What is the connection between statins and myalgia?

Myalgia or common muscle pain is one of the most common adverse side effects of statin therapy, occurring in about 5% of all patients. The growing reliance on Western society statins has led to increasing awareness in the medical community of this context between statins and myalgia, although both the nature of the connection and its prevention is less than clear. Myalgia is most often caused by some kind of trauma, such as excessive stretching or excessive use of the muscle group or individual muscles. If trauma is not easily identifiable, they may be the cause of viral infection. For example, muscle pain is one of the symptoms of flu. These drugs are primarily used to reduce cholesterol levels in the human bloodstream, leading to a dramatic reduction in cardiovascular diseases. Atorvastatin, the most popular statins, is sold under the Lipitor® brand. Research also shows that statin therapy may be useful in reducing the occurrence of certain cancer types in some patientsat. These real and potential advantages of statin therapy can be considered as a prevailing to the disadvantage of the potential connection between statins and myalgia.

In a significant subset of cases, it was found that in some patients with statin therapy who had a lack of vitamin D, the connection between statins and myalgia was expressed in Western culture. The correction of vitamin D deficiency led to a satisfactory solution of myalgia. However, vitamin D deficiency does not explain all incidents of myalgia in patients undergoing statin therapy; Similarly, there is no connection between statins and myalgia in most patients with vitamin deficiency.

There is no mechanism that prescription can determine which of the many statins will cause myalgia in any particular patient. Similarly, if the patient experiences a disorder, there is no way to find out what the difference will be if the therapy is changed to one of the otherStatins. Some statins such as orthopic and fluvastatin are hydrophilic than other statins; This means that they dissolve the most easily in water, while other statins are lipophilic, which means that they dissolve most in fats or oils. It has been suggested that it is easier for lipophilic statins to penetrate into cell membranes and cause damage, leading to myalgia, but inadequate research has been carried out in these lines.

Examination of the relationship between statins and myalgia has led to the discovery that other statins, lovastatin, lead to an expression of a gene that is expected to support muscle fibers damage. However, the actual incidence of myalgia among Lovastatin users does not delay the existence of a strong causal relationship.