How Effective Is Doxycycline for Syphilis?

Doxycycline tablets are a drug whose main effect is used for tetanus, gas gangrene, yas, syphilis, gonorrhea and leptospirosis, as well as Actinomyces and Listeria infections in patients with penicillin allergies.

Doxycycline tablets

Doxycycline tablets are a drug whose main effect is used for tetanus, gas gangrene, yas, syphilis, gonorrhea and leptospirosis, as well as Actinomyces and Listeria infections in patients with penicillin allergies.

Drug Name

Doxycycline tablets

Foreign name

DOXYCYCLINE HYCLATE TABLETS

Dosage form

This product is light yellow tablet

Drug type

common name:

This product is completely absorbed orally, and can absorb more than 90% of the dosage. The effect of eating on the absorption of this product is small. After a single dose of 100mg of this product, the blood drug

1. This product can be used in the following diseases as one of the selected drugs: (1)

For adults, the first day is 100 mg, once every 12 hours, followed by 100 to 200 mg, once a day, or 50 to 100 mg, once every 12 hours. Neisseria gonorrhoea urethritis and cervicitis: 100 mg once every 12 hours. A total of 7 days. Non-gonococcal Neisseria urethritis, caused by Chlamydia trachomatis or Ureaplasma urealyticum, and simple urethritis, cervicitis, or rectal infection caused by Chlamydia trachomatis: 100mg once a day, twice a day, at least for a course of treatment 7th. Syphilis: 150mg once every 12 hours for at least 10 days. For children over 8 years old, the first day is 2.2 mg / kg, once every 12 hours, followed by 2.2 to 4.4 mg / kg, once a day, or 2.2 mg / kg, once every 12 hours. The dosage for children over 45kg is the same as that for adults.

Take 10 tablets of this product, accurately weigh, grind fine, accurately weigh an appropriate amount (approximately 40mg of doxycycline), shake well, filter, and accurately take 5ml of the filtrate, place it in a 50ml measuring bottle, add 0.01 The mol / L hydrochloric acid solution was dissolved and diluted to the mark. 20 l of the solution was injected into a liquid chromatograph and measured according to the method of doxycycline hydrochloride.

1. Digestive system: This product can cause nausea, vomiting, abdominal pain, diarrhea and other gastrointestinal reactions. Occasionally, esophagitis and esophageal ulcers have been reported in patients who are bedridden immediately after taking the drug.

2. Hepatotoxicity: It is prone to occur in patients with fatty liver degeneration and pregnant women. It can also occur in patients who do not have the above conditions. Occasionally pancreatitis can occur, and pancreatitis caused by this product can also occur simultaneously with liver toxicity, and the patient is not accompanied by primary liver disease.

3 Allergic reactions: mostly maculopapular and erythema, a few patients may have urticaria,

Contraindications: Patients with a history of tetracycline allergy are contraindicated

1. Excessive reproduction of resistant bacteria may occur when using this product. Once a secondary infection occurs, discontinue this product and treat it accordingly.

2. In the treatment of sexually transmitted diseases, if it is suspected to be accompanied by Treponema pallidum infection, it must be done before medication

Disabled for children under 8 years

Whether the medication affects conception depends on the metabolism and half-life of the drug.

The half-life of doxycycline is 12 hours, and the concentration of the drug in human blood has been metabolized by 50% after 12 hours after taking the drug. Then, the drug can be metabolized from the body within 1-2 days without accumulation. .

Azithromycin has a blood half-life of 72 hours, and the drug can be fully metabolized in about a week.

Vitamins and glucose have no effect on conception.

Based on the above pharmacokinetics, if you stop taking medicine during the May Day period, there are no concerns about affecting pregnancy until now. According to the doctor's health, you can choose to be pregnant at the right time. The next month is possible

Use with caution in elderly patients

1. This product can inhibit the activity of plasma prothrombin, so patients receiving anticoagulant therapy need to adjust the dose of anticoagulant.

2. When barbiturates, phenytoin, or carbamazepine are co-administered with this product, the above drugs can reduce the doxycycline blood concentration due to the induction of microsomal enzyme activity, so the dose of doxycycline must be adjusted.

This product has no specific antagonists. When the drug is overdose, symptomatic treatment and supportive treatment such as vomiting, gastric lavage and plenty of water and fluid replacement should be given.

Shading, sealed

Specification 0.1g * 12 tablets / box quantity Doxycycline hydrochloride tablets (doxycycline tablets) / Guangdong South China Medicine Set / 50mg * 100s / bottle / 6 yuan