What Is Lidocaine Spray?

Lidocaine aerosol is used for local anesthesia of the skin and mucous membranes. It can be used for oral and nasal mucosal surgery, dental extraction surgery, abscessotomy. Catheters, laryngoscopes, and gastroscopes are easy to insert.

Drug Name: Lidocaine aerosol

Drug type: Prescription drugs, topical drugs, medical insurance workers' injuries
Use classification: Antitachycardia

Lidocaine aerosol ingredients

The main ingredient of this product is lidocaine, and its chemical name is N- (2,6-xylyl) -2- (diethylamino) acetamide.
Molecular formula: C ₁₄ H ₂₂ N ₂ 0
Molecular weight: 234.34

Lidocaine Aerosol Properties

This product is a colorless or slightly yellow clear liquid. When the valve is pressed, the medicinal solution is sprayed out as mist, and it has a special smell of mint when sprayed.

Lidocaine Aerosol Indications

This product is suitable for local anesthesia of the skin and mucous membranes. It can be used for oral and nasal mucosa surgery, dental extraction surgery, abscessotomy. Gastroscopy catheters are easy to insert.

Lidocaine Aerosol Specifications

Each bottle has a total weight of 25 grams and contains 1.75 grams of lidocaine.

Lidocaine Aerosol Usage and Dosage

Usage: Remove the cap and shell of this product, insert the nozzle with a catheter, hold the spray bottle vertically, press the nozzle at the administration site as needed, and the liquid particles will spray out. Dosage: Minor surgery on mouth, nasal cavity, and throat, local spray twice, interval of 1-2 minutes, three times each time, 4.5mg each time, total 27mg. Apply 1-2 minutes after spraying. Gastroscopy and laryngoscopy intubation: two sprays at the throat, two intervals between 3 minutes, 4.5 mg each, 18 mg total. Bronchoscopy intubation: two sprays on the throat, two intervals between 1-2 minutes, two strokes each time, 4.5 mg per stroke, total 27 mg. The adult dose of this product should not exceed 100mg (22 ).

Lidocaine aerosol adverse reactions

(1) This product can cause hypersensitivity and allergic reactions;
(2) It can cause bronchospasm in patients with high respiratory sensitivity;
(3) Excessive dose of this product and absorption too quickly can cause toxic reactions, manifested as central nervous excitement symptoms such as tinnitus, agitation, and irritability, and can quickly develop into convulsions, coma, decreased blood pressure, etc .;
(4) Excessive blood concentration can cause slow atrial conduction velocity, atrioventricular block, ventricular fibrillation and cardiac arrest.

Lidocaine aerosol contraindications

Allergic to local anesthetics, porphyria, uncontrolled epilepsy, Alzheimer's syndrome (acute cardiogenic cerebral ischemia syndrome), pre-excitation syndrome, severe cardiac block (including sinoatrial, atrial Ventricular and ventricular block) patients are disabled.

Lidocaine aerosol precautions

(1) Use with caution in patients with liver and kidney dysfunction, reduced liver blood flow, congestive heart failure, severe myocardial damage, hypovolemia, and shock. People with original indoor conduction block should also be used with caution.
(2) The tolerance of this product varies greatly among individuals.
(3) This product is more toxic than proca because it is more prone to spread and strictly control the total amount of medication. Excessive amounts can cause convulsions and cardiac arrest.
(4) Pay attention to check blood pressure and monitor ECG during medication, and provide rescue equipment.
(5) This product is a pressure vessel. Do not heat it, keep it below 40 ° C, and avoid impact or disassembly by yourself to prevent danger.
(6) Used catheters should be used after disinfection.

Lidocaine aerosol for pregnant and lactating women

This product penetrates the placenta and binds to fetal proteins higher than adults. After the mother's medication, it can cause fetal bradycardia or tachycardia, and it can also cause neonatal methemoglobinemia.

Lidocaine aerosol for children

Medication in neonates can cause poisoning, and preterm infants have a longer half-life than normal infants (3.16 hours: 1.8 hours).

Lidocaine aerosol medication for the elderly

The dosage of the elderly should be adjusted according to the needs and tolerance.

Lidocaine Aerosol Drug Interactions

(1) Combined with cimetidine and -receptor blockers such as propranolol, metoprolol and naldolol, lidocaine is inhibited by liver metabolism and lidocaine blood concentration increases, Heart and nervous system adverse reactions can occur. Lidocaine doses should be adjusted. Electrocardiogram monitoring and monitoring of lidocaine blood levels should be performed.
(2) Barbiturates can promote lidocaine metabolism. Combination of the two drugs can cause bradycardia and sinus arrest.
(3) Combination with procainamide can produce transient delirium and hallucinations, but does not affect the blood concentration of this product;
(4) Isoproterenol can increase the total clearance of the product due to an increase in liver blood flow; Norepinephrine can reduce the total clearance of the product due to a decrease in liver blood flow;
(5) Compatibility with the following drugs: phenobarbital, thiopental sodium, sodium nitroprusside, mannitol, amphotericin B, ampicillin, sulfadiazine.

Lidocaine aerosol overdose

For over-dose and individual sensitive patients, the following symptoms can occur, such as dizziness, panic, tremors, chills, etc., but also pale, sweating, chest tightness, shortness of breath, and difficulty breathing. The principle of treatment for poisoning reaction is to immediately stop drug administration, give exhaled oxygen, and give symptomatic treatment according to the condition. Excessive amounts can also cause convulsions and cardiac arrest.

Lidocaine Aerosol Pharmacology and Toxicology

Lidocaine, due to local anaesthetics of the amide type, has obvious bipolar effects on the central nervous system after blood absorption, and there is no pioneering excitement. When the blood concentration is low, analgesia, sleepiness, and pain threshold increase; As the dose increases, the effect or toxicity increases, and subcontaminated blood concentrations have anticonvulsant effects; convulsions can occur when the blood concentration exceeds 5 g · ml [sup] 1 [/ sup]. At low doses, this product can promote the outflow of k [sup] + [/ sup] in myocardial cells, reduce the 4-phase slope, slow down the diastole auto-depolarization, reduce myocardial autonomy, and have anti-ventricular arrhythmia Effect; At the therapeutic dose, it has no significant effect on the electrical activity of myocardial cells, atrioventricular conduction and myocardial contraction; further increase in blood drug concentration can cause slowing of cardiac conduction velocity, atrioventricular block, and inhibit myocardial contractility And make the heart's blood output decrease.

Lidocaine Aerosol Pharmacokinetics

After absorption, the tissue is distributed quickly and widely, and can penetrate the blood-brain barrier and placenta. Most are degraded by liver microenzymes and excreted in urine, and a small amount appear in bile.

Lidocaine Aerosol Storage

Shaded, sealed and stored in a cool place.

Lidocaine Aerosol Packaging

A total of 25 grams per bottle, aluminum can.

Lidocaine Aerosol Expiration Date

2 years ^[1]