What Is Acetaminophen Liver Damage?
Paracetamol, also known as Tylenol, Panadol, Bufferin, Paracetamol. This product is a metabolite of phenacetin, which regulates central prostaglandin synthase by inhibiting hypothalamic body temperature. Reduce the synthesis and release of prostaglandin PGE1, bradykinin and histamine. PGE1 mainly acts on the nerve center, and its decrease will lead to a decrease in the central body temperature setting point, and the body surface temperature sensor will feel relatively hot, and then cause peripheral blood vessels to dilate and sweat through neuromodulation to achieve antipyretic effect, which inhibits the central nervous system The effect of prostaglandin synthesis is similar to aspirin, but the anti-inflammatory effect is weak. It has no effect on platelets and coagulation mechanisms.
Basic Information
- Chinese name
- Acetaminophen
- Foreign name
- Paracetamol (Acetaminophen)
- Melting point
- 168-172
- Density
- 1,293 g / cm3
- Molecular weight
- 151.16
- CAS number
- 103-90-2
- Related categories
- APIs; Western medicines and APIs; Aromatics
Paracetamol indications
- For cold fever, joint pain, neuralgia and migraine, cancerous pain and postoperative pain relief. This product can also be used for patients who are allergic to aspirin, intolerant or unsuitable for aspirin (varicella, hemophilia, and other bleeding disorders).
Clinical application of paracetamol
- Oral
- 0.3-0.6g once, 0.6-0.8g daily, the daily dose should not exceed 2g, and the course of treatment should not exceed 10 days; children under 12 years old should be divided into 1.5g / m2 daily.
- 2. Intramuscular injection
- 0.15-0.25g once.
- 3. Rectal administration
- 0.3 ~ 0.6g once, 1-2 times daily.
Paracetamol adverse reactions
- A few cases can occur allergic dermatitis (rash, skin itching, etc.), agranulocytosis, thrombocytopenia, methemoglobinemia, anemia, and liver and kidney damage.
Paracetamol precautions
- Short-term use generally does not cause gastrointestinal bleeding. For antipyretic use for no more than 3 days and for pain relief for no more than 5 days. Excessive doses can cause liver damage, and severe cases can cause coma and even death. Do not drink alcohol or alcoholic beverages while taking it.
Contraindications to paracetamol
- Those who are allergic to this product are prohibited. Patients with liver and kidney dysfunction should be used with caution. Use with caution in pregnant and lactating women.
Paracetamol drug interactions
- 1. Because it can reduce the synthesis of coagulation factors in the liver, it has the effect of enhancing anticoagulants. When using it for a long time or in large quantities, pay attention to adjusting the dosage according to the prothrombin time.
- 2. Combined with zifudine, aspirin or other NSAIDs, significantly increase renal toxicity.
- Note: The above content is only for introduction, the drug use must be carried out by a regular hospital under the guidance of a doctor.