What Is a Tissue Plasminogen Activator?

Tissue-type plasminogen activator; tissue-type plasminngen ac: i} ator; t-PA is also called tissue-type plasminogen activator. Natural products are single-chain molecules, containing 527 amino acid glycoproteins.

Tissue plasminogen activator

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Tissue-type plasminogen activator; tissue-type plasminngen ac: i} ator; t-PA is also called tissue-type plasminogen activator. Natural products are single-chain molecules, containing 527 amino acid glycoproteins.

It is catalyzed by plasmin or trypsin to hydrolyze ilrgz-II-Ilcz, r, which is transformed into a double-stranded chain connected by a single disulfide bond. ) 'Light chain has high homology with serine egg autoenzymes such as trypsin, and contains t-Pit's active centers His3az, Asp3o, Serd, and R-t-PA, which are present in many tissues and fluids of the body to dissolve fibrin Serine protein (hydrolase) enzyme. It can selectively and efficiently activate plasminogen in the thrombus to plasmin, which hydrolyzes fibrin in the blood gun. I-PA is mainly extracted from human melanoma cell culture. The products are single-stranded and double-stranded. The former molecular weight is 67 UUU --F} # 3 OUU, and the latter two strands are 3p OOD and 4U UDD} t- The gene of PA. Cheng and egg quality_The goal of Belly is to produce high-efficiency medicine Chuan t-Yr}. Jie_Medicine PA can effectively prevent and treat thrombotic diseases such as acute myocardial infarction.

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