What Is Cyproheptadine HCl?
Glaucoma, enlarged prostate, urinary retention, and pyloric obstruction are contraindicated. Use with caution in patients with hyperthyroidism, bronchial asthma, hypertension, gastric ulcers, and the elderly. Can affect driving and mechanical operation capabilities. Do not use in combination with central nervous system inhibitors, anticholinergics, alcohol, and monoamine oxidase inhibitors.
Cyproheptadine hydrochloride
- [Raw material name] Cyproheptadine hydrochloride (2012 National Essential Medicine)
- CAS: 41354-29-4
- Molecular formula: C21H21N · HCl
- Molecular weight: 323.86
- [Drug name]
- S26In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
- After accidental contact with eyes, rinse immediately with plenty of water and seek medical advice.
- S36Wear suitable protective clothing.
- Wear appropriate protective clothing. [1]
- R22Harmful if swallowed.
- Harmful if swallowed.
- R36 / 37 / 38Irritating to eyes, respiratory system and skin.
- Irritation of eyes, respiratory system and skin.
- Melting point: 165 ° C (dec.) (Lit.) [1]
- medicine analysis
- Method name: Determination of Cyproheptadine Hydrochloride-Neutralization Titration
- Application range: This method uses titration to determine the content of cyproheptadine hydrochloride.
- This method is applicable to cyproheptadine hydrochloride.
- Principle of the method: After adding glacial acetic acid to the solution for dissolution and cooling, add the mercury acetate test solution and crystal violet indicator solution, and titrate with the perchloric acid titration solution (0.1mol / L) until the solution becomes blue, and record the perchloric acid. The amount of titrant used is calculated.
- Reagent: 1. Water (new boiling to room temperature)
- 2. Perchloric acid titrant (0.1mol / L)
- 3. Crystal violet indicator liquid
- Acetic anhydride
- 5. Glacial acetic acid
- 6. Mercury acetate test solution
- 7. Reference Potassium Phthalate
- Sample preparation: 1. Perchloric acid titration solution (0.1mol / L)
- Preparation: Take 750mL of anhydrous glacial acetic acid (calculated with water content, add 5.22mL acetic anhydride per 1g of water), add 8.5mL perchloric acid (70% -72%), shake well, and slowly add acetic anhydride dropwise at room temperature. 23mL, shake while adding, shake evenly after adding, let cool, add an appropriate amount of anhydrous glacial acetic acid to 1000mL, shake well, and leave for 24 hours. If the test sample is easily acetylated, the water content on this page must be determined by moisture measurement, and then the water content of this solution should be adjusted to 0.01% -0.2% with water and acetic anhydride.
- Calibration: Take about 0.16g of standard potassium hydrogen phthalate dried to constant weight at 105 , accurately weigh, add 20mL of anhydrous glacial acetic acid to dissolve, add 1 drop of crystal violet indicator solution, and titrate slowly with Blue, and the results of the titration are corrected with a blank test. Each 1mL of perchloric acid titration solution (0.1mol / L) is equivalent to 20.42mg of potassium hydrogen phthalate. Calculate the concentration of this solution based on the consumption of this solution and the amount of potassium hydrogen phthalate taken.
- Storage: Place in a brown glass bottle and keep tightly closed.
- Crystal violet indicator liquid
- Take 0.5g of crystal violet, add 100mL of glacial acetic acid to dissolve, and get.
- Operation steps: Accurately weigh 0.3 g of the test product, add 10 mL of glacial acetic acid to dissolve, add 5 mL of mercury acetate test solution and 1 drop of crystal violet indicator solution, and titrate the solution with perchloric acid titration solution (0.1 mol / L) Blue, and the results of the titration were corrected with a blank test. The volume of perchloric acid titrant (mL) was recorded. Each 1 mL of perchloric acid titrant (0.1 mol / L) was equivalent to 32.39 mg of cyproheptadine hydrochloride ( C21H21N · HCl · 3 / 2H2O).
- Note 1: "Precision weighing" means that the weighed weight should be accurate to one thousandth of the weight. Precision requirements.
- References: Pharmacopoeia of the People's Republic of China, compiled by the National Pharmacopoeia Committee, Chemical Industry Press, 2005 edition, Part Two, p.589.
- Latest use
- 1. Treatment of anorexia in children; 2. Bronchial asthma; 3. Asthmatic bronchitis in children; 4. Amenorrhea-lactation syndrome; 5. Dump syndrome; 6. Treatment of migraine; 7. Hepatic pruritus; 8. Inner ear dizziness
- [Packing specifications] 10 kg / barrel; 25 kg / barrel
- Substances prohibited in feed and animal drinking water
- Announcement No. 1519 of the Ministry of Agriculture on December 27, 2010 lists substances banned from use in feed and animal drinking water.