Is it safe to combine naproxen and aspirin?

naproxen and aspirin are widely available medicines that are used to control mild to medium pain. Individuals sometimes combine these drugs in an effort to get more pain relief. Mixing these drugs may not occasionally be harmful, but there are clear interactions between the two, which can create a university or high -frequency combination definitely dangerous.

Both of these drugs have a clear, albeit overlapping ways of affecting the human body, which contributes to their safety level in combination. Naproxen and aspirin inhibit the enzyme cyclooxygenase-2 (COX-1) involved in the inflammatory reaction of the immune system. In this way they reduce pain and swelling. They also inhibit the type of Cox's enzyme in the stomach, Cox-1 involved in the protection of stomach tissue from stomach acid, but this leads to the risk of stomach damage when either accepted by itself. A chance to damage the stomach. This risk is greater than the use of higher doses of the drug itself. Users of both drugs simultaneously, in therapyThey had twice as likely to have problems such as stomach perforation, stomach bleeding and ulcers. Together, these drugs can be considered dangerous, even at relatively low doses.

Aspirin is sometimes used for a protective effect that can have on the heart, based on its ability to prevent blood cells from clotting inside the bloodstream. Studies have shown that this effect, which is due to inhibition of Aspirin COX-1, is prevented when naproxen and aspirin are performed within two hours of each other. People using aspirin to prevent infarcts may not gain this beneficial effect if both drugs are used in a short period of time.

The similarities of naproxen and aspirin in their oaks F mechanisms mean that they also have similar side effects. Potential side effects may increase severity and frequency when used simultaneously. Less severe side effects that may result from thatThe combination may include nausea, heartburn and stomach.

medical assistance should be immediately sought if more serious side effects occur after the adoption of one or both drugs. Blood in urine or stool, stomach pain or persistent fever are effects that can potentially result from these drugs. They may testify to serious health conditions such as stomach bleeding. As stated by the above -mentioned studies, these effects are more likely to occur if both drugs are taken together.