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Paracetamol promethazine injection, used for fever, headache, joint pain, neuralgia and dysmenorrhea.

Drug Name: Paracetamol promethazine injection

Paracetamol Promethazine Injection Ingredients

This product is a compound preparation containing 200 mg of acetaminophen and 10 mg of promethazine hydrochloride per 2 ml.

Traits of acetaminophen promethazine injection

This product is colorless or slightly yellow clear liquid.

Indications of acetaminophen promethazine injection

For fever, headache, joint pain, neuralgia and dysmenorrhea.

Dosage and dosage of acetaminophen promethazine injection

Intramuscular injection. 2ml at a time or as directed by your doctor. Children take acetaminophen 5 mg / kg at a time.

Adverse effects of paracetamol and promethazine injection

1. Drowsiness, dizziness, dry mouth, increase skin sensitivity to light.
2. At regular doses, there are few adverse reactions to acetaminophen, which can occasionally cause nausea, vomiting, sweating, abdominal pain, pale skin, etc. In a few cases, allergic dermatitis (rash, itching, etc.), and granulocyte deficiency , Thrombocytopenia, anemia, liver damage, etc., rarely cause gastrointestinal bleeding.
3. Cardiovascular adverse reactions are rare, showing increased blood pressure and occasionally a slight decrease in blood pressure. Reduced blood cells. Granulocytopenia and aplastic anemia are rare.

Paracetamol Promethazine Injection Contraindications

1. Those who are allergic to the ingredients in this product are prohibited.
2, severe liver and kidney dysfunction are disabled.
3. Disabled in patients with severe hypertension.
4, pregnant women are disabled.
5, children under 3 months disabled.

Precautions for acetaminophen promethazine injection

1. The following situations should be used with caution:
1) When alcohol poisoning, liver disease or viral hepatitis, there is a danger of increasing liver toxicity.
2) Renal insufficiency, although it can be used occasionally, but if used for a long time, there is a risk of increasing renal toxicity.
3) Use with caution in patients with gastric ulcer.
2. Acute asthma, bladder and neck obstruction, bone marrow suppression, cardiovascular disease, coma, angle-closure glaucoma, liver dysfunction, hypertension, gastric ulcer, prostatic hypertrophy, pyloric or duodenal obstruction, respiratory disease (Especially children, sputum is thick after taking this product, which affects sputum excretion, and can suppress cough reflex), patients with epilepsy (injection can increase the severity of convulsions), jaundice, various liver diseases and renal failure, Reyei's syndrome (extrapyramidal symptoms caused by promethazine can be easily confused with Reyei's syndrome) in patients with caution.
3, during long-term treatment should regularly check blood and liver function.
4. Interference to diagnosis, blood glucose measurement, false low value can be obtained when measured by glucose oxidase method, but no effect when measured by hexokinase / 6-phosphate dehydrogenase method; serum uric acid measurement, phosphorus tungsten A false high value can be obtained when the acid method is used for determination; urinary 5-hydroxyindole acetic acid (5-HIAA) can be used for a qualitative screening test using a nitrite naphthol reagent, and a quantitative test is not affected.
5. Cross-allergic reaction: Those who are allergic to aspirin generally do not have an allergic reaction to this product, but it has been reported that a small number (5%) of patients with wheezing due to aspirin allergy may develop mild bronchial after the application of acetaminophen Spastic response; patients who are known to be highly allergic to phenothiazines are also allergic to this product.
6. Promethazine has a sedative and hypnotic effect in this product. It should not be used by anyone who drives, ships, operates at height or operates machinery.

Acetaminophen Promethazine Injection for pregnant and lactating women

Pregnant women taking promethazine hydrochloride can induce jaundice and extrapyramidal symptoms in infants. Paracetamol can pass through the placenta, and it should be considered that pregnant women may have adverse effects on the fetus after using this product. Therefore, pregnant women are prohibited. Although no excretion of this product or its metabolites has been found in the urine of nursing infants, breastfeeding women can reach a certain concentration in their milk after taking this product, so it is not recommended for breastfeeding women.

Paracetamol Promethazine Injection for Children

Drug metabolism enzymes in children less than 3 months may be insufficient and banned.

Paracetamol and Promethazine Injection for Elderly

Elderly people who use promethazine hydrochloride are prone to dizziness, sluggishness and hypotension.

Drug interactions of paracetamol and promethazine injection

1. Paracetamol:
1) Long-term use of this product in patients who have been drinking alcohol or using other liver enzyme inducers, especially barbiturates or anticonvulsants, has a greater risk of liver toxicity.
2) Combined with chloramphenicol, it can extend the latter's half-life and enhance its toxicity.
3) Contract with anticoagulant drugs can enhance anticoagulant effect, so the dosage of anticoagulant drugs should be adjusted.
4) When combined with aspirin and other non-zizi anti-inflammatory drugs for a long time, there is a danger of significantly increasing renal toxicity.
5) When combined with the antiviral drug Zidovudine, its toxicity can be increased, and simultaneous application should be avoided.
2. Promethazine hydrochloride:
1) Ethanol or other CNS inhibitors can enhance the effects of promethazine or (and) these drugs.
2) Anticholinergic drugs, especially atropine and promethazine, have an enhanced antimuscarinic effect when used together.
3) Ototoxicity adverse reactions such as cisplatin, paromomycin and other aminoglycoside antibiotics, salicylic acid preparations and vancomycin can be masked when used with promethazine.
4) Not suitable for injection with aminophylline.

Pharmacology and Toxicology of Paracetamol Promethazine Injection

Paracetamol in this product is an acetanilide antipyretic and analgesic, which produces analgesic effects by inhibiting prostaglandin synthesis (inhibiting prostaglandin synthase) and blocking the impulses of painful nerve endings, which may be related to inhibiting the prostate And other substances that can sensitize the pain receptors (such as serotonin, bradykinin, etc.). The antipyretic effect is to produce dilated peripheral blood vessels through the hypothalamus temperature regulating center, and to increase the blood flow, sweating and heat loss of the skin. Promethazine hydrochloride is a phenothiazine antihistamine, which has an antihistamine effect and competes with the histamine released by tissues for H1 receptors, as well as sedative, hypnotic and antiemetic effects.

Pharmacokinetics of Paracetamol Promethazine Injection

Paracetamol is evenly distributed in body fluids after absorption, and about 25% binds to plasma proteins. At a small amount (blood concentration <60ug / ml), the binding to protein is not obvious, and the binding rate is high at a large or poisoned amount, which can reach 43%. 90% -95% of this product is metabolized in the liver, mainly combined with glucuronic acid, sulfuric acid and cysteine. Intermediate metabolites have toxic effects on the liver. The half-life (t _1/2 ) is generally 1-4 hours (average 2 hours). Renal insufficiency does not change, but it may be prolonged in some patients with liver disease, it may be prolonged in elderly and newborns, and in children shorten. After the administration of promethazine hydrochloride, the absorption was fast and complete, and the plasma protein binding rate was high. After intramuscular injection, the onset time is 20 minutes, and after intravenous injection, it is 3-5 minutes. The antihistamine effect generally lasts 6-12 hours, and the sedative effect can last 2-8 hours. It is mainly metabolized in the liver, and inactive metabolites are excreted in urine, and excretion is small in feces.

Storage of acetaminophen promethazine injection

Protected from light and sealed.

Paracetamol Promethazine Injection Packaging

10 sticks / box, packed in ampoules.

Expiration Date of Acetaminophen Promethazine Injection

Tentative 2 years.

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