This product is a broad-spectrum antitumor antibiotic isolated and extracted from Streptomyces cephalosporin culture medium. It has anti-cancer effects on a variety of cancers. The principle of action is to depolymerize DNA in cells and hinder DNA replication, thereby inhibiting tumor Cell division.
Mitomycin C
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This product is de novo
Molecular formula
C15H18N4O5
This product is
Intravenous, 4mg 6mg / time for adults, 1-2times / week, 40mg 60mg course of treatment. Oral, 2mg ~ 6mg / day, the total amount of 100mg ~ 150mg is a course of treatment.
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This medicine may interfere with women's
Application of mitomycin C in glaucoma surgery
The main purpose of glaucoma filtering surgery is to establish a new drainage of aqueous humor. It is an important method for treating glaucoma at present, but some patients have difficulty forming filter bubbles and the operation has failed. The main reason is that the fibroblasts under the conjunctiva and between the sclera and the fibrosis in the operating area are excessively proliferated, fibrosis, and scar formation caused by the obstruction of the filtering channel. MMC is an anti-metabolic drug. It is an anti-tumor antibiotic isolated from the streptomyces cephalosporins layer. It forms a cross-link with the double helix of DNA, destroys the structure and function of DNA, inhibits the replication of DNA during proliferation, Both cells have a killing effect, and they also act on stationary cells. Therefore, they can be used to prevent vascular regeneration in the surgical area [3], inhibit fibrous cell proliferation and scarring in the filter channel after glaucoma filtering surgery, and keep the filter channel open. Improve the success rate of surgery, but pay attention to the selection of indications and understand the prevention and treatment of toxic side effects and complications.
Most scholars at home and abroad advocate MMC for refractory glaucoma [2 ~ 5], such as filtering surgery failure eyes, uveitis secondary glaucoma, neovascular glaucoma, and aphakia. In clinical observation, we found that patients with hypotonic hypertension were all angle-closure glaucoma and had no history of surgery. Consideration is related to considering excess. Therefore, MMC is considered to be better for patients with refractory glaucoma. For those who undergo primary glaucoma surgery for the first time, the drug concentration and time should be reduced during use.
There is no definitive conclusion about the concentration of intraoperative MMC and the time for placing it under the conjunctival flap and scleral flap [2]. When we use it, we use 0.4g * L-1 for 5min for refractory glaucoma, and 0.2g * L-1 for 3min for primary glaucoma surgery, that is, pay attention to the difference in individualization. The concentration is short and the effect is good.
