What is indomethacin?

Indomethacin is a type of drug called non -steroidal anti -inflammatory (NSAID). These drugs treat symptoms such as swelling, stiffness, pain and fever inhibiting molecules called prostaglandins. Indometacin is also called indometacin and is sold under brands such as Indocin & Reg: Indocid® and Indocrhron®.

This drug is used to reduce the symptoms of inflammatory conditions such as osteoarthritis, rheumatoid arthritis, menstrual pain, DNA, tendinitis and bursitis. The primary symptoms of these conditions are generally pain, stiffness and swelling, all of which are the reactions associated with the inflammatory response. In addition, the drug is tocolytic, which means that it can reduce uterine contractions in women who undergo premature work.

Some of the most important molecules involved in the support of the inflammatory answer are prostaglandins. These molecules are produced mostly cell types in response to cell damage. After being produced and excreted by cells, prostaglandins on mast cells,This is a type of immune cell that is central for the development of inflammation. Prostaglandins also affect endothelial cells that line blood vessels and cells in the uterus.

Indomethacin works to suppress inflammation in several ways. The primary mechanism of action is inhibition of prostaglandin synthesis. This is achieved by inhibiting cyclooxygenase, an enzyme that is central to prostaglandin production. In addition, the medicine reduces the mobility of some types of white blood cells, which prevents them from migrating to the site of inflammation and escalating the answer.

This drug has several possible side effects. The most common side effects are headaches, dizziness, dizziness, tinnitus and visual disorders. Other possible effects include high blood pressure, flu flu and elevated levels of potassium and sodium. In very rare cases, side effects such as tachycardia and heavy low blood pressure may occur.

Indomethacin msome contraindications; This means that people with certain conditions cannot use this medicine. For example, people who have a peptic ulcer or a history of peptic ulcers must avoid most NSAIDs. This is because prostaglandins are important in maintaining the health of the gastrointestinal tract and prolonged use of NSAIDs can lead to stomach irritation. In addition, people with kidney or liver damage, bone marrow damage or blood clotting generally cannot take indomethacin. This medicine can also worsen the symptoms of epilepsy, Parkinson's disease and certain disorders of psychosis.

A long list of potential adverse effects means that the use of this drug is limited and instead of newer NSAIDs with fewer side effects are often used. In most cases, this drug is only prescribed for short -term use. For example, women may be prescribed this medicine for menstrual pain because it is safe to take when the use is limited to several days at a time.