How Do I Choose the Best Ichthyosis Treatment?

Ichthyosis is commonly known as (snake ringworm), 70% is hereditary (genetic disease). It is more common than children. It occurs on the back of the torso of the extremities. The skin is dry and rough. Particles are blocked, and no sweaty hair is grown. In severe cases, the skin is gray-brown scales and deep markings, which spread to the whole body with age. The disease is characterized by heavy winter and light summer.

Congenital ichthyosis

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Ichthyosis is commonly known as (snake ringworm), 70% is hereditary (genetic disease). It is more common than children. It occurs on the back of the torso of the extremities. The skin is dry and rough. Particles are blocked, and no sweaty hair is grown. In severe cases, the skin is gray-brown scales and deep markings, which spread to the whole body with age. The disease is characterized by heavy winter and light summer.

Chinese name

Congenital ichthyosis

Commonly known

Ringworm

more than

Childhood

Prone areas

Limbs torso

Ichthyosis is a common hereditary skin keratosis dermatosis, known by traditional Chinese medicine as snake ringworm. Divided according to different genetic methods:

1. Autosomal dominant inheritance of ichthyosis vulgaris:

Common. Onset usually begins several months after birth. The condition worsens with age, and the symptoms are severe in winter and mild in summer.

Basic features: dry skin, yellowish-brown or dirty brown scales with rhombus or polygonal shape, edges raised, and the center close to the skin, fine or bran-like.

The rash mainly occurs on the extremities of the extremities, followed by the back. The head may have mild scales. In severe cases, it may affect the whole body, but the axillary and hip folds are often not affected. The back of the hand may have keratotic lesions of the hair follicles.

In most patients, the secretion of sebaceous glands and sweat glands of the whole body skin is reduced, resulting in dry and less sweaty skin, so patients feel uncomfortable.

2. Sex-linked hereditary ichthyosis vulgaris

1) Rare. Recessive heredity occurs only in men (women are carriers) and develops shortly after birth.

2) The rash is widely distributed, and the flexion and wrinkles can also be affected. The abdomen is heavier than the back. The rash is large and obvious, and it can spread to the cubital, axillary, and popliteal fossa.

3) For slittoscopy, both men and women can see that there are many small turbid spots on the posterior corneal wall or on the elastic membrane.

3. Epidermolytic keratosis ichthyosis (congenital ichthyosis-like erythroderma) is an autosomal dominant genetic disease, and was previously called bullous ichthyosis-like erythroderma. At the time of the disease, the skin is thickened like horny, and armor-like scales cover the entire body. After birth, the desquamation left a rough wet surface with loose bullae. Scales were formed thereon again. The flexion of the extremities and folds of the groin, wrist, axillary and elbow have thick gray or verrucous scales with local wart-like damage, so it is also called porcupine ichthyosis.

4. Lamellar ichthyosis (congenital ichthyosis-like erythroderma) is an autosomal recessive inheritance. In the past, it was called scaly-like erythroderosis without bullae, which can be divided into light and heavy type.

1) The heavy ones are ugly. Most are stillbirths or die after delivery.

2) Light cases are known as lamellar ichthyosis, which develops after birth. The outer cuticles are thinner, such as collodion-like cuticles, and the skin is red with desquamation.

5.Limited linear ichthyosis

Autosomal recessive inheritance, a variation of lamellar ichthyosis.

Long-term treatment of ichthyosis has brought both economic and spiritual burdens to patients, seriously affected the appearance and physical and mental health of patients, and even inherited the next generation, which has plagued humans for many years.

Clinical studies have found that the onset of ichthyosis is due to genetic causes that cause heat and blood toxicity in the body to form a certain substance metabolism disorder. This metabolic relic is not easy to be excreted from the kidney, but has a strong affinity with the skin. Because of this metabolic relic Melting point and dissolution are greatly affected by temperature and humidity. In summer, the skin has sufficient moisture and high temperature. This substance is in a liquefied and dissolved state, so the damage to the skin is relatively light. However, as soon as autumn enters, the temperature decreases and the climate is dry. Once the substance is secreted to the surface layer of the skin, it quickly solidifies, and the skin moisture is reduced, and the substance cannot be effectively dissolved. Therefore, it condenses and deposits in the stratum corneum of the skin. The symptoms of Xia Qing, on the one hand, cause damage to the skin, which greatly accelerates the rate of keratinization of the skin and produces a large number of scales; on the other hand, it blocks the hair follicles and sweat ducts, causing sebaceous glands and sweat glands to secrete disorders, and eventually causes the skin to lose moisture and change. It was extremely dry. Due to the difference in the distribution of sebaceous glands and sweat glands throughout the body and the difference in the quality of each body, the amount of metabolic relics secreted from sebaceous glands and sweat glands is different. Therefore, the clinical symptoms of patients with different types of ichthyosis are different.

Ichthyosis is a genetic disease that is rooted in genetic abnormalities. Different types of ichthyosis have different chromosomes and localizations. The location of pathogenic genes is still under study. But how genetic abnormalities cause disease, autosomal dominant dominant ichthyosis vulgaris, why sex-linked hereditary ichthyosis vulgaris are normal at birth, and symptoms do not appear until a certain age, these are still unknown.

Is "ichthyosis" related to neuropsychological factors?

The answer is yes. Spirit plays a vital role in a person's health? Have you ever heard the allusion "Cup Bow Snake Shadow", this story fully illustrates the spirit. The effects of neurological factors on a person's emotional health. Of the tens of thousands of cases we diagnose and treat, 35% are caused by mental causes. Some are overstimulated, some are overstretched, and others are overly depressed.

Ichthyosis is a genetic disease that is rooted in genetic abnormalities in chromosomes and is a genetic disease. So ichthyosis can be inherited but not contagious.

Among the types of ichthyosis, the most common are autosomal dominant hereditary ichthyosis and sex-linked hereditary ichthyosis. They inherit it completely differently.

The inheritance of autosomal dominant ichthyosis vulgaris is dominant.

As the name suggests, "autosomal dominant inheritance of ichthyosis vulgaris" can be judged from the disease name, and its genetic mode is dominant inheritance. But from time to time, some patients ask: My parents do not have fish disease, and I have inherited ichthyosis, or my parents have a previous generation, and my parents are normal, and they are sick again. Is this recessive inheritance? In fact, it is completely wrong to understand the dominant or recessive inheritance in this way.

Except for human red blood cells, each cell has a nucleus. The main component of the nucleus is the chromosome, which is the basic unit of inheritance. There are 46 chromosomes in each cell nucleus, 23 from each of the father and mother. They are combined in pairs to form 23 pairs, of which 22 are autosomes and the other is the sex chromosome. Because chromosomes are the basic unit of inheritance, defects in any pair of chromosomes can cause hereditary diseases. Among the 23 pairs of chromosomes that are paired with each other, if one of the pair of chromosomes is abnormally stained, the disease is dominantly inherited; while a single abnormality does not show symptoms, but it is abnormal at the allelic sites of both It is then recessive that shows symptoms. Because the probability of a single chromosome abnormality is much higher than the probability of a pair of chromosomal abnormalities at the same time, the incidence of dominant genetic disease is much higher than recessive genetic disease. In patients with autosomal dominant inheritance of ichthyosis vulgaris, the root cause is an abnormality in one of 22 pairs of autosomes. At present, the specific gene abnormality of that chromosome is unclear, so prenatal diagnosis of autosomal dominant inherited ichthyosis vulgaris cannot be performed. It is believed that with the study of the genetic level, it will soon be clear that the prenatal diagnosis of the disease can be carried out at that time.

The inheritance of autosomal dominant ichthyosis vulgaris has the following characteristics:

1. Because the pathogenic gene is located on the autosome, the inheritance has nothing to do with gender, which means that both men and women can develop the disease and the opportunity is equal;

2. One of the patient's parents must be a patient, but the vast majority are heterozygous (that is, only one of the paired chromosomes is abnormal), and about 1/2 of the patients' siblings are also likely to be patients;

3, continuous transmission of the disease can be seen in the family genealogy, that is, patients can usually be seen for several consecutive generations. Of course, due to the one-child policy in China, this situation may not be typical now.

4. When the parents are not sick, the children are generally not sick.

So maybe some patients will ask, then my parents are fine, why do I get sick? There may be two reasons for this. One is that the parent may have a genetic abnormality, but the symptoms are not noticed, or The symptoms themselves are almost invisible with age, and the patient may not know the condition of the parents. The second is that there is no genetic abnormality in the parents, but the gene mutation occurs during the embryonic development and development of the disease. From time to time, there are ichthyosis patients in the forum. It is quite pessimistic to think that it is better to find a fish to get married in this life. Because if both spouses are patients (considering that they are all heterozygous), then the child's probability of illness will reach 3/4.

Recessive inheritance of sex-linked hereditary ichthyosis vulgaris.

In addition to red blood cells, humans have 46 chromosomes in each nucleus, 23 from each of the father and mother. They are combined in pairs to form 23 pairs, of which 22 are autosomes and the other is the sex chromosome. Among them, XY is male and XX is female. The root cause of sex-linked hereditary ichthyosis vulgaris is the genetic abnormality on the X chromosome in this pair of sex chromosomes. Men have only one X chromosome, and as long as there is an abnormality in the X chromosome, they can show symptoms of ichthyosis; women have two X chromosomes, but only one X chromosome gene abnormality does not show symptoms, only when both chromosomes are abnormal Only when symptoms appear. Therefore, sex-linked ichthyosis is X-linked recessive. Because the probability of both women's chromosomes being abnormal is relatively small, and men's disease will occur as long as the gene on the X chromosome is abnormal, so sex-linked hereditary ichthyosis is more common in men and rare in women.

1. The most common among genetic families of sexually-linked ichthyosis is that female carriers of normal genes are matched with normal males. Half of the offspring will be affected and half of the daughters will be carriers of genetic abnormalities.

2. Male patients are mated with normal women. All sons and daughters are normal, but the father's X abnormal gene must be given to the daughter, so all daughters are carriers of genetic abnormalities.

The genetics of sex-linked inheritance ichthyosis vulgaris has the following characteristics:

1. There are far more male patients than female patients in the crowd, and there are often only male patients in the family;

2. The parents are not sick, the son may get sick, but the daughter will not get sick; if the son gets sick, the mother must be one of the carriers, and the daughter has a 1/2 probability of being a carrier;

3. Brothers, grandfathers, uncles, cousins, nephews, etc. of male patients may also be patients;

4. If a woman is a patient, her father must be a patient, and her mother must be a carrier.

According to the characteristics of genetics, if men are patients with sex-linked ichthyosis, it is best to choose to have a boy, so that the inheritance of the offspring can be cut off, and future children will not suffer the inheritance. If there is a patient with sexually-linked ichthyosis in the family of the woman, it is recommended to go to the relevant medical department for prenatal consultation and testing during pregnancy. It is found that if it is a girl's gene carrier or a male's gene abnormality, the pregnancy can be terminated. There is only one pair of sex chromosomes, and more studies have been done so far. The genetic abnormalities of sex-linked ichthyosis have also been basically identified. Now, medical departments have carried out prenatal testing research.

1. Ichthyosis vulgaris: It is mainly manifested in dry brown rhombuses on the extremities of the extremities and trunk, or polyangular scales. There are often obvious follicular keratosis papules on the upper arms and thighs, and the palms and toes are affected. The incidence is very high. Its keratinizing scales are caused by several layers of keratinocytes that do not fall off and accumulate. They appear more than a few months after birth. They are most severe at about 5 years old. Symptoms may be reduced after puberty, but the disease worsens with age and improper treatment. .

2. Sexually linked hidden ichthyosis: can occur after birth or in infants. The skin scales are large and noticeable. They are yellow-brown or stained black with large fish scales. The skin is dry and rough and often spreads throughout the body. The axillary and elbow sockets can also be affected; the abdomen and back are especially heavy. If the face is affected, it is limited to the front of the ear and the side of the face. Keratosis of the hair follicles generally does not occur. The skin on the toes is normal, and the skin lesions do not decrease with age, but sometimes they gain weight.

3. Epidermolytic hyperkeratosis ichthyosis, also known as bullous congenital ichthyosis-like erythroderma: an autosomal dominant genetic disease with a high rate of distortion. Clinically rare. After birth or months after birth, there may be general and localized damage. Generalized people have armor-like thick scales at birth, and they fall off after birth, and there are widespread flushes and scales. Stripped scales show a smooth surface, erythema can gradually disappear, and thicker wart scales can occur. In those who are limited, thick scaly cuticles can be found only on the flexion of the limbs and the wrinkle wall.

4. Lamellar ichthyosis. It is an autosomal recessive inheritance. After birth, the whole body is tightly wrapped by a wide layer of human cotton-like film, which often causes eyelids and lip eversion. After a few days, the film fell off, and the skin showed extensive diffuse flushing, with off-white or gray-brown polygonal or diamond-shaped large scales, fixed in the center, and free of edges. It often occurs symmetrically throughout the body, with limbs flexed, and the elbow, axillary, and vulvar areas are more obvious. Excessive keratinization of the toes, overgrowth of nails and hair, after a slow course of disease, can survive forever, and can reduce erythroderma into adulthood, but scales still exist.

Ichthyosis-related syndromes are mostly autosomal recessive. In addition to involving multiple organs and / or tissues, accompanied by varying degrees of ichthyosis-like damage, they are also an important part of these syndromes. IAS with different clinical symptoms may be a manifestation of gene pleiotropy. The ichthyosis-related syndromes are:

Ichthyosis spastic paralysis mental retardation syndrome

It is a rare syndrome consisting of congenital ichthyosis, spastic limb paralysis, and triad of mental retardation. Almost all patients have extensive ichthyosis damage at birth, and about half have varying degrees of erythroderma. Red skin disease gradually eases with age, and disappears as adults. There are three types of ichthyosis in life: the wrinkles are often translucent black or black-yellow keratinization damage, the skin texture is significantly deeper; lamellar ichthyosis damage on the limbs and lower abdomen; other damage Appears as a large number of thin dry scales. The same patient often has three types of lesions at the same time. Eyelid eversion is common. Individual patients have dry, slender, and dull hair.

Most patients develop neurological disease within 4 to 30 months after birth, mainly due to mental retardation, spastic quadriplegia or paraplegia. Spastic paralysis of both lower extremities progresses progressively, at least until puberty resolves or ceases to progress. Most patients have similar lesions in the upper limbs, but milder. The vast majority of patients have mental retardation and do not increase with age.

Ichthyosis dwarf mental retardation syndrome:

It is a syndrome of ichthyosis-like erythroderma, dwarfism, mental retardation, and spastic paralysis. In the medical record: 3 patients were found among 5 children of a close relative, a married couple. The proband was an 18-year-old female, 137cm tall. At the time of birth, he had erythroderma on his face and a few bullae on both feet. Months after birth, diffuse redness throughout the body, skin atrophy and thinning like parchment. After 16 years of age, he found spastic paralysis of the lower limbs, which made walking difficult. IQ 38. The 12-year-old and 8-year-old sisters and brothers had similar skin lesions, mental retardation, and dwarf shape except for spastic paralysis.

Illness epilepsy ichthyosis syndrome:

Onset in infancy. It is mainly composed of a triad of mild ichthyosis-like erythroderma, mental retardation, and epilepsy. However, some patients also have symptoms such as genital hypoplasia and dwarfism. Poor intelligence, unable to take care of themselves. Epilepsy is mostly a large seizure. The disease may be caused by autosomal recessive inheritance, but sex-linked inheritance cannot be ruled out.

Ichthyosis Hepatosplenomegaly Ataxia Syndrome:

Dykes and Harper (1979-1980) first reported the disease. The proband was a 69-year-old male. Children have systemic xeroderma. Progressive aggravated dysarthria and gait instability occurred after age 62. Xeroderma is most pronounced with limb extension and deep palm prints. Hepatosplenomegaly was enlarged and hard but liver function was normal. Neurological examination shows signs of senile dementia. Ataxia of limb and trunk movements, dysarthria, and difficulty staring up with both eyes.

Hair shaft abnormal intelligence disorder ichthyosis syndrome:

The disease is similar to ichthyosis-like erythroderma, brittleness caused by abnormal hair dryness, mental retardation, reduced fertility, and short stature. In order to find that the parents of this kind of patients do not have the same disease, and both men and women have the same disease, it is believed that the disease is caused by autosomal recessive inheritance.

Ichthyosis polyneuritis ataxia syndrome:

As a rare autosomal recessive disease, the main symptoms and signs of the patient are due to the involvement of the nervous system. Onset in infancy. Ataxia is characterized by gait instability, intentional tremor, and nystagmus, and weak limbs, weak distal muscles, and even muscle atrophy. Deep launch weakens or disappears. In addition, there may be neurological deafness and loss of smell. Most patients have mild ichthyosis lesions. Patients often die from acute polyneuropathy, renal failure, or heart failure.

Ichthyosis bamboo-like genetic allergy syndrome:

The disease mainly consists of a triple combination of congenital ichthyosis-like erythroderma, bamboo-like hair, and genetic allergic qualities, which is rare. Patients are mostly women with diffuse erythroderma and desquamation at birth or shortly after birth. But the degree, range and duration of redskins vary. The clinical manifestations of ichthyosis are no different from those of localized linear ichthyosis. The hair is thin, soft, dull, and abnormally dry. It is presented as an overlying brittle hair, which is called bamboo hair like bamboo.

1. The purpose of treatment is to relieve symptoms, increase water content in the stratum corneum and promote normal keratosis;

2. For systemic treatment, try vitamin A, 13-cis-retinoic acid, pomegranate or methotrexate;

3. It can be used locally to increase the moisture content of the stratum corneum and remove substances that are over-keratinized, such as Linkang;

4, topical antibiotic ointment for infection.

5.Traditional Chinese medicine treatment mainly focuses on removing dandruff, regenerating skin, improving skin microcirculation system, strengthening skin metabolism, and regulating human autoimmune function.

1. Hereditary diseases;

2. Type 4 skin lesions;

3. Histopathological changes

(1) Dominant hereditary ichthyosis: moderate hyperkeratosis of the epidermis with thinning or disappearance of the granular layer;

(2) Sexual ichthyosis vulgaris: hyperkeratosis, normal or slightly thick granular layer;

(3) Epidermal lysis and hyperkeratosis Ichthyosis: Excessive keratinization, epidermal cells loosen, and granules degenerate.

Can ichthyosis patients get married and have children?

Ichthyosis is a genetic disease with its roots in genes. At present, it is impossible to cure or change the inherited genes through treatment. Therefore, whether treatment has no effect on hereditary probability. Ichthyosis does not endanger health and has no effect on the patient's survival and longevity, but only on appearance and psychology. Medically, ichthyosis patients are not unsuitable for marriage. Patients can get married or have children. Different types of ichthyosis have different ways and genetic probabilities. It should be noted that if the two patients with ichthyosis are married, the genetic probability of the child will increase significantly. For patients with sex-linked ichthyosis, if the male is a patient, you can choose to have a boy, so that the boy will not develop the disease and no longer carry the genetic gene; if the woman is a sex-linked gene carrier, then you can choose to have a girl In this way, girls will not get sick, but there is still a half probability that they are carriers of sexually-linked ichthyosis. If they are born boys, then they are half likely to be sick.

At present, relevant medical institutions have carried out research and testing on the prenatal testing of sex-linked ichthyosis, and can consult the relevant medical departments. If it is an autosomal dominant hereditary ichthyosis vulgaris, then it can only be left to chance. The incidence of boys and girls is the same, with a 50% probability. Therefore, it is necessary to consider whether the child has to decide according to the actual situation. Because the genetic location of autosomal dominant inherited ichthyosis vulgaris is unclear, prenatal genetic testing is not yet possible.

Ichthyosis is a keratotic skin disease that usually has a genetic family history. Clinical manifestations Dry and rough skin on the trunk of the extremities of the extremities, accompanied by pale brown to dark brown fish scales and deep markings, reduced sweat gland secretion, mild winter and summer, and severe skin cracking and stiffness. If left untreated or improperly treated, it can affect whole-body genetic offspring.

First of all, you must feel comfortable, avoid depression, and have the confidence to overcome the disease and adhere to treatment.

Cold, greasy foods such as fish, seafood, and chili should not be eaten in the diet. Eat more fruits and vegetables containing vitamins C, A, and E, such as apples, bananas, tomatoes, and radishes. Eat more nourishing liver and kidney foods. Avoid drinking all kinds of alcohol (including liquor, beer, wine).

General foods that need attention include spicy foods such as wine, garlic, shallots, chives, peppers, etc .; animal proteins such as fish, shrimp, lamb, chicken, beef, etc .; others such as coriander, toon, celery, mushrooms, etc.

Ichthyosis is equivalent to "snake ringworm" in Chinese medicine. For example, in Sui's "Essence of Diseases and Snakeskins", "Snake skins are treated by the wind and the evil spirits. They are closed by the wind, so the blood is turbid, and the skin cannot be glorious. Peel, even like snake scales. " Now it is thought that most of them are caused by insufficient congenital endowment, which cause blood deficiency, wind and dryness, or blood stasis block, and the body skin loses nutrition. Insufficient endowment, less kidney essence failure, skin loss due to essential blood support and skin malformation, essential blood cannot be moisturized, dryness and wind, or external wind; caused by blood stasis, due to endowment Weakness, qi and blood stasis, poor meridians, and body skin insufficiency.

Chinese medicine treatment should be Yiqi Sanyu, Rongji emollient, clearing heat and detoxifying.

Ichthyosis is a hereditary keratosis dermatosis. Its common feature is that there are many dry, rough-like scaly scales on the extremities or trunk of the limbs, keratinized scales, deep markings, and white skin. Cold and dry seasons worsen, and warm and humid seasons ease. It is easy to cure and easy to recur. Although ichthyosis has no direct harm to human health, it has some discomfort compared with normal people, which particularly affects the beauty of the human body. In severe cases, skin cracks, bleeding and other symptoms may occur, causing extreme Big pain. With the progress of the times and the continuous improvement of living standards, people are desperate for the treatment and rehabilitation of ichthyosis. How to overcome ichthyosis is a new topic in the medical field.

Can ichthyosis be completely cured?

Generally believed to be related to neuropsychological factors, endocrine disorders, immunological abnormalities, and digestive disorders, etc. The etiology of ichthyosis can be summarized into several major factors: genetic, neuropsychological, chemical, endocrine, infectious or external factors, etc. The pathogenesis of this disease is multi-faceted, but no factors and any part can be related to microcirculation disorders. We are working hard to improve the microcirculation when researching therapeutic drugs. The effects of neurological factors on a person's emotional health. Among the tens of thousands of cases diagnosed and treated, 35% were caused by mental reasons. Some were over-stimulated, some were over-stressed, and others were overly depressed.

Ichthyosis vulgaris is characterized by thinning of the epidermis, mild and moderate thickening of the stratum corneum, reduction or lack of granular layers, hair follicles and sweat glands may have keratinous embolism, and the number of sebaceous glands is reduced. Thickening, prominent nail processes, infiltration of lymphocytes evenly distributed around blood vessels, slightly reduced number of sweat glands; bullous congenital ichthyosis-like erythroderma manifested as hyperkeratosis and spinous layer hypertrophy, and the granular layer contains coarse particles There are reticular vacuoles in the granular layer and the upper part of the spinous layer, vesicles can be seen in the epidermis, and inflammatory cells infiltrate in the superficial layer of the dermis; lamellar ichthyosis is characterized by moderate hyperkeratosis, and some are focal keratosis, granules The layer is thinner or slightly thicker, the spinous layer is moderately hypertrophic, and the upper layer of the dermis is infiltrated with inflammatory cells; non-bulous congenital ichthyosis-like erythroderma is manifested as hyperkeratosis, accompanied by mild hypokeratosis and spinous layer hypertrophy , Superficial dermal lymphocyte infiltration. Director Lu Shichao of the Department of Dermatology of the 306 Hospital of the Chinese People's Liberation Army introduced Dr. Lu to introduce that it may be possible to try to use some topical retinoids to improve the scale of fish scales before summer. This can eliminate the trouble of wearing shorts and short skirts, and it is simple and easy to use. However, more severe patients need to take oral medication under the guidance of a doctor.

The latest research shows that the disease is in the epidermis, its roots are in the viscera and blood, and the occurrence of ichthyosis is due to genetic factors that cause metabolic disorders in the body. This metabolic relic is not easy to be excreted from the kidney, but has a strong affinity with the skin. When it accumulates in the body to a certain degree, it is gradually secreted to the outside through the sebaceous glands and sweat glands, thereby achieving the purpose of excretion and clearance. Because the melting point and dissolution of this metabolic relic are greatly affected by air temperature and humidity, the skin has sufficient moisture and high temperature in summer, and this substance is in a liquefied and dissolved state, so the damage to the skin is relatively light. However, as soon as autumn enters, the temperature decreases and the climate is dry. Once the substance is secreted to the skin surface, it rapidly solidifies, and the skin moisture is reduced, which cannot effectively dissolve the substance, so it coagulates and deposits in the stratum corneum of the skin. As a result, on the one hand, the skin is damaged, and the keratinization of the skin is greatly accelerated, and a large number of scales are generated; on the other hand, the hair follicles and sweat ducts are blocked, causing sebaceous glands and sweat glands to be secreted, and eventually shrinking occurs, and the skin loses moisture and becomes abnormal. dry. Due to the differences in the distribution of sebaceous glands and sweat glands throughout the body and the individual's physical fitness, the amount of metabolic remnants secreted from sebaceous glands and sweat glands are different, so they show skin lesions in specific parts, different types of ichthyosis, and different severity. Mild patients only have dry, rough, desquamated, less shaved hair, heavier winters, lighter or completely good skin in the extremities, abdomen, and buttocks; moderate patients have obvious white fish scales; severe patients are also accompanied by Brown or taupe fish pattern; more severe fish scales.

By combining the drug with the metabolic residues in the body, it is excreted from the kidneys, thereby reducing the amount of secretion from the skin, reducing it until the damage to the skin is eliminated, and the skin gradually returns to normal by its own repair function. Since the accumulation of the metabolic residues in the body is large at the beginning of treatment, it needs to be removed first. Due to individual differences, the length of the process of removing the remnants must be different, so how long the effect will vary from person to person, but based on the pathogenesis, it should be more obvious in about ten days of medication. Full recovery after taking 2 to 3 courses!