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Laberolol hydrochloride injection is suitable for the treatment of various types of hypertension, especially hypertension crisis. It is also suitable for hypertension with coronary heart disease and hypertension with a history of angina pectoris or heart failure. 2. Suitable for controlling blood pressure before surgery. 3. It is suitable for antihypertensive treatment of pheochromocytoma. 4, applicable to pregnancy-induced hypertension.

Laberolol hydrochloride injection is suitable for the treatment of various types of hypertension, especially hypertension crisis. It is also suitable for hypertension with coronary heart disease and hypertension with a history of angina pectoris or heart failure. 2. Suitable for controlling blood pressure before surgery. 3. It is suitable for antihypertensive treatment of pheochromocytoma. 4, applicable to pregnancy-induced hypertension.

Drug Name

Laberolol Hydrochloride Injection

Drug type

prescription

Special medicine

Doping

Use classification

Sympathetic inhibitor

Labelol hydrochloride injection ingredients

The main ingredient of this product is labelol hydrochloride, and its chemical name is 5- [1-hydroxy-2 (1-methyl-3 phenylpropylamino) -ethyl] salicylamide hydrochloride.
Its structural formula is:

Molecular formula: C ₁₉ H ₂₄ N ₂ O ₃ · HCl
Molecular weight: 364.87
Excipients: glucose (for injection), propylene glycol, water for injection.

Characters of Labelol Hydrochloride Injection

This product is a clear, colorless liquid.

Indications of Labelol Hydrochloride Injection

1. Suitable for treating various types of hypertension, especially hypertension crisis. It is also suitable for hypertension with coronary heart disease and hypertension with a history of angina pectoris or heart failure.
2. Suitable for controlling blood pressure before surgery.
3. It is suitable for antihypertensive treatment of pheochromocytoma.
4, applicable to pregnancy-induced hypertension.

Laberolol Hydrochloride Injection Specifications

10ml: 50mg

Laberolol hydrochloride injection dosage

1. Intravenous bolus: 25 ~ 50mg (1 / 2-1 sticks) plus 20% glucose injection 20m1 at a time, slowly bolus within 5 to 10 minutes, if the blood pressure is not satisfactory, it can be repeated once after 15 minutes, Until the ideal pressure reduction effect is produced. The total dose should not exceed 200 mg (4 sticks), and the maximum effect usually occurs within 5 minutes after the bolus, which is maintained for about 6 hours.
2. Intravenous infusion: 100mg (2) of this product is diluted with 5% glucose injection or 0.9% sodium chloride injection to 250 m1, and the intravenous infusion rate is 1 to 4mg / min until good results are achieved. , And then stop instillation, the effective dose is 50-200mg (1-4), but for patients with pheochromocytoma may require more than 300mg (6).

Adverse Reactions of Labelol Hydrochloride Injection

Occasionally dizziness, gastrointestinal upset, fatigue, paresthesia, exacerbation of asthma, etc. Individual patients have orthostatic hypotension.

Contraindications of Laberolol Hydrochloride Injection

1, disabled patients with bronchial asthma.
2. Cardiogenic shock and cardiac block (II-III degree AV block) are disabled.
3, severe or acute heart failure, sinus bradycardia and other patients are disabled.
4. Those who are allergic to this product are prohibited.

Precautions for Laberolol Hydrochloride Injection

1. It should be used with caution in the following cases: history of allergies, congestive heart failure, diabetes, emphysema or non-allergic bronchitis, liver insufficiency, hypothyroidism, Raynaud's syndrome or other peripheral vascular disease, and renal failure.
2. Intravenous medication should be in the supine position. Do not go too fast during infusion to prevent blood pressure from falling too fast. After injection, lie still for 10-30 minutes.
3, athletes use with caution.

Labelol hydrochloride injection for pregnant and lactating women

This product can be safely and effectively used for pregnancy-induced hypertension, and does not affect the growth and development of the fetus. The concentration in the milk is 22 to 45% of the maternal blood, and it has no side effects on the lactating infant.

Labelol hydrochloride injection for children

still uncertain.

Labelol hydrochloride injection for the elderly

still uncertain.

Labelolol Hydrochloride Injection Drug Interactions

1. Simultaneous application of this medicine and tricyclic antidepressants can cause tremor.
2. This product can reduce the reflective tachycardia of nitroglycerin, but the antihypertensive effect can be synergistic.
3. Use caution with Verapamil calcium antagonists.
4. This product can enhance the effect of halothane on blood pressure.

Labetolol Hydrochloride Injection Overdose

still uncertain.

Laberolol Hydrochloride Pharmacology and Toxicology

1. Pharmacology This product has selective 1 and non-selective receptor antagonism, both effects have a hypotensive effect, the ratio of the two effects during intravenous injection is about 1: 6.9. At high doses, it has membrane stabilization and little endogenous sympathomimetic activity. The antihypertensive intensity of this product is related to the dose, without reflex tachycardia and bradycardia, the blood pressure in the standing position is lower than that in the supine position.
2. Toxicology The median lethal dose (LD50) of this product is 51.8 ± 1.9mg / kg. Rabbits were given an intravenous injection of 1 to 10 mg / kg daily, and no significant toxicity was observed during long-term observation.

Pharmacokinetics of Laberolol Hydrochloride Injection

The binding rate to protein in plasma is about 50%. Most drugs are metabolized in the liver. The half-life (T _1/2 )) is 6 to 8 hours, and its original drugs and metabolites are excreted from the urine. Hemodialysis and peritoneal dialysis are not easy to clear. Vd is 11.2L / kg.

Laberolol Hydrochloride Injection Storage

Shaded and sealed.

Labelol hydrochloride injection packaging

Ampoule bottle: 5 pcs / box

Validity of Laberolol Hydrochloride Injection

Tentative 24 months.

Laberol hydrochloride injection standard

Landmarks of chemical drugs have been upgraded to the national standard of the National Drug Standard Book WS-10001 (HD-0659) -2002 ^[1]