What Is Mild Cervical Dysplasia?

Uterine dysplasia, also known as immature uterus, was thought to be any period from the third trimester of pregnancy or from the birth of the fetus to puberty, due to internal or external factors causing the uterus to stop developing and different degrees of immature uterus. The cervix of a juvenile uterus is longer and more tapered, while the uterine body is smaller than normal, and it is often excessively forward or backward because of anterior or posterior wall hypoplasia. The ratio of the cervix to the uterine body is 1: 1 or 2 : 1, clinically often cause rare menstruation, primary or secondary amenorrhea, dysmenorrhea, infertility, abortion and so on.

Uterine dysplasia, also known as immature uterus, was thought to be any period from the third trimester of pregnancy or from the birth of the fetus to puberty, due to internal or external factors causing the uterus to stop developing and different degrees of immature uterus. The cervix of a juvenile uterus is longer and more tapered, while the uterine body is smaller than normal, and it is often excessively forward or backward because of anterior or posterior wall hypoplasia. The ratio of the cervix to the uterine body is 1: 1 or 2 : 1, clinically often cause rare menstruation, primary or secondary amenorrhea, dysmenorrhea, infertility, abortion and so on.

Chinese name

Uterine dysplasia

Foreign name

Uterine dysplasia

Uterine dysplasia I. Etiology and related diseases

Uterine dysplasia is mostly caused by hypothalamic-pituitary-ovarian gonad axis dysfunction, insufficient estrogen and progesterone secretion, uterine development restriction or stop growth, which can belong to the category of endocrine diseases. Immune cells also have receptors that accept neurotransmitters and endocrine hormones, and cytokines produced in the immune response also have regulatory effects on the nervous and endocrine systems. For example, IL2 slightly enhances FSH stimulation to produce progesterone and 20a-dihydrogen. The role of progesterone, interleukin 1 (IL1) can regulate the secretion of gonadotropins and sex steroids, regulate the level of sex hormones, affect the development and maturation of reproductive organs and germ cells, and thymus cells themselves can also produce growth hormone (GH), Luteinizing hormone-releasing hormone (LHRH), prolactin (PRL) and other hormones and neuropeptides. Thymosin produced by the thymus also regulates the nervous and endocrine systems.

Uterine dysplasia 2. Differential diagnosis

Clinical symptoms: thin menstruation, low menstrual flow, infertility, and varying degrees of mammary dysplasia. [3] Rectal-abdominal diagnosis can involve a small, active uterus.

1. Medical history Such patients have a factor of abnormal cervical body ratio, small external opening of the cervix, extreme forward or backward flexion of the uterine body, often dysmenorrhea, less menstruation, amenorrhea, infertility and other medical history.

2. Gynecological examination of the uterus is smaller than normal, the cervix is slender, the neck opening is small, and the body-to-neck ratio is 1: 1 or 1: 2.

3. B ultrasound can measure the length, width and thickness of the uterus. Further diagnosis.

4. Determination of sex hormones. Radioimmunoassay or enzyme-labeled method was used to determine FSH, LH, E2, P and T values.

Uterine dysplasia III. Principles of treatment

Estrogen receptor (ER) and progesterone receptor (PR) exist on the surface of hormone target cells and can specifically bind to the corresponding hormones to produce specific physiological or pathological effects. ER and PR are mainly distributed in the uterus, cervix, For target organs such as the vagina and breast, estrogen can stimulate the synthesis of ER and PR, while progesterone can inhibit the synthesis of ER and indirectly inhibit the synthesis of PR. ER is a class of transcription factors activated by ligands and is a member of the nuclear acceptor superfamily. In the uterus, estradiol and ER are factors that promote proliferation. After ER and estrogen are combined in the target organ, they produce corresponding physiological effects and can stimulate uterine growth.

Estrogen directly acts on target organs and uterine dilatation for the treatment of uterine dysplasia with small side effects, fast effect, significant curative effect, economy and safety.