What Is Crotamiton?

Crotamiton chemical name is N-ethyl-N- (2-methylphenyl) -2-butenamide, colorless to light yellow oily liquid; slight odor; can be part or all at low temperature Curing. This product is very soluble in ethanol or ether, slightly soluble in water. The molecular formula is C ₁₃ H ₁₇ NO, the molecular weight is 203.28000, the density is 0.987 g / mL at 25 ° C (lit.), And the boiling point is 153-155 ° C ₁₃ mm Hg (lit.).

Chinese name: Cromiton
Foreign name: crotamiton

CAS number: 483-63-6
Molecular formula: C13H17NO

Cromiton compounds

Cromtone Basic Information

Chinese name

Chinese alias: N-ethyl-o-crotonylmethylaniline; Youlifu;

English name: crotamiton

English alias: N-ethylcrotono-o-toluidide; N-Ethyl-o-Crotonotoluidine (Crotamiton); N-Ethyl-o-crotonotoluidide, Crotamiton; N-Ethyl-o-crotonotoluidide; Crotamiton

CAS number: 483-63-6

Molecular formula: C ₁₃ H ₁₇ NO

Chemical structure:

Molecular weight: 203.28000

Exact mass: 203.13100

PSA: 20.31000

LogP: 2.92400 ^[1]

Cromiton physical and chemical properties

Density: 0.987 g / mL at 25 ° C (lit.)

Boiling point: 153-155 ° C13 mm Hg (lit.)

Flash point:> 230 ° F

Refractive index:

= 1.54 (lit.)

Stability: Stable at normal temperatures and pressures.

Storage conditions: Keep tightly closed.

Vapor pressure: 0.00331mmHg at 25 ° C ^[1]

Cromiton molecular structure data

1. Molar refractive index: 642.01

2. Molar volume (m / mol): 00.4

3. Isotonic specific volume (90.2K): 4938.3

4. Surface tension (dyne / cm): 8.1

5. Polarizability (10cm): 25.37 ^[2]

Cromiton production method

No ^[1]

Cromiton uses

Anti scabies medicine, used to treat scabies and itching skin. ^[1]

Clomitone Pharmacopoeia Standard

Cromiton source (name), content (potency)

This product is a mixture of cis and trans isomers of N-ethyl-N- (2-methylphenyl) -2-butenamide. Containing C13H17NO should be 98.0% to 102.0%. ^[3]

Cromiton traits

This product is a colorless to pale yellow oily liquid; slightly odorous; it can be partially or fully cured at low temperatures.

This product is very soluble in ethanol or ether, slightly soluble in water.

Relative density

The relative density of this product is 1.008 1.011.

Refractive index

The refractive index of this product is 1.540 1.542. ^[3]

Cromiton identification

(1) Take about 10ml of this product's saturated aqueous solution, add a few drops of potassium permanganate test solution, it will become brown, and a brown precipitate will form after standing.

(2) In the chromatogram recorded under the content determination item, the retention time of the main peak of the test solution should be consistent with the retention time of the main peak of the reference solution.

(3) Take this product, add cyclohexane to make a solution containing about 10g per 1ml, and measure it according to ultraviolet-visible spectrophotometry. It has maximum absorption at a wavelength of 242nm. ^[3]

Cromiton inspection

Cis isomer

If there is a cis isomer peak in the chromatogram of the test solution under the content determination item, its peak area must not exceed 15% of the sum of the cis and trans isomer peak areas.

relative substance

Take an appropriate amount of this product, accurately weigh it, add mobile phase to dissolve and dilute it to make a solution containing about 0.5mg per 1ml as the test solution; precisely measure 1ml of the test solution, place it in a 100ml measuring bottle, and use the flow The phases were diluted to the mark and shaken as a control solution. According to the chromatographic conditions under the content determination item, take 20 l of the control solution and inject it into the liquid chromatograph to adjust the detection sensitivity so that the peak height of the clomitone trans isomer peak is about 30% of full scale; Take 20 l each of the test solution and the control solution, and inject them into the liquid chromatograph respectively, and record the chromatogram to 2.5 times the retention time of clomitone trans isomer. If there is an impurity peak in the chromatogram of the test solution, the peak area of N-ethyl-N- (2-tolyl) -3-butenamide (impurity ) with a relative retention time of 0.7 to 0.8 must not be larger than the control 0.75 times (0.75%) the sum of the cis and trans isomer peak areas in the solution; except for the cis isomer and impurity , the sum of the peak areas of other impurities must not be greater than the cis and trans isomer peaks in the control solution Total area (1.0%). Any peak in the test solution that is smaller than the sum of the cis and trans isomer peak areas in the control solution by 0.02 times is negligible.

chloride

Take 1.0g of this product, add 25ml of ethanol and 5ml of 20% sodium hydroxide solution, heat to reflux for 1 hour, let cool, transfer to a separatory funnel, add 25ml of ether and 10ml of water, shake, and stand to separate the layers. Take the water layer and place it in a 50ml Nessler colorimetric tube, add water to make 25ml, add 5ml of nitric acid and water to make 50ml, add 1.0ml of silver nitrate test solution, shake well, and check according to law; with standard sodium chloride solution 10.0ml, Add 5ml of 20% sodium hydroxide solution to 25ml with an appropriate amount of water. From "add 5ml of nitric acid", compare with the control solution made by the same method, it must not be more concentrated (0.01%).

Free amine

Take 5.0g of this product, add 70ml of ether to dissolve, and extract twice with 10ml dilute hydrochloric acid. Combine the extracts, wash with ether twice, 50ml each time, separate the acidic extract, and evaporate on a water bath to Dry, dry to constant weight at 105 ° C, and the residue should not exceed 2.5mg.

Residue on ignition

Must not exceed 0.1%. ^[3]

Clomiton determination

As determined by high performance liquid chromatography.

Chromatographic conditions and system suitability tests

Silica gel was used as a filler; cyclohexane-tetrahydrofuran (92: 8) was used as a mobile phase, and the detection wavelength was 242 nm. The relative retention time of the clomiton cis isomer peak is between 0.5 and 0.6. The theoretical number of plates is calculated to be not less than 5000 based on the clomiton trans isomer peak. The clomiton trans isomer peak Resolution from the clomitone cis isomer peak should be greater than 8.0.

Assay

Take about 50mg of this product, accurately weigh, place in a 100ml measuring bottle, add mobile phase to dissolve and dilute to the mark, shake well, and take 5ml precisely, place in a 100ml measuring bottle, dilute to the mark with mobile phase, shake well, precision Measure 20 l, inject it into a liquid chromatograph, and record the chromatogram; take another clomiton reference and measure it in the same way. According to the external standard method, the sum of peak areas of clomitone cis and trans isomers can be calculated. ^[3]

Clomidone chemical related drugs

Clomitone drug name:

[Common name] Cromiton cream

[English name] Crotamiton Cream

[Chinese Pinyin] Ke Luo Mi Tong Ru Gao ^[4]

Cromiton Ingredients:

The main ingredient of this product is clomitone, whose chemical name is: a mixture of cis and trans isomers of N-ethyl-N- (2-methylphenyl) -2-butenamide. ^[4]

Cromiton category:

Chemical Drugs and Biological Products >> Dermatological Drugs >> Anti-Infectives for Skin >> Anti-parasites for Skin ^[4]

Cromiton traits:

This product is a white cream. ^[4]

Cromiton effect category:

This product is a non-prescription drug for dermatology. ^[4]

Cromiton indications:

For the treatment of scabies and pruritus. ^[4]

Cromitone specifications:

10 grams: 1 gram; 20 grams: 2 grams ^[4]

Clomi universal dosage:

1. For scabies, take a bath and wipe dry before treatment. Apply this product to the entire skin from below the neck, especially the creases, hands, feet, between your toes, underarms, and groin. After 48 hours, take a bath to wash off the medication, put on clean clothes, and change the sheets; the spouse and the patients at home should be treated at the same time. Can be repeated once a week.
2. When used for itching, apply it topically to the affected area 3 times a day. ^[4]

Cromiton adverse reactions:

Can cause contact dermatitis with occasional allergic reactions. ^[4]

Cromiton contraindications:

Acute inflammatory, erosive or exudative lesions are contraindicated. ^[4]

Cromiton note:

1. Those who are allergic to this product are prohibited.
2. Can not be used on a large area of the skin of infants and young children.
3. Avoid contact with eyes and other mucous membranes (such as mouth, nose, etc.).
4. Disable when the character of this product changes.
5. Children must use under adult supervision.
6. Keep this medicine out of the reach of children. ^[4]

Clomidone drug interactions:

Drug interactions may occur if used concurrently with other drugs, please consult your physician or pharmacist for details. ^[4]

Clomiton pharmacological effects:

This product acts on the nervous system of roundworms, paralyzing roundworms and dying. In addition, there is still a slight local anesthesia effect to relieve itching. ^[4]

Cromiton Expert Reviews

The mechanism of killing chigger mites by this product is not clear, and it is mainly used for scabies in clinic. This product is second only to Lin Dan's medicine for treating scabies, and has a better effect than sulfur ointment. It has the advantage of not contaminating the clothes and being applicable to children over 4-5 years old. The treatment of anal itching is also outstanding. According to domestic reports, the Chinese Academy of Medical Sciences applied this product to treat 363 cases of scabies and recovered 270 cases, of which 60 cases were markedly effective, 22 cases were effective, and 11 cases were ineffective. Another 297 cases of pruritus dermatosis were treated with this drug in the Affiliated Hospital of Yangzhou Medical College, 160 cases were cured, 75 cases were markedly effective, 42 cases were improved, and 20 cases were ineffective. ^[5]