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This product is white or off-white powder or crystalline powder; odorless; slightly bitter; easy to attract moisture. This product is soluble in water, slightly soluble in methanol, and almost insoluble in ethanol, acetone or benzene. The specific rotation is taken from this product, accurately weighed, dissolved in water and diluted to a solution containing 50 mg per 1 ml, and measured according to law. The specific rotation is -18 degrees to -24 degrees. The absorption coefficient is taken from this product, accurately weighed, dissolved in water and diluted to a solution containing about 16 g per 1 ml. According to spectrophotometry, the absorption coefficient is measured at a wavelength of 272 nm, and the absorption coefficient is 264-292.
Cefazolin sodium
- This product is white or off-white powder or crystalline powder; odorless; slightly bitter; easy to attract moisture. This product is in water
- [Name] Cefazolin sodium
- [Alias] Cephalosporin V, Cefazolin,
- Its sodium salt is commonly used as a white or off-white crystalline powder. It is odorless, bitter, and easily soluble in water.
- Clinically applicable to those caused by sensitive bacteria
- Usual Adult Dose:
- Slow intravenous bolus, intravenous drip, or
- 1. Low toxicity, right
- The following reactions may occur: allergic reactions: rash, urticaria, increased eosinophils, drug fever and other allergic reactions; kidney toxicity:
- Correct
- Injection: 0.5g, 1.0g
- People who are allergic to cephalosporin and have
- Keep tightly closed in a cool, dark and dry place.
- English name CefazolinSodiumforInjection
- Category: Western medicine
Cefazolin sodium pharmacological effects
- Cefazolin is the first-generation cephalosporin and has a broad antibacterial spectrum. Except for Enterococcus and Methicillin-resistant Staphylococcus, this product is positive for other Grams
- Cefazolin sodium
Cefazolin sodium kinetics
- After intramuscular injection of 500 mg of this product, the peak plasma concentration (Cmax) reached 38 mg / L (32 to 42 mg / L) in 1 to 2 hours, and the blood drug concentration in 6 hours was still 7 mg / L. Intravenous infusion of 0.5 g of this product within 20 minutes, peak blood drug concentration was 118 mg / L, and the effective concentration was maintained for 8 hours. This product is difficult to penetrate the blood-cerebrospinal fluid barrier, and drug concentrations cannot be measured in the cerebrospinal fluid. Cefazolin can reach higher concentrations in pleural fluid, ascites, pericardial fluid, and bursal fluid. The drug concentration in the inflammatory exudate was basically equal to the serum concentration; the concentration in the bile was equal to or slightly exceeded the blood drug concentration over the same period. The fetal blood concentration is 70% to 90% of the maternal blood concentration, and the content in milk is low. The protein binding rate of this product is 74% to 86%. The blood elimination half-life (T1 / 2a) of normal adults is 1.5 to 2 hours, which can be extended to 2.5 hours in the elderly. T1 / 2a in patients with renal failure can be prolonged, and endogenous creatinine clearance is 12-17 ml / min and 12 hours and 57 hours below 5 ml / min, respectively. The T1 / 2a of newborns within one week of birth is 4.5 to 5 hours. This product is not metabolized in the body; the original drug is filtered through the glomerulus, and part of it is excreted from the urine through the renal tubules. 80% to 90% of the dose can be discharged within 24 hours. Probenecid can increase the plasma concentration by about 30% and prolong the effective plasma concentration time. After 6 hours of hemodialysis, the blood drug concentration is reduced by 40% to 50%; peritoneal dialysis cannot generally clear this product.
Cefazolin sodium indication
- It is suitable for the treatment of respiratory infections such as otitis media, bronchitis, pneumonia caused by sensitive bacteria, urinary tract infections, skin and soft tissue infections, bone and joint infections, sepsis, infective endocarditis, hepatobiliary infections, and eye, ear, nose, Throat and other infections. This product can also be used as a preventive medicine before surgery. This product should not be used for central nervous system infection. For chronic urinary tract infections, especially those with abnormal anatomy of the urinary tract are less effective. This product is not suitable for the treatment of gonorrhea and syphilis.
Cefazolin sodium dosage
- Commonly used doses for adults: slow intravenous injection, intravenous drip or intramuscular injection, 0.5-1 g once a day, 2 or 4 times a day, severe infection can be increased to 6 g a day, divided into 2 to 4 intravenous administrations. Commonly used doses for children: 50-100mg / kg per day, divided into 2-3 slow intravenous boluses, intravenous drip or intramuscular injection. When the creatinine clearance rate of the patients with impaired renal function is greater than 50ml / min, they can still be administered at the normal dose. 0.5g every 8 hours when creatinine clearance is 20-50ml / min; 0.25g every 12 hours when creatinine clearance is 11-34ml / min; 0.25g every 18-24 hours when creatinine clearance is less than 10ml / min . The first dose for all patients with varying degrees of renal failure was 0.5 g. When children with impaired renal function are given cefazolin, they should first be given 12.5mg / kg, followed by the maintenance amount. When the creatinine clearance rate is above 70ml / min, they can still be given at the normal dose. 12.5-30mg / kg every 12 hours; 3.1-12.5mg / kg every 12 hours when the creatinine clearance rate is 20-40ml / min; and every 24 hours when the creatinine clearance is 5-20ml / min Weight 2.5-10mg / kg. This product is used to prevent infection after surgery. Generally, it is administered intramuscularly or intravenously at a dose of 0.5 g for 1 to 1 hour before surgery. If the operation time exceeds 6 hours, 0.5 to 1 g is added intraoperatively, and 0.5 for every 6 to 8 hours after surgery. 1g, until 24 hours after surgery.
Cefazolin sodium adverse reactions
- The incidence of adverse reactions is low.
- 1. Thrombophlebitis and intramuscular injection area pain caused by intravenous injection are less and milder than ceftiophen.
- 2. The incidence of drug rash was 1.1%, and the incidence of eosinophilia was 1.7%, with occasional drug fever.
- 3. Individual patients may have transient elevated serum aminotransferase and alkaline phosphatase.
- 4. Encephalopathy may occur in patients with impaired renal function when using high doses (12g daily) of this product.
- 5. Occasional secondary infection of Candida albicans.
- Contraindications: This product is contraindicated for those who are allergic to cephalosporins and those who have a history of anaphylactic shock or immediate reactions to penicillin.
Cefazolin sodium precautions
- 1. Those who are allergic to penicillin or allergies should use it with caution.
- 2. Approximately 1% of patients taking the drug may have direct and indirect Coombs test positive and urine glucose false positive reactions (copper sulfate method). This product is not recommended for premature infants and newborns under 1 month. The milk content of this product is low, but breastfeeding women should still pause breastfeeding. T1 / 2 of this product is significantly longer in the elderly than in the young, and it should be appropriately reduced or extended according to renal function.
- Overdose treatment of this product has no specific antagonists. When the drug is overdose, symptomatic treatment and a large amount of water and fluid replacement are mainly given.
Cefazolin sodium interaction
- 1. This product is contraindicated with the following drugs. Do not infuse in the same bottle: amikacin sulfate, kanamycin sulfate, chlortetracycline hydrochloride, oxytetracycline hydrochloride, tetracycline hydrochloride, erythromycin gluconate, polysulfate Colistin B, colistin sodium mesylate, pentobarbital, calcium gluconate, calcium gluconate.
- 2. This product can be combined with gentamicin or amikacin to enhance antibacterial effect in vitro.
- 3. The combination of this product with strong diuretics may increase renal toxicity, and the combination with aminoglycoside antibiotics may increase the latter's renal toxicity.
- 4. Probenecid can increase the blood concentration of this product and prolong the blood half-life.
- The preparation is calculated according to C14H14N8O4S3 (1) 0.5g (2) 1.0g