What Is Respiratory Burst?

Respiratory bursts, also called oxygen bursts, are one of the important ways of free radical generation during reperfusion.

Respiratory burst

Reperfused tissue regains oxygen supply within a short period of time

In innate immunity, after pathogenic microorganisms are engulfed, an oxygen-dependent killing mechanism of immune cells.

NADPH oxidase: NADPH + 2O2 generates NADP + 2O-2 + H +

2O-2 + 2H + generates H2O2 + O-2

H2 O2 + Cl- to OCl- + H2O to 'O2 + Cl- + H2O to H2O2 +' O2

Both Cl- and OCl- are toxic and can kill pathogens that swallow the cells.

After killing, to reduce peroxide, a peroxisome is needed.

It is reduced to H2O + O2 by the action of superoxide dismutase.