What Is Alendronate Sodium?

This product is a white crystalline, non-hygroscopic powder, slightly soluble in ethanol and almost insoluble in chloroform.

Alendronate

This product is a white crystalline, non-hygroscopic powder, slightly soluble in ethanol and almost insoluble in chloroform.

Drug Name

Alendronate

Alias

This product is a third-generation aminobisphosphonate-type bone resorption inhibitor. It has a strong affinity with hydroxyapatite in bone and exerts anti-bone resorption by inhibiting the activity of osteoclasts. Its anti-bone resorption effect is 1000 times stronger than that of etidronate, and it has no inhibitory effect on bone mineralization. Bone mass increased in 96% of patients treated with this product, and vertebral distortion, shortened height, and incidence of fractures (including medulla, spine, and carpal) were improved in postmenopausal women with osteoporosis.

After oral administration, it is mainly absorbed in the small intestine with poor absorption. Food and minerals can significantly reduce their absorption. The plasma protein binding rate of this product is about 80%, the serum half-life is short, and about 20% to 60% of the absorbed drug is quickly taken up by bone tissue. The peak time in bone is about 2 hours after medication, and the rest is quickly passed through the kidney in its original shape Excretion is eliminated. Within 24 hours after taking the drug, more than 99% of the drug stored in the body is concentrated in bone tissue, and the half-life in the bone is about 10 years or more.

It is mainly used for osteoporosis in postmenopausal women.

The recommended dose is 10 mg once daily. Take at least 200 mL of warm water 30 minutes before breakfast. Do not chew or suck pills. It is not advisable to drink milk, dairy products, beverages with high calcium content, orange juice and coffee within 30 minutes before and after taking the medicine. To avoid irritating the esophagus, do not lie down for 30 minutes after taking the medicine.

1. This product is well tolerated, and a few patients can see gastrointestinal reactions, such as nausea, bloating, abdominal pain, occasional headaches, skeletal muscle pain, rare rash or erythema. After the market, side effects such as esophagitis, esophageal erosion and esophageal ulcers occur.

2. Calcium and mineral metabolism disorders, vitamin D deficiency and hypocalcemia must be cured before treatment.

3. Use with caution in patients with gastrointestinal dysfunction, gastritis, duodenitis, and ulcer disease.

4. Not suitable for pregnant and nursing women and children. The safety and effectiveness of osteoporosis medications for men have not been verified and are not recommended.

5. Esophageal abnormalities that cause delayed esophageal emptying. Patients who are allergic to bisphosphonates or hypocalcemia are contraindicated.

6. If you take calcium supplements, antacids and other oral medicines at the same time, it may interfere with the absorption of Fushanmei. After taking this product, patients must wait at least half an hour before taking other drugs.

Tablet: 10 mg. ^[1]