What Is Amoxicillin and Clavulanate?

Amoxicillin potassium clavulanate is suitable for -lactamase producing Haemophilus influenzae and Moraxella catarrhalis lower respiratory tract infections, otitis media, and sinusitis; -lactamase producing Staphylococcus aureus and enzyme-producing intestines Bacillus bacteria such as Escherichia coli, Klebsiella urinary tract and skin soft tissue infections, etc .; can also be used for mild to moderate infections caused by Enterococcus. This product can also be used for the above-mentioned various infections caused by non-enzyme-producing strains in the above bacteria. This product is white or off-white suspended particles, which is aromatic and sweet. This product is a compound preparation, and its components are amoxicillin and potassium clavulanate.

Amoxicillin clavulanate potassium

Potassium amoxicillin clavulanate is suitable for production

Anti-infectives-Other -lactams and -lactamase inhibition

This product is suitable for various infections caused by sensitive bacteria, such as: 1. Upper respiratory tract infection:

"Battle of Resistance"

This product is stable to gastric acid, good oral absorption, and food has no significant effect on the absorption of this product. 375 mg (250 mg amoxicillin and 125 mg clavulanic acid) is administered orally on an empty stomach. Amoxicillin reaches a peak plasma concentration (Cmax) of about 5.6 mg / L in 1.5 hours. The blood elimination half-life (t1 / 2) is about 1 hour. The 8-hour urine excretion rate is 50% to 78%. The pharmacokinetic parameters of clavulanic acid are the same as when used alone. Normal people reach a peak plasma concentration (Cmax) of about 1 mg / L after 125 mg of oral clavulanic acid, which is about 3.4 mg / L. The protein binding rate is 22% to 30%. The blood elimination half-life (t1 / 2) is 0.76 to 1.4 hours, and the urine excretion rate at 8 hours is about 46%. Oral bioavailability was 97% and 75%, respectively.

This product is a compound preparation composed of amoxicillin and potassium clavulanate in a 7: 1 ratio.

1 Aspirin, indomethacin, butazone, and sulfa drugs can reduce the excretion of this product in the renal tubules, thus increasing the blood concentration of this product, prolonging the blood elimination half-life (t1 / 2 (), and the toxicity may also increase .

2 When this product is combined with allopurinol, the incidence of rash is significantly increased, so it should be avoided.

3 This product should not be combined with acetaldehyde dehydrogenase inhibitors such as disulfiram.

4 This product is used in combination with chloramphenicol for bacterial

See amoxicillin sodium. Children under 40kg should not use tablets, but should use suspensions. The clavulanic acid content in the 375mg and 625mg tablets are both 125mg, so the latter 1 tablet is not equal to the former 2 tablets.

This product does not affect absorption when taken orally. Taking it with food can reduce gastrointestinal reactions.

In patients with renal insufficiency, when the serum creatinine clearance rate is 10 to 30 ml / min and 2 to 9 ml / min, the dosing interval should be adjusted to once every 12 hours and 24 hours. ^[3]

Adult:

1. Amoxicillin and potassium clavulanate tablets: 375mg (250mg amoxicillin, 125mg clavulanate); 625mg (500mg amoxicillin, 125mg clavulanate). It should be noted that two 375mg preparations cannot be used instead of 625mg preparations.

2. Amoxicillin and clavulanate potassium suspension: 5ml: 156.25mg (amoxicillin 125mg, clavulanic acid 31.25mg); 5ml: 312.5mg (amoxicillin 250mg, clavulanic acid 62.5mg). ^[3]

This product is suitable for enzyme-producing Haemophilus influenzae and

Banned in those who are allergic to this product, those who have a history of allergies to penicillin, or those who have a history of allergies to clavulanic acid. ^[3]

1. Common gastrointestinal reactions such as diarrhea, nausea and vomiting.

2. Rash, especially prone to infectious mononucleosis.

3. Visible anaphylactic shock, drug fever and asthma.

4. Occasionally elevated serum transaminase, increased eosinophils, decreased white blood cells, and double infection caused by Candida or drug-resistant bacteria.

1.Persons who are allergic to cephalosporins and have asthma, eczema, hay fever,

Drug Name

Common name: Amoxicillin sodium clavulanate potassium tablets ^[4]

Product Name: Amoxicillin and Clavulanate Potassium Tablets (Jin Lishu)

English name: Amoxicillin and Clavulanate Potassium Tablets

Full Pinyin: AMoXiLinKeLaWeiSuanJiaPian (JinLiShu)

[Main ingredients] Amoxicillin, potassium clavulanate.

[Ingredients]

Molecular formula: C16H19N3O5S · 3H2O

Molecular weight: 419.46

[Character]

This product is a film-coated tablet. It is white or pale yellow after removing the coating.

[Introduction / Commodity effect] This product is suitable for various infections caused by sensitive bacteria, such as: 1. Upper respiratory tract infections: sinusitis, tonsillitis, pharyngitis, etc. 2. Lower respiratory tract infections: acute bronchitis, acute exacerbation of chronic bronchitis, pneumonia, lung abscess, and concurrent bronchial infection. 3. Urinary system infection: cystitis, urethritis, pyelonephritis, prostatitis, pelvic inflammatory disease, Neisseria gonorrhoeae urinary tract infection and soft chancre. 4. Skin and soft tissue infections: scabies, abscesses, cellulitis, wound infections, intra-abdominal sepsis, etc. 5. Other infections: otitis media, osteomyelitis, sepsis, peritonitis, and postoperative infections.

[Specifications] 0.457g * 6s

[Usage and Dosage] Oral. 1 tablet for adults and children over 12 years old, 3 times a day. The dose can be doubled in severe infections. Without re-examination, the continuous treatment period does not exceed 14 days.

[Adverse reaction] ^[5]

1. Common gastrointestinal reactions such as diarrhea, nausea and vomiting.

2. Rash, especially prone to infectious mononucleosis.

3. Visible anaphylactic shock, drug fever and asthma.

4. Occasionally elevated serum aminotransferase, increased eosinophils, decreased white blood cells, and double infection caused by Candida or drug-resistant bacteria.

Contraindications

Penicillin skin test positive responders, allergic to this product and other penicillin drugs and patients with infectious mononucleosis are contraindicated.

Precautions

1. Each patient must take a penicillin skin test before starting to use this product.

2. Patients who are allergic to cephalosporins and those who have a history of allergic diseases such as asthma, eczema, hay fever, urticaria and severe liver dysfunction should be used with caution.

3. This product has cross-allergy with other penicillins and cephalosporins. If an allergic reaction occurs, this product should be discontinued immediately and appropriate measures taken.

4. This product has complete cross-resistance with ampicillin and cross-resistance with other penicillins and cephalosporins.

5. For patients with gonorrhea suspected to be associated with syphilis damage, a dark field examination should be performed before using this product, and a serum test should be performed once a month for at least 4 months.

6. For patients with gonorrhea suspected to have syphilis damage, a dark field examination should be performed before using this product, and a serum test should be performed at least once every 4 months.

7. Patients with severe liver dysfunction should be used with caution. Long-term or large doses of this product should be regularly checked for liver, kidney, hematopoietic system function and serum potassium or sodium.

8. Interference to laboratory inspection indicators: (1) The copper sulfate method urine test can be false positive, but the glucose enzyme test method is not affected; (2) can make serum alanine aminotransferase or aspartate Aminotransferase measurements increased.

[Children's medication] is not clear.

[Medication for elderly patients]

Elderly patients should adjust the dosage or interval according to renal function.

[Medication for pregnant women and lactating women] 1. This product can pass through the placenta, and the concentration of umbilical cord blood is 1/4 to 1/3 of the maternal blood concentration, so it is prohibited for pregnant women. 2. This product can be secreted into breast milk, which may cause sensitization of infants and cause diarrhea, rash, infection of Candida, etc. Therefore, breastfeeding women should be used with caution or the breastfeeding should be suspended during medication.

medicine interactions

1. Aspirin, indomethacin, butasone, and sulfa drugs can reduce the excretion of this product in the renal tubules, thus increasing the blood concentration of this product, prolonging the blood elimination half-life (t1 / 2), and increasing the toxicity .

2. When this product is combined with allopurinol, the incidence of rash is significantly increased, so it should be avoided.

3. This product should not be used in combination with acetaldehyde dehydrogenase inhibitors such as disulfiram.

4. When this product is used in combination with chloramphenicol for bacterial meningitis, the incidence of long-term sequelae is higher than when they are used alone.

5. This product can stimulate estrogen metabolism or reduce its enterohepatic circulation, so it can reduce the effect of oral contraceptives.

6. Antibiotics such as chloramphenicol, erythromycin, tetracycline, and bacteriostatic drugs such as sulfa drugs can interfere with the bactericidal activity of this product, and should not be used in combination with this product, especially when treating meningitis or severe infections in need of bactericides.

7. This product can strengthen the role of warfarin.

8. Aminoglycoside antibiotics can generally enhance the in vitro bactericidal effect of this product on Enterococcus faecalis at subinhibitory concentrations.

9. Since the absorption of this product in the gastrointestinal tract is not affected by food, it can be taken on an empty stomach or after a meal, and can be taken with food such as milk; taking with food can reduce gastrointestinal reactions.

[Drug overdose] is unclear.

[Pharmacology and Toxicology]

still uncertain

Pharmacokinetics

still uncertain

[Storage] Sealed, stored in a cool and dry place

[Packing] 6 pieces per box, 1 plate per bag, 1 bag per small box.

[Validity] 24 months

[Executive Standards] Chinese Pharmacopoeia 2010 Edition Two

[Approval number] National Medicine Standard H20041114

[Manufacturer] Guangzhou Baiyunshan Pharmaceutical Co., Ltd. Guangzhou Baiyunshan Pharmaceutical General Factory