoflavones improve menstrual discomfort
- Menstrual discomfort is generally related to the imbalance of estrogen secretion. Long-term supplementation of soybean isoflavones can maintain the normal level of estrogen in the body and achieve the purpose of improving menstrual discomfort.
Isoflavones improve sexual function
- The estrogen-like effect of soy isoflavones can increase the maturity of vaginal epithelial cells in women and increase the elasticity of vaginal muscles, thereby improving the quality of sexual life.
Isoflavones lower cholesterol
- Cardiovascular disease (CHD) is a multifactorial disease in which cholesterol (Ch) plays an important role. A large-scale study of 5,000 people in Japan showed that soy isoflavones have the effect of lowering cholesterol Ch and inhibiting thrombosis. A study of young women in the United Kingdom showed a dose-response relationship for isoflavones, with isoflavones above 45 mg per day reducing total Ch and LDL-Ch levels by 10% for 30 days, while 23 mg isoflavones had no effect.
Isoflavones prevent disease
- Soy isoflavones can reduce the body's susceptibility to serum LDL oxidation. After the serum LDL lipoprotein is oxidized, it activates the phagocytosis of macrophages in the human body, and develops into foam cells in the arterial wall, thereby forming atheromatous plaques. Soy isoflavones not only have their own antioxidant effects, but also induce an increase in the activity of antioxidant enzymes, increase the antioxidant activity of serum LDL, prevent the formation of atherosclerotic plaque in the arterial wall, and prevent atherosclerosis. At the same time increase the compliance of arterial blood vessels and dilate blood vessels. Soy isoflavones also inhibit the atherosclerotic process by affecting tyrosine kinases, including foam cells, fatty-like striations, hyperplasia, fibrous plaque infiltration, rupture and ulcers, keeping the heart arteries unblocked and preventing cardiovascular disease happened.
How to take isoflavones
- 1. As women's estrogen levels start to decrease after the age of 35, more than 400 estrogen-dependent tissues in the body will gradually age, resulting in irritability, sweating, hot flashes, insomnia, memory loss, cardiovascular dysfunction, etc. Problems followed, so exogenous estrogen was needed to supplement them. In this sense, soy isoflavones are generally needed by women after the age of 35 years.
- 2. Phytoestrogens are not drug estrogen, not only do not have any side effects, but also have a two-way regulation function. When the estrogen in the body is high, they can have anti-estrogen activity and have anti-breast cancer and endometrial cancer effects. When low, it plays the role of estrogen supplement and regulates human hormone levels. However, when using it, it should be used according to each person's physical condition and vitamins and trace elements. Therefore, it is best to consult a health doctor for a certain test and consultation before use.
- 3. Soy isoflavones currently on the market are of high purity and complex types. The former is suitable for women with severe estrogen deficiency and obvious recessive menopausal symptoms, and the latter contains vitamins and trace elements, so it is more suitable for maintenance and prevention. Purpose of women. However, it must be emphasized that teenage girls, pregnant women, and those with severe cardiovascular disease are banned.
Isoflavones are suitable for people
- 1. Women with loose and rough skin, increased wrinkles and dark spots.
- 2. Women with backache, leg pain, insomnia, and poor energy.
- 3. Women with bad temper, emotional instability, nervousness, and palpitations.
- 4. Women who suffer from physiological decline and menstrual discomfort.
Isoflavone References
- Soy isoflavones are multi-component soybean isoflavones extracted from the accumulation of genetically modified soybeans in Northeast Africa as raw materials. The three main components of soy isoflavones are genistein, daidzein and soybeans. Flavonoids are separated and enriched.
- Soy isoflavones are a mixture of polyphenols. So far, 12 compounds have been isolated from soybeans, that is, 9 kinds of isoflavone glucosides (glucoside) and 3 kinds of corresponding aglycones (aglucone) [3]. Natural isoflavones mainly exist in the form of glycosides, and as food and pharmaceutical raw materials, their physiological activities are mainly manifested by isoflavones in the form of aglycone. Moreover, the isoflavones extracted and isolated from plants are reliable in maintaining biological activity and using safety.
- 1 Introduction to Soy Isoflavones
- Soybean is the only food source of isoflavones, genistein and daidzein. It has been used as a food in southwestern Asia for 5,000 years, but only in the United States and western Europe since the twentieth century. The large consumption of soybeans by people in southwest Asia has reduced the incidence of certain cancers and cardiovascular diseases. Recent experimental data show that the active ingredient is phytochemica1s in soybeans, which can also prevent osteoporosis, nephritis and autoimmune diseases. disease.
- Isoflavones are mainly found in leguminous plants, among which the content of soybean is the highest, so it is particularly called soy isoflavones. It is distributed in soybean seed coats, hypocotyls and cotyledons.The concentration of isoflavones in the hypocotyl is 30 to 60 times that of the cotyledons, and its amount accounts for 30% to 50% of the total soybean isoflavone content. The site isoflavone content is shown in Table 1. In addition, the naturally occurring forms of isoflavones in soybean are mainly in the form of malonyl glycosides, with few acetyl glycosides and ligands. Malonyl glycosides are generally not stable and easily become glycosides during processing of soybeans. In addition, they will remove a CO2 and become acetyl glycosides when heated.
- Table 1 Isoflavone content of various parts of soybean
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- 2 Structure and properties of soybean isoflavones
- Soy isoflavones have the highest aglycone biological activity, accounting for 2 to 3% of total isoflavones in soybean, of which 97 to 98% are in the form of glucoside and conjugate, and malonyl glucosides About 55 ~ 65%. Malonyl and acetyl isoflavones can be hydrolyzed to form glucoside under heating and alkaline conditions. The glucoside can be hydrolyzed to remove the glucosyl group into the form of aglucone under the condition of strong acidic high temperature or the presence of enzyme.
- Soy isoflavones are a mixture of polyphenols. So far, 12 compounds have been isolated from soybeans, that is, 9 kinds of isoflavone glucosides (glucosides) and 3 kinds of corresponding aglycones (aglucone). Aglycones are free isoflavones. The three types of aglycones are daidzein (daidzein), genistein (genistein), and glycite (daidzein).