What Is Fluoroquinolone Resistance?

Fluoroquinolones belong to quinolones, also known as picolinones, which are chemically synthesized antibacterials. Clinically used to treat urinary tract, intestinal tract, respiratory tract, skin and soft tissue, abdominal cavity, bone and joint infections, etc., with good results.

Fluoroquinolone

Fluoroquinolones are quinolones, also known as

Broad antibacterial spectrum and strong antibacterial activity, especially against G-bacteria

Among the more widely used varieties of fluoroquinolones, ciprofloxacin has a stronger effect on Pseudomonas aeruginosa, with a MIC90 of 1 mg.L-1, followed by a fluoxazine MIC90 of 2 mg.L-1. Although Haloperic acid is resistant to Pseudomonas aeruginosa MIC90 at 2 mg.L-1, it has poor absorption, low blood concentration, and cannot effectively control infection. Therefore, ciprofloxacin is a better application variety. The effect of fluoxacin on general negative bacteria is similar to or slightly weaker than that of ciprofloxacin. Some new varieties of polyfloxacin developed after the 1990s have similar anti-G-bacteria activity to ciprofloxacin. Moreover, the anti-G + cocci effect is strengthened, it is effective for MRSA, and it also has a certain effect on chlamydia, mycoplasma and anaerobic bacteria, which is obviously better than ciprofloxacin. According to foreign reports, such drugs have broken through the concept of antibacterial, and also made new progress in antiviral and antitumor, and have made remarkable achievements. It is expected that from the end of this century to the beginning of the next century, there will be more promising new varieties of this class of drugs.

With the widespread use of fluoroquinolones, bacterial resistance and adverse reactions have also occurred. Newly listed fluoroquinolones such as Temafloxacin were listed in the UK in 1992 only 15

1 Dai Ziying, editor. Practical Antibacterial Pharmacology. First edition. Shanghai: Science and Technology Press, 1992, 268 276

2 Chen Xinqian, Chief Editor Jin Youyu. New edition of Pharmacology. Thirteenth Edition. Beijing: People's Medical Publishing House, 1994, 101-103

3 Zhang Zhiping. Chinese Journal of Antibiotics, 1992, 17 (2): 87

4 Chen Huating, Zhang Yu, Chen Wei et al. 1995 Evaluation of Quinolones in Wuhan Region. China Pharmacy, 1997, 8 (3): 116

5 Fan Yong, Yang Guoqin. Analysis of the use of quinolones in Nanjing in 1996. China Pharmacy, 1997, 8 (6): 268

6 Edited by Li Jiatai. Clinical Pharmacology. First edition. Beijing: People's Medical Publishing House, 1991, 511 518

7 Sun Manqin. Safety evaluation of quinolone antibacterials. Proceedings of the National Symposium on Clinical Evaluation of Anti-Infective Drugs. Expert Committee on Clinical Drug Evaluation of the Chinese Medical Association. Beijing, 1996, 67