What is the connection between metoclopramide and tardive dyskinesia?
The connection between metoclopramide and tardive dyskinesia (TD) is one of the drugs and serious side effects. Metoclopramide has several different uses as antiemetics and as gastrocinetics. Long -term use or high doses of this drug are associated with an increased risk of TD development, a disorder that results in recurring involuntary body movements. As a result of the interconnection between metoclopramide and tardive dyskinesia, the United States of Food and Drug Administration recommends that metoclopramide be used for less than 12 weeks if the advantage is expected to outweigh the risk of TD. In the United States, metoclopramide is sold under the brands of Reglan® and Metozolv OD®.
Metoclopramide is used primarily to treat gastrointestinal disorders and to prevent nausea and vomiting. Diabetic patients may use this medicine to treat gastroparesis because it increases intestinal and stomach contractions, which alleviates symptoms such as heartburn and loss of appetite. Metoclopramide is alsoadministered to individuals with gastroesophageal reflux disease (GERD) because it soothes heartburn, allowing the esophagus injury time to heal.
Chemotherapy and post-surgical patients can take this medicine to prevent nausea and vomiting. It can also be prescribed to people suffering from persistent hiccups and vascular headaches. This medicine is sometimes administered during surgery to protect from the aspiration of fluid into the lungs.
The patient's metoclopramide dose depends on the treated health condition. It is available as a tablet, solution or syrup. Common side effects include drowsiness and dizziness.
It is now known that there is a connection between high doses and long -term treatment of metoclopramide and tardive dyskinesia. The risk of developing TD when using metoclopramide increases when the drug is taken after more than three months. TD is a disorder characterized by involuntary movementsby, usually from the lower face, such as grinning, slapping lips and tongue alerts. Patients with TD may also persecute and reverse the lips and fast eye flashing.
The mechanism in the work between metoclopramide and tardive dyskinesia is not fully understood. It is believed that TD is the result of neuroleptically induced dopamine supersensitivity and that metoclopramide affects the patient's dopamine level. TD is sometimes incorrectly diagnosed as mental than neurological disorder, resulting in a patient given neuroleptic or antipsychotic drugs that only worsen the problem.
As a result of this context between metoclopramide and tardive dyskinesia, the lowest effective dose should be used for less than 12 weeks to reduce the risk of the patient. If TD develops, the first procedure is to stop taking metoclopramide. Symptoms can continue despite the moon withdrawal and letr can be permanent.
patients taking metoclopramide should be vigilant for td signs. SequenceFaces, fingers movement, and jaw swinging are symptoms of disorder. The tongue pushing and repeating chewing or slapping on the lips are also common. Early diagnosis and immediate withdrawal of metoclopramide may reverse the condition, but it is also possible that the symptoms are getting worse and never used.
TD is a serious side effect of drugs other than metoclopramide. It is usually caused by drugs called neuroleptics and older antipsychotic drugs such as chlorpromazine and haloperidol. Newer antipsychotic drugs represent a less chance of developing TDs, but are not risk -free. As with metoclopramide, the chance of developing TD depends on the dose and the time the patient took the medicine. It is known that TD occurs after using any of these drugs for just six weeks.