What Is Probenecid?

Probenecid inhibits the active reabsorption of urate in the proximal tubules, increases excretion of urate and reduces the concentration of urate in the blood. Can alleviate or prevent the formation of urate nodules, reduce joint damage, and promote the dissolution of urate formed. No anti-inflammatory and analgesic effects. It can competitively inhibit the secretion of weak organic acids (such as penicillin and cephalosporins) in the renal tubules, so it can increase the blood concentration of these antibiotics and prolong their action time.

Basic Information

Drug Name

Probenecid Tablets

Dosage form

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Drug type

chemical

Specifications

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Used for:

1. Hyperuricemia with chronic gouty arthritis and gout stones, but glomerular filtration must be greater than 50 ~ 60 ml / min; no history of kidney stones or kidney stones; non-acid urine; people not taking salicylic acid .

2. As an adjunct to antibiotic treatment, it can improve the efficacy of antibiotics.

Oral: 0.25 g / time, 2 times / day, doubled after one week. Used to enhance the effect of penicillins, 0.5 g / time, 4 times / day. For children aged 2 to 14 years or weighing less than 50 kg, the first dose is 0.025 g / kg or 0.7 g / m, and then 0.01 g / kg or 0.3 g / m each time, 4 times a day.

1. The most common gastrointestinal symptoms are nausea, vomiting, abdominal discomfort, and loss of appetite. Can cause stomach ulcers.

2. May have dizziness, headache, facial flushing, frequent urination, rash, etc.

3. Occasionally allergic reactions may have dyspnea, fever, dermatitis and itching of the skin, and occasionally can cause acute gout attacks.

4. Severe adverse reactions such as rare aplastic anemia, hemolytic anemia, leukopenia, bone marrow suppression and liver necrosis. Cross-allergic reactions with sulfa, including rash, itching of the skin, and fever, are rare but rare.

For chronic gout patients must:

1. Glomerular filtration is greater than 50 60ml / min;

2. No history of kidney stones or kidney stones;

3. Non-acidic urine;

4. Those who do not take salicylic acid drugs. Can promote the formation of kidney stones, urine pH should be guaranteed to range from 6.0 to 6.5.

Hyperuricemia with tumor, or patients receiving chemotherapy or radiation therapy, should not use this product, because it can cause acute kidney disease.

Renal dysfunction, those who are allergic to sulfa drugs and those with renal insufficiency are contraindicated.

Should not be equivalent to salicylic acid drugs, aspirin, itanilic acid, hydrochlorothiazide, butamethin, indomethacin, naproxen, allopurinol, sulfa drugs, methotrexate, and oral hypoglycemic drugs Because this product can inhibit the renal tubular excretion of these drugs, so that their effect is enhanced and toxicity increased.

Note: The above content is only for introduction, the drug use must be carried out by a regular hospital under the guidance of a doctor.