What Is Ofloxacin Opthalmic?

Ofloxacin eye drops, the indications are adapted strains: Staphylococcus, Streptococcus, Pneumococcus, Enterococcus, Micrococcus, Moraxella, Corynebacterium, Kleb sensitive to this preparation B. genus, Serratia, Proteus, M. morganii, Providence, Haemophilus influenzae, Haemophilus conjunctivitis (Family-Wichia), Pseudomonas , Pseudomonas aeruginosa, Pseudomonas onion, Xanthomonas maltophilia, Acinetobacter, Propionibacterium. Adaptation symptoms: used for the treatment of blepharitis, dacryocystitis, blephaeritis, conjunctivitis, meibomitis (including corneal ulcers), and aseptic therapy for perioperative ophthalmology.

Drug Name: Ofloxacin eye drops

Drug type: Prescription drugs, topical drugs, medical insurance workers' injuries
Use classification: Other ophthalmic drugs

Ofloxacin eye drops ingredients

Chemical name: (±) -9-fluoro-2,3-dihydro-3-methyl-10- (4-methyl-1-piperazinyl) -7-oxo-7H-pyrido [1, Chemical structure of 2,3-de] -1,4-benzo * azine-6-carboxylic acid:

Molecular formula: C ₁₈ H ₂₀ FN ₃ O ₄
Molecular weight: 361.37

Ofloxacin eye drops properties

This product is a slightly yellow to pale yellow solution.

Ofloxacin eye drops indications

Applicable strains: Staphylococcus, Streptococcus, Pneumococcus, Enterococcus, Micrococcus, Moraxella, Corynebacterium, Klebsiella, Serratia, Proteus, M. morgani, Providence, Haemophilus influenzae, Haemophilus conjunctivitis (Wedii), Pseudomonas, Pseudomonas aeruginosa, Pseudomonas onion, Xanthomonas maltophilia, Acinetobacter, Propionibacterium.
Adaptation symptoms: used for the treatment of blepharitis, dacryocystitis, blephaeritis, conjunctivitis, meibomitis (including corneal ulcers), and aseptic therapy for perioperative ophthalmology.

Ofloxacin eye drops specifications

5ml: 15mg

Ofloxacin eye drops usage dosage

Usually 3 times a day, 1 drop per eye drop. Can be appropriately increased or decreased according to symptoms.

Ofloxacin eye drops adverse reactions

Of the total 13329 cases investigated, 44 (0.33%) had adverse reactions. The main adverse reactions were 11 eye irritation (0.08%), 8 eyelid itching (0.06%), 6 eyelids (0.05%), 5 conjunctival hyperemia (0.04%), and 5 eye pain (0.04%). ), 5 eyelid swelling (0.04%), etc.
1. Severe adverse reactions: shock and allergic symptoms: shock and allergic symptoms may be caused and should be fully observed. When erythema, rash, dyspnea, decreased blood pressure, eyelid edema and other symptoms are found, the drug should be stopped and treated properly.
2. Other adverse reactions: When an adverse reaction is found, proper treatment such as stopping the administration should be taken.

Ofloxacin eye drops contraindications

Patients with a history of allergies to ofloxacin and quinolones.

Ofloxacin eye drops precautions

1. This product cannot be used for a long time. In order to prevent the emergence of drug-resistant bacteria, the sensitivity should be confirmed in principle, and the period of medication should be limited to the minimum time required to treat the disease.
2. This product is for eye drops only.
3. In order to prevent contamination of the medicinal solution, care should be taken to prevent the front end of the container from directly contacting the eye when dropping the eye.

Ofloxacin eye drops for pregnant and lactating women

For pregnant women or women who may become pregnant, they should only be administered when the benefits of their treatment are higher than the risks that may occur. (Unknown for safety during pregnancy)

Ofloxacin eye drops for children

According to foreign data, 2 cases (eyelids, eyelid swelling) were found in 496 users under 1 year old, and 2 cases were found in 1657 users from 1 to 15 years old. 3 (Swelling of eyelids, conjunctival congestion, itching).

Ofloxacin eye drops for elderly

In general, the physiological function of the elderly is reduced, and attention should be paid to reducing it.

Ofloxacin eye drops drug interactions

still uncertain.

Ofloxacin eye drops overdose

still uncertain.

Ofloxacin Eye Drops Clinical Trial

1. Clinical effects on various diseases: For patients with infectious diseases other than the eye, this product was subjected to a double-blind test and a comparative test of arbitrary methods. The clinical effects of various diseases on 391 clinical trial cases are shown in the table below. .

*: When multiple diseases are complicated, each disease is counted as one case.
*: Excluding trachoma.
2. Clinical effects on each effective strain: The clinical effects of each effective strain in the 391 cases mentioned above are shown in the table below.

*: When multiple strains are detected, each strain is counted as one case.
3 Effect on perioperative aseptic treatment in ophthalmology: 367 cases of ophthalmic surgery patients were used as the perioperative aseptic therapy. This preparation was used, and no postoperative infection was found in all cases.

Ofloxacin eye drops pharmacology and toxicology

Pharmacological action 1. Mechanism of action: Ofloxacin specifically hinders the DNA synthesis of bacteria, the antibacterial effect is bactericidal, bacteriolysis occurs at mlC concentration.
In addition, this product can destroy the protozoa of Chlamydia trachomatis developmental ring.
2. Antibacterial effect: The antibacterial spectrum of ofloxacin is extensive. The in vitro test results of this product show that Gram-positive bacteria such as Staphylococcus, Streptococcus, Pneumococcus, Corynebacterium, and Pseudomonas including Pseudomonas, Haemophilus influenzae, and Conjunctiva Gram-negative bacteria, such as Haemophilus bacillus (Korean-Wichia), Moraxella, Serratia, Klebsiella, Proteus, Acinetobacter, and Anaerobic Pathogenic bacteria that cause eye infectious diseases such as propionibacterium have a strong antibacterial effect. In addition, this product has anti-chlamydia activity, has antibacterial effect on Chlamydia trachomatis, and it is difficult for Chlamydia to develop resistance to this product.
Toxicology 1. Acute toxicity

2. Eye drop toxicity: No eye irritation or eye poisoning 3. Antigenicity: None.

Pharmacokinetics of ofloxacin eye drops

1. Blood concentration in healthy adults: 1 drop every 30 minutes, 16 drops in the eye, or 1 drop every 15 minutes, and 32 drops in the eye. The blood concentration after 30 minutes is 0.09 g / ml, 0.034, respectively. g / ml, then gradually decreased.
2. Intraocular distribution For cataract patients every 5 minutes before surgery, a total of 5 eye drops, the concentration of aqueous humor showed the highest value (1.20 g / ml) about 1 hour after eye drops.
3 Distribution in the ocular tissues of animals (white rabbits, dogs using Telitox eye drops, 1 normal eye drop on a normal white rabbit, one eye drop to the cornea, bulbar conjunctiva, eye muscle, sclera, iris, ciliary The distribution of body and aqueous humor is good. The corneal, sclera, eye muscle, iris, and ciliary body have the highest 1-hour values, which are 3.32 g / ml, 1.62 g / ml, 2.62 g / ml, 0.95 g / ml. The bulbar conjunctiva The highest value for 15 minutes was 2.95 g / ml. The highest value for anterior aqueous 30 minutes was 0.71 g / ml. For normal white rabbits, the eyes were dropped once every 5 minutes, 1 drop each time, and 5 times when the eyes were dropped, Like the above one eye drop, it showed a good distribution in the eye tissue. Five minutes after the eye drop, the cornea, sclera, bulbar conjunctiva, and vitreous showed the highest values, 7.78 g / ml, 7.66 g / ml, 34.98 g / ml, 0.95 g / ml. In addition, the maximum value of 15 minutes in the eye muscle is 18.54 g / ml, and the maximum value of 30 minutes in the iris and ciliary body is 3.12 g / ml. The maximum value for 1 hour is 3.56 g / ml. In addition, the Bigger dog was treated with an optically active form of Lofloxacin (L body) 0.3% levofloxacin eye drops once a day, 4 times a day. For 2 consecutive weeks of eye drops, the concentration in the eye tissue 24 hours after the last eye drop was: 39.49 g / ml for the iris and ciliary body, and 12.3 g / ml for the choroid and retinal pigment epithelium. The eye tissue contains melanin The tissues showed a high distribution, while the distribution to the retinas other than the pigment epithelium was only trace.

Ofloxacin eye drops storage

Store in a sealed container at 1-30 ° C.

Ofloxacin Eye Drops Packaging

Plastic eye drop container, 1 stick / box.

Ofloxacin eye drops expiration date

36 months.

Ofloxacin Eye Drops

JX200L0053 ^[1]