What Is Tetrahydrozoline?

Tetrahydrozoline, also known as tetrahydronaphthalidazole, molecular formula: C ₁₃ H ₁ ₆ N ₂ , white or almost white crystalline powder crystalline powder compound. Clinically, this product is a sympathomimetic drug, which has vasoconstrictive effect, and can quickly eliminate nasal mucosa and conjunctival congestion. ^[1-2]

Chinese name: Tetrahydrozoline
Foreign name: Tetrahydrozoline

Molecular formula: C13H16N2
Molecular weight: 200.2795
Boiling point: 393.5ºC

Tetrozoline compounds

Tetrahydrozoline Basic Information

Chinese name: Tetrahydrozoline

Chinese alias: tetrahydrozoline; 4,5-dihydro-2- (1,2,3,4-tetrahydro-1-naphthyl) -1H-imidazole

English name: tetryzoline

English alias: Tetryzoline; 2- (1,2,3,4-tetrahydronaphthalen-1-yl) -4,5-dihydro-1H-imidazole; tetrahydrozoline; Tyzanol; Tetryzolin

Molecular formula: C ₁₃ H ₁₆ N ₂

Structural formula:

Molecular weight: 200.28000

Exact mass: 200.13100

CAS number: 84-22-0

PSA: 24.39000

LogP: 1.87260 ^[3]

Tetrahydrozoline physical properties

Density: 1.2 g / cm3

Solubility: soluble in water (1: 3.5), soluble in ethanol (1: 7.5); very slightly soluble in chloroform; almost insoluble in ether

Boiling point: 393.5ºC at 760 mmHg

Flash point: 191.8ºC

Refractive index: 1.656 ^[3]

Tetrahydrozoline synthetic route

Figure: ^[3]

Pharmacological effects of tetrahydrozoline

Tetrahydrozoline is a sympathomimetic drug with vasoconstrictive effect. It can act on adrenaline alpha receptors on nasal mucosa blood vessels, constrict nasal mucosa blood vessels, increase patency of the nasal cavity, and improve the symptoms of nasal congestion in allergic rhinitis. ^[4] ^[2]