What Is Perivascular Dermatitis?

Vascular dermatosis refers to a class of inflammatory diseases that originate in the skin vessel wall. The common histopathological manifestations are swelling of vascular endothelial cells, fibrin-like degeneration of vascular walls, and infiltration or granuloma of inflammatory cells around the tube. form.

Vascular skin disease

Vascular dermatosis refers to a class of inflammatory diseases that originate in the skin vessel wall. The common histopathological manifestations are swelling of vascular endothelial cells, fibrin-like degeneration of vascular walls, and infiltration or granuloma of inflammatory cells around the tube. form.

The causes of skin vasculitis can be summarized as: idiopathic: 45% to 55%, most of which are unknown; infectious: 15% to 20%, which can be caused by bacterial, viral, parasitic and fungal infections; inflammation Sexual diseases: 15% to 20%, patients with systemic lupus erythematosus, rheumatoid arthritis, Sjogren's syndrome, Behcet's disease, inflammatory bowel disease, etc .; drugs: 10% to 15%, often caused by It is caused by antibiotics, oral contraceptives, anticonvulsants, phenothiazine antipsychotics, antithyroid drugs, retinoic acid drugs, etc. Recently, increased application of influenza vaccines, interferon and cytokine antagonists can also induce this Disease; tumor: 5%, mainly tumors originating from the bone marrow or lymphatic system. The pathogenesis of this disease is not fully understood and may be related to allergies (mainly type III and type IV allergies).

The clinical manifestations are related to the size, scope, and inflammatory response of the affected blood vessels. For example, capillaries and microvasculitis are mainly manifested as purpura, edema, erythematous erythema, necrotizing pimples, blister, blood blister, and small nodules. Moderate or larger Vasculitis manifests as nodules, necrosis and ulcers; vasculitis can be confined to the skin and can also affect other systems (such as joints, kidneys, lungs, gastrointestinal and nervous systems, etc.); it can be accompanied by systemic symptoms such as fever and fatigue .

Classification criteria for vasculitis vary. At present, it is generally classified according to the type of cell infiltration, the size of affected blood vessels, and the presence or absence of granulomas: Leukocytic macroangiitis: such as nodular polyarteritis; Leukocytic small arteritis: such as allergic skin blood vessels Inflammation, Behcet's disease, allergic purpura, allergic skin-systemic vasculitis, serum disease, urticaria vasculitis, etc .; lymphocytic vasculitis: such as acute acne-like lichen psoriasis, skin disease Nodular vasculitis; granulomatous macroangiitis: such as Wegener's granulomatosis, allergic granulomatosis, etc .; granulomatous small vasculitis: such as lymphoma-like granulomatosis, facial granulomatosis, etc.