What Are the Different Types of Amitriptyline Tablets?

Amitriptyline hydrochloride is an indication for the treatment of various depressions. This product has a strong sedative effect and is mainly used for the treatment of anxiety or agonistic depression.

Drug Name: Amitriptyline Hydrochloride Tablets

Drug type: Prescription medicines, essential medicines, medicines for medical workers' injuries
Use classification: Tricyclic

Amitriptyline Hydrochloride Tablets Ingredients

The main ingredients of this product are: amitriptyline hydrochloride. Its chemical name is: N, N-dimethyl-3- [10,11-dihydro-5H-dibenzo [a, d] cycloheptatrien-5-ylidene] -1-propylamine hydrochloride .
Chemical Structure:

Molecular formula: C ₂₀ H ₂₃ N · HCl
Molecular weight: 313.87

Traits of Amitriptyline Hydrochloride Tablets

This product is a sugar-coated tablet, which appears white after removing the coating.

Indications of Amitriptyline Hydrochloride

It is used in the treatment of various depressions. The sedative effect of this product is strong. It is mainly used in the treatment of anxiety or inflammatory depression.

Amitriptyline Hydrochloride Tablets Specifications

25mg

Amitriptyline hydrochloride dosage and dosage

oral. The usual dosage for adults is 25mg (1 tablet) once, 2 to 3 times a day, and then gradually increased to 150-250mg (6 to 10 tablets) a day, 3 times a day according to the condition and tolerance. Over 300 mg (12 tablets), the maintenance amount is 50 to 150 mg (2 to 6 tablets) per day.

Amitriptyline hydrochloride adverse reactions

At the beginning of treatment, anticholinergic reactions may occur, such as sweating, dry mouth, blurred vision, difficulty urinating, and constipation. Central nervous system adverse reactions can appear lethargy, tremor, dizziness. Orthostatic hypotension can occur. Occasionally seizures, bone marrow suppression and toxic liver damage.

Amitriptyline hydrochloride taboo

People with severe heart disease, recent history of myocardial infarction, epilepsy, glaucoma, urinary retention, hyperthyroidism, liver damage, and allergies to tricyclic drugs.

Precautions for amitriptyline hydrochloride tablets

Use with caution in patients with severe liver and kidney dysfunction, enlarged prostate, and elderly or cardiovascular disease patients. The ECG should be monitored during use. This product should not be used in combination with a monoamine oxidase inhibitor. It should be used 14 days after the monoamine oxidase inhibitor is stopped. Patients should discontinue treatment immediately when they have a tendency to turn to mania. It is not advisable to drive vehicles, operate machinery or work at height during medication.

Amitriptyline hydrochloride tablets for pregnant and lactating women

Use with caution in pregnant women. Breastfeeding women should stop breastfeeding during use.

Amitriptyline hydrochloride tablets for children

Children under 6 years are disabled. Children over 6 years of age reduce as appropriate.

Amitriptyline hydrochloride tablets for elderly

Start with a small dose and reduce the dose as appropriate.

Amitriptyline hydrochloride drug interactions

1. This product is used in combination with sutopril, which may increase the risk of ventricular arrhythmias, and can be severe to the tip to reverse the arrhythmia.
2. This product is combined with ethanol or other central nervous system inhibitory drugs, and the central nervous system inhibitory effect is enhanced.
3. This product is used in combination with epinephrine and norepinephrine, which can easily cause hypertension and arrhythmia.
4. This product is used in combination with clonidine, the latter has reduced antihypertensive effect.
5. This product combined with anticonvulsants can reduce the effect of anticonvulsants.
6. This product combined with fluoxetine or fluvoxamine can increase the plasma concentration of both, convulsions and increased adverse reactions.
7. This product is used in combination with atropine to increase adverse reactions.
8. Combined with monoamine oxidase, hypertension can occur.

Amitriptyline hydrochloride overdose

Symptoms of poisoning: irritability, delirium, coma, severe anticholinergic reactions or seizures. Cardiotoxicity can cause conduction disorders, arrhythmias, and heart failure.
Treatment: gastric lavage, induce vomiting to eliminate poison, increase excretion measures, and carry out corresponding symptomatic treatment and supportive therapy according to the condition.

Pharmacology and Toxicology of Amitriptyline Hydrochloride Tablets

This product is a tricyclic antidepressant, and its effect is to inhibit the reuptake of serotonin and norepinephrine. It has a stronger inhibition of serotonin reuptake, and has a stronger sedative and anticholinergic effect.

Pharmacokinetics of amitriptyline hydrochloride tablets

Oral absorption is good, bioavailability is 31% to 61%, protein binding rate is 82% to 96%, half-life (t _1/2 ) is 31 to 46 hours, and apparent volume of distribution (V _d ) is 5 to 10 L / kg. It is mainly metabolized in the liver. The active metabolite is nortriptyline, which is excreted from the kidney and can be secreted into breast milk. Due to the decreased metabolism and excretion ability of elderly patients, the sensitivity to this product should be increased, and the dosage should be reduced. Patients with liver cirrhosis and portal surgery, and patients with renal failure need to reduce the amount.

Storage of amitriptyline hydrochloride tablets

Shaded and sealed.

Packaging of amitriptyline hydrochloride tablets

Medical high-density polyethylene plastic bottle, 100 tablets / bottle.

Amitriptyline hydrochloride expiration date

24 months.

Implementation of amitriptyline hydrochloride tablets

"Chinese Pharmacopoeia" 2010 edition two. ^[1]