What Are the Pros and Cons of ICSI for Infertility?

ICSI (Intracytoplasmic sperm injection) is the intracytoplasmic sperm microinjection technology, which is also the second generation of "test tube baby". This technology uses a micro operating system to inject a single sperm into an egg to fertilize it. It was developed on the basis of various micro-insemination techniques such as zona pellucida drilling, partial resection of the zona pellucida, and infertility in the zona pellucida. In 1992, Palerme et al. Introduced the first IVF insemination. Since then, the scope of ICSI technology has become wider and wider ^[1] .

Due to the influence of social and environmental factors, the quality of semen shows a downward trend, and infertility caused by male factors is also increasing. In order to solve the problems that IVF technology can not solve, such as severe oligospermia, micro-assisted insemination technology, namely intracytoplasmic sperm injection (ICSI), was born ^[1]

The mammalian ICSI test was studied relatively late. The first ones involved were Uehara and Yanagimachi (1976). They proved through experiments that the fusion of male and female gamete plasma membranes is not a necessary condition for nuclear compaction and prokaryotic formation. In 1988, ICSI research made breakthrough progress, Hosoi et al reported that rabbit ICSI insemination was successful and obtained offspring. In 1995, Limura and Yanagimachi improved the microscopy system and applied the Piezo-driven (piezo-electric micro-manipulation) device to ICSI of mouse eggs, which greatly improved the survival rate of injected eggs. Ahmadi et al. (1995) used Piezo-driven to obtain ICSI offspring of mice with a litter rate of 30%. Michiko et al. (2003) used in vitro mature oocytes to obtain three healthy ICSI piglets. In 1992, Palermo and others successfully applied ICSI to obtain healthy babies. Since then, the history of human infertility treatment in men has turned to a new page. The fertilization rate of intracytoplasmic injection of human sperm can reach 65% to 70%, and the implantation rate of embryos can reach more than 20%. ICSI has developed into an ideal method to solve male infertility ^[2]

1.Severely weak, weak, malformed spermatozoa

2. Unexplained infertility: The fertilization rate of the second-generation "IVF" technology is higher than that of conventional "IVF". For unexplained infertility patients, ICSI technology can be recommended to assist pregnancy.

3. Losers of the previous "IVF" failure: There is evidence that the fertility rate of patients who failed the IVF pregnancy again will not exceed 25%. And using the second-generation "test tube baby" technology to assist pregnancy can achieve a higher success rate.

4. Round head (

1. Both men and women suffer from severe mental illness, acute infection of sexually transmitted diseases of urogenital system.

2. Suffering from hereditary diseases that are not suitable for childbearing as stipulated in the "Mother and Infant Health Care Law" and cannot be genetically diagnosed before embryo implantation.

3. Either party has serious bad habits such as drug use.

4. Either party is exposed to the radiation, poison, medicines that cause the qi, and is in the action period.

5. The woman's uterus does not have pregnancy function or severe physical illness cannot bear pregnancy ^[3]

The success rate of ICSI is greatly influenced by sperm quality preparation and micromanipulation techniques. ICSI plus IVF is the most effective treatment for male infertility, with a live birth rate of 20-25%. Since the first couple successfully gave birth to a daughter using intra-sperm sperm microinjection in 1996, intra-sperm sperm injection has attracted worldwide attention. About 100,000 infertile couples across the country have realized their dream of having their own baby through intracytoplasmic sperm injection.