What Is Sibutramine Hydrochloride?

Sibutramine Hydrochloride belongs to serotonin and norepinephrine reuptake inhibitors. It has dual effects of suppressing appetite and enhancing metabolism. It is used for the treatment of obesity that cannot be controlled by diet and exercise.

Sibutramine hydrochloride

Sibutramine Hydrochloride belongs to serotonin and

Drug Name: Sibutramine Hydrochloride

Drug aliases: Zhengqing Goblin,

Body mass index (BMI) calculation: weight (kg) divided by height (m) squared (kg / m2). The recommended starting dose is 10 mg once daily, which can be taken alone or with food in the morning. If the weight loss is insufficient, the dose can be adjusted to 15 mg per day after 4 weeks. If the patient cannot tolerate the 10 mg dose, it can be reduced to 5 mg. The dose should be adjusted according to the patient's blood pressure and heart rate. Do not recommend doses above 15mg / day.

Contraindicated for acceptance

Two studies abroad on the possibility of heart valve disease: in one study 210 patients (mean age 54 years) used 2D and color Doppler

On October 30, 2010, China's State Food and Drug Administration issued a notice:

[Efficacy Indications] Sibutramine hydrochloride is suitable for the treatment of obesity that cannot be reduced and controlled by diet control and exercise, including weight loss and weight loss maintenance. Treatment should be combined with low-calorie diet and exercise. Recommended for the treatment of obesity patients with a body mass index 30kg / m2 or 27kg / m2 (with other risk factors such as hypertension, diabetes, dyslipidemia, etc.). [Chemical composition] The main ingredient of this product is sibutramine hydrochloride.

[Pharmacological action] This product is a therapeutic agent for obesity that acts on the central nervous system. It works mainly through its amines (secondary and primary amines) metabolites. Its main mechanism is to inhibit the reuptake of norepinephrine, serotonin and dopamine and enhance satiety. There was no significant effect on the release of serotonin and dopamine. Studies have also shown that this product and its amine-active metabolites have no significant anticholinergic, antihistamine, and monoamine oxidase inhibitory effects.

[Drug interaction] 1 product cannot be used at the same time with monoamine oxidase inhibitor (MAOI). MAOI should be discontinued for at least 2 weeks before starting treatment with this product; this product should be discontinued for at least 2 weeks before using MAOI.

2 Since this product inhibits serotonin reuptake, it should not be used in combination with other serotoninergic drugs.

3 Use this product with caution in patients taking medicines that affect blood pressure and heart rate, including norephedrine, ephedrine, and pseudoephedrine.

The 4th product has potential interactions with drugs that inhibit the metabolism of cytochrome P450 (3A4), such as ketoconazole and erythromycin, but the effect is not significant.

[Adverse reactions] The most common adverse reactions of this product are: dry mouth, anorexia, insomnia, constipation, etc. Other adverse reactions that occurred in clinical trials at a rate of 1% were: systemic reactions: fever.

Cardiovascular system: fast heart rate and high blood pressure.

Respiratory system: tracheitis, dyspnea.

Digestive system: diarrhea, gastroenteritis, dental disease, flatulence.

Nervous system: restlessness, limb cramps, increased tension, abnormal thinking, seizures.

Urogenital system: interstitial nephritis, menstrual disorders.

blood system: skin ecchymosis caused by prolonged bleeding time.

Metabolism and nutrition: peripheral edema.

Muscle / skeletal system: arthritis.

skin and related tissues: itching.

Special feeling: amblyopia. Laboratory tests: Sibutramine hydrochloride can cause abnormal liver function tests, including increases in AST, ALT, GGT, LDH, alkaline phosphatase, and bilirubin. The test values are mostly slightly increased, often with further Treatment disappeared without a clear dose-reflection relationship.

[Contraindications] 1 It is contraindicated for patients receiving monoamine oxidase inhibitor (MAOI) treatment.

2 It is contraindicated for patients who are allergic to the ingredients of this product.

3 Contraindications for patients with anorexia nervosa.

4 Contraindications for patients receiving other central appetite suppressants.