What Is Imipenem?

Imipenem is a medical drug that is mainly used clinically for respiratory infections, biliary infections, urinary and abdominal infections, skin and soft tissues, bones and joints, gynecological infections caused by gram-positive bacteria, negative bacteria, anaerobic bacteria. .

Chinese name: Imipenem
Foreign name: Imipenem

Application: Gram-positive bacteria, negative bacteria, etc.
nickname: Imithiomycin; Taineng, etc.

Imipenem Basic Information

Chinese name: Imipenem

Chinese alias: (5R, 6S) -6-[(1R) -1-hydroxyethyl] -3-[[2-[(iminomethyl) amino] ethyl] thio] -7-oxo- 1-azabicyclo [3.2.0] hept-2-ene-2-carboxylic acid; imithiomycin; Taineng

English name: Imipenem

English alias: (5R, 6S) -6-[(1R) -1-hydroxyethyl] -3-[[2-[(iminomethyl) amino] ethyl] thio] -7-oxo-1-azabicyclo [3.2.0] hept-2-ene-2-carboxylic acid; [5R- [5alpha, 6alpha (R *)]]-6- (1-Hydroxyethyl) -3- [[2-[(iminomethyl) amino] ethyl] thio]- 7-oxo-1-azabicyclo [3.2.0] hept-2-ene-2-carboxylic acid; (5R, 6S) -3-[(2-{[((E) -aminomethylidene] amino} ethyl) sulfanyl]- 6-[(1S) -1-hydroxyethyl] -7-oxo-1-azabicyclo [3.2.0] hept-2-ene-2-carboxylic acid; (5R, 6S) -3-[(2-{[( E) -aminomethylidene] amino} ethyl) sulfanyl] -6-[(1R) -1-hydroxyethyl] -7-oxo-1-azabicyclo [3.2.0] hept-2-ene-2-carboxylic acid

CAS number: 64221-86-9

Structural formula

EINECS number: 264-734-5

Molecular formula: C12H17N3O4S · H2O

Molecular weight: 317.36

Storage: sealed, shading, stored at 2 8 .

Category: -lactam antibiotics

Imipenem action uses

Imipenem has antibacterial effects on Gram-positive, negative aerobic and anaerobic bacteria. The antibacterial spectrum includes Streptococcus, Staphylococcus aureus, Escherichia coli, Klebsiella, some strains of Acinetobacter, Haemophilus influenzae, Proteus serratia, Pseudomonas aeruginosa, and the like.

Clinically, it is mainly used for respiratory infections caused by gram-positive bacteria, negative bacteria, anaerobic bacteria, biliary tract infections, urinary system and abdominal cavity infections, skin and soft tissues, bones and joints, and gynecological infections.

Imipenem indications

It is especially suitable for mixed infections caused by multiple pathogens and aerobic / anaerobic bacteria, and early treatment before pathogens are identified. This product is used for various infections caused by sensitive bacteria, especially suitable for multiple infections and mixed infections of aerobic and anaerobic bacteria, such as peritonitis, hepatobiliary infections, intra-abdominal abscesses, appendicitis, gynecological infections, lower respiratory tract Infections, skin and soft tissue infections, urinary tract infections, bone and joint infections, and sepsis.

Imipenem dosage usage

Intramuscular or intravenous infusion, the dose is based on imipenem. For adults, 1g to 2g / day, divided into 2 to 4 times. Intramuscularly, 1% lidocaine injection can be formulated into a suspension to reduce pain. Intravenous, can be dissolved and diluted with normal saline or 5% glucose, formulated to a concentration of 5mg / ml, slowly intravenously. Children 60mg to 100mg / kg daily, divided into 3 to 4 times.

Imipenem drug action

This product has some cross-allergic reactions with other -lactam antibiotics, penicillins and cephalosporins.

For intramuscular injection, use 1% lidocaine injection as a solvent to reduce pain, but those who are allergic to lidocaine are contraindicated.

Imipenem side effects

1 Allergic reactions such as drug rash, itching, urticaria.

2 Gastrointestinal reactions such as nausea, vomiting, and diarrhea.

3 Side effects on the liver, which can cause elevated alanine aminotransferases.

4 Use with caution for allergies.

Imipenem notes

This product cannot penetrate the blood-brain barrier (BBB), so it is not suitable for meningitis.

Clinical application of imipenem

Imipenem is a thiomycin antibacterial drug with a carbapenem ring. Its antibacterial effect and stability are better than thiamin. It shows good affinity for various bacterial penicillin-binding proteins (PBPs). It has a broad spectrum and strong antibacterial effect, but when used alone, it has poor stability in the body. About 80% of it can be destroyed by renal dehydrogenase 1 (renal coenzyme I, DHP I) produced by the renal cell membrane. Cilastatin is a DHP-I inhibitor. It does not have an antibacterial effect, but it can protect imipenem from damage in the kidney and increase the recovery of its original drug in the urine to 70% -80%. Cilastatin also prevents imipenem from entering human renal tubular epithelial tissue and reduces its renal toxicity. However, it has no effect on other pharmacokinetic processes of imipenem. Clinically, imipenem and cilastatin sodium are used as a compound preparation, such as "imipenem cilastatin sodium for injection".