What Are the Uses of Azelastine Nasal Spray?

Azelastine hydrochloride nasal spray, the indication is Seasonal Allergic Rhiniti (SAR), Perennial Allergic Rhinitis (PAR)

Drug Name: Azelastine Hydrochloride Nasal Spray

Drug type: Prescription drugs, topical drugs, medical insurance workers' injuries
Use classification: ENT medicine

Azelastine Hydrochloride Nasal Spray Ingredients

The main ingredient of this product is: Azelastine hydrochloride. Its chemical name is: (left and right) -4- (chlorophenyl) methyl-2- (hexahydro-1-methyl-1H-cyclohexyl-4- Amine)-(2H) -diazonaphthone hydrogen chloride Its structural formula is:

Molecular formula: C ₂₃ H ₂₄ CIN ₃ O · HCl
Molecular weight: 418.37

Characters of Azelastine Hydrochloride Nasal Spray

This product is a colorless or almost colorless clear liquid.

Indications of Azelastine Hydrochloride Nasal Spray

Seasonal Allergic Rhiniti (SAR)
Perennial Allergic Rhinitis (PAR)

Specifications of Azelastine Hydrochloride Nasal Spray

10ml: 10mg

Aztrostine hydrochloride nasal spray

1 spray / nostril, once in the morning and evening, twice daily (equivalent to a dose of 0.56 mg of azelastine hydrochloride per day) or as directed by your doctor. Keep your head upright when spraying. (See how to use)
Before the symptoms disappear, acepine nasal spray should be used continuously, but the continuous use should not exceed 6 months.

Azelastine Hydrochloride Nasal Spray Adverse Reactions

Nasal mucosal irritation occurs in a small number of patients when spraying, and nausea occurs in some patients. If the method of administration is incorrect (for example, the head is tilted back), the medicine will have a bitter taste, and occasionally nausea may occur.

Azelastine hydrochloride nasal spray contraindications

Patients who are highly sensitive to azelastine hydrochloride and edetic acid are contraindicated, and children under 6 years are contraindicated.

Precautions for Azelastine Hydrochloride Nasal Spray

See [Medication for pregnant and lactating women]

Aztrostine hydrochloride nasal spray for pregnant and lactating women

Although super-dose tests on animals have not produced abnormal reactions to the drug, it is not recommended for women in the 3 months before pregnancy. It is strictly forbidden to use this product by nursing mothers.

Azelastine Hydrochloride Nasal Spray for Children

Children over 6 years old use the same dosage as adults.

Azelastine hydrochloride nasal spray for the elderly

See usage and dosage.

Azelastine Hydrochloride Nasal Spray Drug Interactions

No interactions were found with other drugs.

Azelastine Hydrochloride Nasal Spray Drug Overdose

Animal tests have shown that excessively high oral doses can cause symptoms of the central nervous system. Once this occurs, there is no specific antidote for symptomatic treatment or supportive therapy.

Azelastine Hydrochloride Nasal Spray Pharmacology and Toxicology

Azelastine hydrochloride is a new structured derivative of 2,3 diazanaphthone, which is a potential long-acting anti-allergic compound with H ₁ receptor antagonist characteristics. Animal experimental data show that high concentrations of azelastine hydrochloride can prevent the synthesis and release of certain chemical mediators in allergic reactions (for example: leukotriene, histamine, serotonin)
When administered by nasal spray, no local or organ-specific toxicity was detected at the maximum dose allowed.

Pharmacokinetics of Azelastine Hydrochloride Nasal Spray

General characteristics:
After oral administration, azelastine hydrochloride was quickly absorbed by the body, with an absolute bioavailability of 81%. Food has no effect on absorption. The high volume of the distribution indicates that the distribution is mainly in the surrounding tissues, and the protein structure level is relatively low (80% -90%). After the single-agent administration of azelastine hydrochloride, the plasma clearance half-life of azelastine hydrochloride is 20 hours. Therapeutic activity The metabolite N-Desmethyl azelastine is about 45 hours. Excretion is mainly eliminated through feces. Persistent excretion of small amounts of drugs in stool indicates that the drugs can enter the enterohepatic circulation. Repeatedly daily nasal spray of 0.56 mg of azelastine hydrochloride (equivalent to 1 spray / per nostril, 2 times / day), the steady-state plasma concentration of azelastine hydrochloride of healthy volunteers was 0.27ng / ml, and its activity The metabolite N-Desmethyl azelastine can be detected at or below the quantitative limit (0.12ng / ml).
Patient characteristics:
After repeated application of the drug in patients with allergic rhinitis, the level of plasma azelastine hydrochloride is slightly higher than that of healthy people, which indicates that the level of drug absorption throughout the body is high (mainly because the drug can penetrate the inflamed nasal mucosa well, which is convenient for absorption). ). After a total daily dose of 0.56 mg / ml of azelastine hydrochloride (for example: 1 spray / per nostril, 2 times / day), the average plasma concentration of azelastine was observed to be approximately 0.65 ng / ml after 2 hours of administration. The dosage of azelastine hydrochloride is doubled daily to 1.12 mg (for example: 2 sprays / nostril, 2 times / day). The average plasma concentration of azelastine is 1.09 ng / ml. This shows that the concentration of medication is proportional to the dose of medication. Although the patient's level of drug absorption was relatively high, the systemic drug exposure level for nasal medications was calculated to be approximately 8 times lower than the systemic drug exposure level for oral medications (the oral dose for allergic rhinitis was 4.4 mg azelastine hydrochloride).

Azelastine Hydrochloride Nasal Spray Storage

The storage temperature is above 8 ° C.

Aztrostine Hydrochloride Nasal Spray Packaging

10ml / 1 bottle / box

Validity of Azelastine Hydrochloride Nasal Spray

The validity period is 3 years. ^[1]