What Are the Different Types of Omeprazole Capsules?

Omeprazole capsules are suitable for gastric ulcer, duodenal ulcer, stress ulcer, reflux esophagitis and Zhuo-Ellison syndrome (gastrinoma). ^[1] .

Drug Name: Omeprazole capsules
Hanyu Pinyin: Ao Mei La Zuo Jiao Nang

Drug type: Work Injury Medical Insurance Class A Double Span
Use classification: Drugs that inhibit gastric acid secretion

Omeprazole capsule ingredients

Omeprazole

Omeprazole capsule properties

This product is a capsule and its contents are white pellets.

Omeprazole capsule indications

Applicable to gastric ulcer, duodenal ulcer, stress ulcer, reflux esophagitis and Zhuo-Ai syndrome (gastrinoma).

Omeprazole capsule specifications

20mg

Omeprazole capsules dosage

Taken orally, do not chew.
1. Peptic ulcer: 20mg once (1 tablet at a time), 1 or 2 times a day. Swallow in the morning or once every morning and evening. The course of gastric ulcer is usually 4 to 8 weeks, and the course of duodenal ulcer is usually 2 to 4 weeks.
2. Reflux esophagitis: 20 ~ 60mg once (1 ~ 3 tablets at a time), 1 ~ 2 times a day. Swallow in the morning or once in the morning and evening, usually for 4 to 8 weeks.
3 Zhuo-Ai Syndrome: 60mg once (3 capsules at a time), once a day. The total daily dose can be adjusted to 20 120mg (1 6 capsules) according to the condition. If the total daily dose needs to exceed 80mg (4 capsules) ), Should be taken in two doses.

Omeprazole capsule adverse reactions

This product is well tolerated. Common adverse reactions are diarrhea, headache, nausea, abdominal pain, flatulence and constipation, occasionally increased serum aminotransferase (ALT, AST), rash, dizziness, lethargy, insomnia, etc. These adverse reactions It is usually mild and disappears irrespective of the dose. Long-term treatment has not seen serious adverse reactions, but in some cases gastric mucosal cell proliferation and atrophic gastritis can occur.

Omeprazole capsules contraindications

Allergic to this product, severe renal insufficiency and infants and young children are prohibited.

Omeprazole capsules precautions

1. When treating gastric ulcer, the possibility of ulcerative gastric cancer should be ruled out first, because the treatment with this product can reduce its symptoms and delay the treatment.
2. Patients with liver and kidney dysfunction should be used with caution.
3 This product is an enteric-coated capsule. Be careful not to chew it when taking it, so as not to release the drug prematurely in the stomach and affect the efficacy.

Omeprazole capsules for pregnant and lactating women

Although animal experiments show that this product has no fetal toxicity or teratogenic effects, it is generally not used for pregnant women and should be used with caution in lactating women.

Omeprazole capsules for children

There is no medication experience for children, infants and young children are disabled.

Omeprazole capsule drug interactions

This product can delay the elimination of drugs metabolized by the liver in the body, such as diazepam, phenytoin, warfarin, nifedipine, etc. When this product is used together with the above drugs, the amount of the latter should be reduced.

Omeprazole capsules pharmacology and toxicology

Proton pump inhibitor. This product is a fat-soluble weakly alkaline drug that is easily concentrated in acidic environments, so it can be specifically distributed in the secretory tubules of gastric mucosal cells after oral administration, and converted into the active form of sulfinamide in this high-acid environment Then, through a disulfide bond, it irreversibly combines with the sulfhydryl group of the H ⁺ , K ⁺ -ATPase (also known as the proton pump) in the parietal cell secretion membrane to form a complex of sulfinamide and proton pump, thereby inhibiting the enzyme Activity, the last step to block gastric acid secretion, so this product has a strong and lasting inhibitory effect on gastric acid secretion caused by various reasons.

Omeprazole capsule pharmacokinetics

After oral administration, the product is absorbed through the small intestine and takes effect within 1 hour. The blood concentration reaches a peak within 0.5 to 3.5 hours. The effect lasts for more than 24 hours and can be distributed to liver, kidney, stomach, duodenum, thyroid and other tissues Easy to pass through the placenta. Usually single-dose bioavailability is about 35%, multi-dose bioavailability is increased to about 60%, plasma protein binding rate is 95% to 96%, plasma half-life is 0.5 to 1 hour, and chronic liver disease is 3 hours. This product is metabolized by the liver microsomal cytochrome P450 oxidase system in the body. About 80% of the metabolites are excreted in the urine, and the rest are excreted from the feces after being secreted by the bile.