What Is Diethylstilbestrol?

Diethylstilbestrol is a synthetic non-steroidal estrogen that can produce all the pharmacological and therapeutic effects of natural estradiol. It is mainly used for functional bleeding and amenorrhea caused by estrogen hypoxia and hormonal imbalance. It can also be used before stillbirth to induce labor to improve the sensitivity of uterine muscle to oxytocin.

Drug Name: Diethylstilbestrol

Drug aliases: Diethylstilbestrol propionate,

With phenol as the starting material, polyphosphoric acid (PPA) as the catalyst, and p-hydroxyphenylacetone were prepared by reaction of n-propionic acid with Firedd, C-Crafts.JM, and then reacted with acetic anhydride to protect the phenolic hydroxyl esterification Then, a coupling is reduced with TiCl4 / Zn in a tetrahydrofuran solution, and then hydrolyzed with potassium hydroxide to remove acetate and finally acidified with hydrochloric acid to obtain a product. ^[4]

(1) Take about 10mg of this product, add 1ml of sulfuric acid to dissolve, the solution is orange-yellow (hexaneestrol is light yellow); after adding 10ml of water to dilute, the color will disappear.

(2) Recorded under the content determination item

Hexene

Diethylstilbestrol safety term

S36 / 37 / 39Wear suitable protective clothing, gloves and eye / face protection.

Wear appropriate protective clothing, gloves and goggles or masks.

S45In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.)

In case of accident or if you feel unwell, seek medical advice immediately (show the label if possible).

S53Avoid exposure-obtain special instructions before use.

Avoid contact. Obtain special instructions before use.

S60This material and its container must be disposed of as hazardous waste.

The substance and its container must be disposed of as hazardous waste.

S61Avoid release to the environment. Refer to special instructions / safety data sheets.

Avoid release to the environment. Refer to special instructions / safety data sheet. ^[3]

Diethylstilbestrol risk term

R40 Limited evidence of a carcinogenic effect.

A few reports have carcinogenic consequences.

R45May cause cancer.

May cause cancer.

R61May cause harm to the unborn child.

May cause harm to the fetus.

R36 / 37 / 38Irritating to eyes, respiratory system and skin.

Irritation of eyes, respiratory system and skin.

R51 / 53 Toxic to aquatic organisms, may cause long-term adverse effects in the aquatic environment.

Toxic to aquatic organisms, may have long-term adverse effects on the aquatic environment. ^[4]