What Are Earache Drops?

The main ingredients of this product are: Ofloxacin.
Chemical name: (±) -9-fluoro-2,3-dihydro-3-methyl-10- (4-methyl-1-piperazinyl) -7-oxo-7H-pyrido [1, 2,3-de]-[1,4] benzoxazine-6-carboxylic acid.
Chemical Structure:

Ofloxacin ear drops, the indication is for the treatment of otitis media, external auditory canalitis, and tympanitis caused by sensitive bacteria.

Drug Name: Ofloxacin ear drops

Drug type: Prescription drugs, external medicines, essential medicines, medicines for medical workers' injuries
Use classification: ENT medicine

Ofloxacin ear drops composition

Molecular formula: C ₁₈ H ₂₀ FN ₃ O ₄
Molecular weight: 361.38

Ofloxacin Ear Drop Properties

This product is a pale yellow-green clear liquid.

Ofloxacin ear drops indication

Used to treat otitis media, external auditory canalitis, and tympanitis caused by sensitive bacteria.

Ofloxacin ear drops specifications

5ml: 15mg

Ofloxacin Ear Drops Usage and Dosage

Ear drops. Adults 6 to 10 drops at a time, 2 to 3 times a day. After ear dropping, perform an ear bath for about 10 minutes. Increase or decrease the number of ear drops according to symptoms. Decrease the number of drops in children.

Ofloxacin ear drops adverse reactions

Occasionally middle ear pain and itching.

Ofloxacin ear drops contraindications

Patients allergic to this product and fluoroquinolones are contraindicated.

Ofloxacin Ear Drops Precautions

1. Only used to point ears.
2. This product is generally suitable for local treatment of otitis media confined to the middle ear mucosa. If inflammation has spread around the tympanic cavity, oral preparations should be taken in addition to local treatment.
3 If the temperature of the medicine is too low when using this product, it may cause dizziness. Therefore, the use temperature should be close to body temperature.
4 Discontinue medication immediately when symptoms of allergy occur.
5. The course of treatment with this product is limited to 4 weeks. It should be used with caution when continued administration.

Ofloxacin ear drops for pregnant and lactating women

Use with caution in pregnant women.

Ofloxacin ear drops for children

Generally not used for infants.

Ofloxacin ear drops for elderly

still uncertain.

Ofloxacin ear drops drug interactions

After long-term extensive use after local absorption, it can produce the same drug interactions as systemic medications, such as increasing blood concentrations of cyclosporine, probenecid and other drugs, and interfering with caffeine metabolism.

Ofloxacin ear drops drug overdose

still uncertain.

Ofloxacin Ear Drops Pharmacology and Toxicology

This product has a broad-spectrum antibacterial effect, especially has high antibacterial activity against aerobic gram-negative bacilli, and has good antibacterial effect on the following bacteria in vitro: most bacteria of the family Enterobacteriaceae, including Citrobacter, cloaca, gas-producing Enterobacter, such as Enterobacter, Escherichia coli, Klebsiella, Proteus, Salmonella, Shigella, Vibrio, Yersinia, etc. Often has antibacterial activity against multiple drug-resistant bacteria. Penicillin-resistant Neisseria gonorrhoeae, the enzyme-producing influenzae bacterium and Moraxella all have high antibacterial activity. It has antibacterial effect on most strains of Pseudomonas, such as Pseudomonas aeruginosa. This product has antibacterial activity against methicillin-sensitive Staphylococcus, and only moderate antibacterial activity against Streptococcus pneumoniae, Streptococcus hemolyticus and Enterococcus faecalis. It has good anti-microbial effect on Chlamydia trachomatis, Mycoplasma and Legionella, and it also has antibacterial activity against Mycobacterium tuberculosis and atypical Mycobacterium. Poor antibacterial activity against anaerobic bacteria.

Ofloxacin is a bactericide, which acts on the A subunit of bacterial DNA helicase to inhibit DNA synthesis and replication and cause bacterial death.

Pharmacokinetics of ofloxacin ear drops

According to the literature, adult patients drip 0.3% ofloxacin solution into the middle ear cavity, 10 drops at a time, twice a day, for a total of 14 times. After 30 minutes of ear bath, the blood concentration is very low, ranging from 0.009 to 0.012 mg / ml. Pediatric patients dipped their ears once in the middle ear cavity. Five drops of 0.3% ofloxacin aqueous solution were used in the ear bath. After 120 minutes, the serum concentration was low, not exceeding 0.013 g / ml.

Ofloxacin Ear Drop Storage

Protected from light and sealed.

Ofloxacin ear drops packaging

Low density polyethylene medicinal eye drop bottle, 5ml / piece.

Offloxacin ear drops

24 months

Ofloxacin Ear Drops

"Chinese Pharmacopoeia" 2005 edition two