Is it safe to combine Mirtazapine and Citalopram?

Mirtazapine and citalopram are antidepressant drugs that affect chemical serotonin that secrete the mood in the brain. In general, large depressive disorders are prescribed, but citalopram can also be used to treat some anxiety disorders. These drugs should not be combined except for the doctor's commands. Although the exact effects of the combination of mirtazapine and citalopram have not been studied extensively, no two drugs that affect serotonin levels have the potential to cause serotonin syndrome. The risks of other, less severe side effects may also be increased. Since both drugs generally have very similar effects, it is often better to increase the dosage of one than to combine them together.

Citalopram, sold under the Celexa® brand, is a selective drug inhibitor serotonin (SSRI), which means that the neurotransmitter serotonin in reabsorbing into the blood attack so quickly. Since 2011 SSRI Drugs has been the most commonly prescribed form of antidepressants in the US for it for itICH generally low incidence of side effects. Mirtazapine, often sold as Remeron®, affects other neurotransmitters such as noradrenaline and serotonin.

Mirtazapine and citalopram affect serotonin levels by various mechanisms, but the final result of both is more free serotonin in the brain. In general, it is unpredictable to combine two drugs that affect the levels of serotonin due to the risk of serotonin syndrome-potentially life-threatening condition. Symptoms of serotonin syndrome include extreme agitations, dizziness, increased heart rate, loss of coordination and diarrhea. Anyone who suspects that he or she can have serotonin syndrome should seek immediate medical care.

The combination of mirtazapine and citalopram may also increase the occurrence of side effects, which is generally mild, but may include drowsiness or dizziness. Patients who take one medicine are recommended, andwould avoid driving or operation of heavy machines until they can find out what effects they will have. The combination of these two drugs significantly increases the chance of these or other side effects disrupting normal functioning.