What Is Phentolamine Mesylate?

Phenol tolamine mesylate, the indication is for the treatment of erectile dysfunction.

Drug Name: Phentolamine mesylate

Drug type: prescription
Use classification: Vasodilators

Ingredients of phentolamine mesylate tablets

Phenyltolamin mesylate, chemical name: 3-{[(4,5-dihydro-1H-imidazol-2-yl) methyl]-(4-tolyl) amino} phenol mesylate

Phentolamine mesylate tablet properties

This product is an orange-red triangle.

Indication of phentolamine mesylate

For the treatment of erectile dysfunction.

Phentolamine mesylate tablets specifications

40mg

Phentolamine mesylate tablets dosage

Oral, 40mg each time, taken 30 minutes before sexual life, up to one time a day, according to need and tolerance, the dose can be adjusted to 60mg, the maximum recommended dose is 80mg.

Adverse reactions of phentolamine mesylate

Nasal congestion, palpitations, flushing, dizziness, fatigue, chest tightness and other adverse reactions are common. A small number of patients may have mild changes in heart rate, systolic and diastolic blood pressure, and very few patients may have orthostatic hypotension.

Contraindications of phentolamine mesylate

Low blood pressure (systolic blood pressure <90mmHg, diastolic blood pressure <60mmHg), severe arteriosclerosis, angina pectoris, myocardial infarction, liver and kidney dysfunction, patients with gastric ulcer and those allergic to this product are prohibited.

Precautions for phentolamine mesylate

1. The elderly are more likely to induce hypothermia with this product.
2. Coronary artery insufficient blood supply, mental patients, diabetic patients with caution.

Phentolamine mesylate tablets drug interactions

1. This product is used in combination with guanethidine to increase the incidence of orthostatic hypotension or bradycardia.
2. Sedative and hypnotic drugs such as phenobarbital and glummit; reserpine and antihypertensive drugs can strengthen the antihypertensive effect of this drug.
3. When combined with cardiac glycoside, it can enhance its toxic response.
4. Avoid using with iron.
5. Prohibition of combination with nitroglycerin drugs.

Pharmacology and toxicology of phentolamine mesylate

This product is an alpha adrenergic blocker, which has effects on both alpha ₁ and alpha ₂ receptors, which dilates blood vessels and reduces the resistance of surrounding blood vessels, relaxes the smooth muscle of the penile cavernous body, and allows blood to flow more into the cavernous tissue At the same time, it inhibits blood flow from the cavernous body, leading to an erection. The drug can maintain erectile function without being affected by sex hormones, emotions and nerves, and can maintain and promote long-term erection. The recommended dose of the drug has no effect on those who lack sexual stimulation.

Pharmacokinetics of phentolamine mesylate

This product is taken orally at 40 mg, and the peak plasma concentration is reached within 30 minutes. The C _max is 33 mg / L, and the effective concentration can be maintained for 2 hours. The drug is mainly metabolized by the liver, and about 13% of the drug is excreted from the urine in its original form. The binding rate of this product to serum protein is 54%.