What Are the Uses of Neomycin and Polymyxin B?

Compound neomycin polymyxin eye drops, designed for the treatment of eye inflammation sensitive to steroids, and at the same time has or is potentially bacterial sensitive to neomycin and / or polymyxin infection. Such as: non-purulent conjunctivitis and blepharitis, scleritis, non-herpetic keratitis, dacryocystitis and eye surgery, foreign body removal, chemical or thermal burns, abrasions, lacerations, or other eye trauma prevention treatment.

Drug Name: Compound neomycin polymyxin eye drops

Drug type: Prescription drugs, external drugs
Use classification: Other ophthalmic drugs

Compound neomycin polymyxin eye drops ingredients

This product is a compound preparation, and its components are:
1. Prednisolone acetate:
The chemical name is: 11b, 11a, 21-trihydroxyprogesterone-1,4-diene-3,20-dione-21-acetate 2. Neomycin sulfate Polymyxin B sulfate
Chemical Structure:

Each ml contains: 5mg prednisolone acetate, 5mg neomycin sulfate (equivalent to 3.5 mg neomycin), 10,000 units of polymyxin sulfate, 14 mg of liquid film component (polyvinyl alcohol), 0.01 mg thimerosal, and vomit Temperature 80, propylene glycol, sodium acetate, pure water.

Properties of Compound Neomycin Polymyxin Eye Drops

White to off-white fine suspension.

Indications of compound neomycin polymyxin eye drops

This product is used to treat ocular inflammation that is sensitive to steroids, and at the same time has or is potentially bacterial infections sensitive to neomycin and / or polymyxin. Such as: non-purulent conjunctivitis and blepharitis, scleritis, non-herpetic keratitis, dacryocystitis and eye surgery, foreign body removal, chemical or thermal burns, abrasions, lacerations, or other eye trauma prevention treatment.

Compound neomycin polymyxin eye drops specifications

Plastic drop bottle with sterile eye drops, 5mL volume.

Compound neomycin polymyxin eye drops usage dosage

Eye treatment: 1 drop each time, every 3-4 hours, if necessary, increase the number of times.
Eyelid treatment: 1 drop at a time, every 3-4 hours, close the eyes, and rub the excess liquid on the eyelids and eyelids.
Skin treatment around the eyes: When the inflammation of the eyes or eyelids is accompanied by inflammation of the surrounding affected skin, apply a few drops on the inflammation surface to make it diffuse and dry naturally.

Adverse reactions of compound neomycin polymyxin eye drops

Perforation can occur with topical use of steroids in patients with conditions that can cause thinning of the cornea.
Other adverse reactions include local irritation and unusual allergic reactions.

Compound neomycin polymyxin eye drops contraindications

It is contraindicated in patients with acute herpes simplex keratitis (dendritic keratitis), cowpox, chickenpox, and various other corneal and conjunctival virus diseases, ocular tuberculosis, ocular fungal disease, and those who are allergic to any component of this product.

Precautions for compound neomycin polymyxin eye drops

When using steroids for microbial-caused diseases, infections can be masked, strengthened, or activated. Long-term topical steroid treatment may cause increased intraocular pressure and cause glaucoma. Damage to the optic nerve, visual impairment and visual field defects may also cause the formation of cataracts under the posterior capsule. It is recommended to measure intraocular pressure frequently. A variety of ocular disorders and long-term topical corticosteroids are known to cause thinning of the cornea and sclera. In cases where corneal or scleral tissue is thin, topical application of steroids can cause perforation. Prolonged use can cause excessive growth of non-sensitive microorganisms. If dual infection occurs, stop using this product and take appropriate treatment measures. If chronic eye inflammation persists after long-term use of corticosteroids, the possibility of a corneal fungal infection should be considered. Topical corticosteroids may delay wound healing. In patients with a history of herpes simplex virus, treatment with corticosteroids requires special care. In the case of acute purulent eyes, corticosteroids may mask infections or exacerbate existing infections. Neomycin sulfate has a potential to cause skin allergic reactions, and its incidence is unknown. Use with caution by athletes.

Compound neomycin polymyxin eye drops for pregnant and lactating women

There are no appropriate and better controlled studies on the use of this product in pregnant women, and the use of this product is considered only during pregnancy if its possible beneficial effects outweigh the possible side effects on the fetus. It is unclear whether topical application of this product can cause absorption and secretion into the milk throughout the body. The importance of the drug to the mother should be considered, and this product should be used with care by lactating women.

Compound neomycin polymyxin eye drops for children

The safety and effectiveness of children's applications have not been established.

Compound neomycin polymyxin eye drops for elderly use

No dosage adjustment is needed for elderly patients.

Compound neomycin polymyxin eye drops drug interactions

Compound neomycin polymyxin eye drops drug overdose

Excessive use usually does not cause an emergency. If you accidentally overdose, flush your eyes with water or saline. If accidentally ingested, dilute by oral liquid.

Compound neomycin polymyxin eye drops pharmacology and toxicology

Pharmacological effects: Prednisolone acetate: Prednisolone acetate is a glucocorticoid, its anti-inflammatory effect is 3-5 times that of hydrocortisone, and it has no synergistic effect on increasing mineralocorticoid activity. Neomycin sulfate: Neomycin sulfate is a broad-spectrum bactericidal aminoglycoside antibiotic that effectively inhibits a variety of Gram-positive and Gram-negative bacteria. Polymyxin B Sulfate: Polymyxin B sulfate is a cyclic lipopeptide antibiotic that can quickly kill various Gram-negative bacteria.
Toxicology study: This product has not been toxicologically studied.

Pharmacokinetics of compound neomycin polymyxin eye drops

Prednisone Acetate: Prednisone Acetate is locally instilled into rabbit eyes and has a long half-life in the cornea and aqueous humor. A comparative study of various commercially available steroid eye drops shows that prednisolone acetate is resistant to The inflammatory activity is strong. When the corneal epithelium is intact, 1% -prednisolone solution produces the highest concentration of corticosteroids in the cornea and aqueous humor of rabbits. Neomycin Sulfate 3: Research on rabbit eye drops of 40mg / mL neomycin sulfate solution has shown that neomycin can be absorbed into aqueous humor. When the cornea is worn, the eye absorbs neomycin and reaches the maximum. Polymyxin Sulphate B3: A report indicates that polymyxin B is not absorbed by dripping into the conjunctival sac. Polymyxin B is used throughout the body. Even in the case of inflammation in the eye, polymyxin B does not penetrate into the aqueous humor of the eye.

Storage of compound neomycin polymyxin eye drops

Store at 15-25 ° C to prevent freezing.

Compound neomycin polymyxin eye drops packaging

Plastic drop bottle of sterile eye drops, 5ml / bottle / box.

Validity of compound neomycin polymyxin eye drops

24 months.

Compound neomycin polymyxin eye drops implementation standards

JX20010354 ^[1]