What Is Protamine Sulfate?
Protamine sulfate is also called protamine sulfate. Strong alkaline protein sulfate isolated from male germ cells or fish white.
Protamine sulfate
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- Chinese name
- Protamine sulfate
- Protamine sulfate is also called protamine sulfate. Strong alkaline protein sulfate isolated from male germ cells or fish white.
- White, light grayish yellow amorphous or crystalline powder. Soluble in hot water, ammonia, dilute acid, hardly soluble in water, ethanol, insoluble in chloroform and ether. The acidic group of heparin is an essential group to maintain the anticoagulant activity of heparin. Protamine can quickly bind to the acidic group of heparin, which makes heparin lose its anticoagulant activity. It can be used as a heparin antagonist in therapy, and can also take advantage of its ability to bind with other proteins and polypeptides. It often forms complexes with insulin, corticotropin, etc. for the preparation of long-acting preparations. [1]