What is the connection between hesperidine and diosmin?

Diosmin is derived from hesperidine, which comes from citrus plants and belongs to the flavonoid group of substances. Pharmaceutical manufacturers commonly combine both hesperidine and diosmin into one formulation as a phlebotropic drug, which means that the substance benefits the vascular structure. Companies partly convert hesperidine into diosmin and sell a combination that usually contains 90% diosmin and 10% of hesidin. While these wording require a prescription in parts of Europe, Hesperidin and Diosmin retail as food supplements in other parts of the world. Flavonoids also inhibit activation of thromboxan and prostaglandin. These effects prevent the occurrence of inflammatory reactions and some believe that the substance can minimize allergic reactions. Doctors commonly prescribe hesperidine and diosmin for patients who are concerned about hemorrhoids. Patients Experience reduced pain, swelling and itching while taking a combined formula. Some research led a doctor to believe that venous insufficiency and flap failure were partcaused by inflammatory conditions. Individuals also use herbal derivative to treat varicose veins. Along with the anti -inflammatory effects, the benefits of diosmine include vascular protection by preventing cellular adhesion to the blood vessel lining, which improves circulation and minimizes damage to the endothelial wall. Some doctors use hesperidine and diosmin products to treat vascular insufficiency and venous stasis.

doctors claim that improved circulation effects of hesperidine and diosmin increase the healing rate in patients diagnosed with venous stasis ulcers. The provision of health care offers a combination of preparation for improving circulation in patients suffering from lymphedema, secondary to breast cancer surgery. Some studies suggest that the benefits of diosmin include the ability to clean up free radicals, providing antioxidant activity.

Healthcare providers generally prescribe combinations of hesperidine and diosmin for the time of the SESthose months or less. Patients diagnosed with hemorrhoids initially take 1,500 milligrams (1,350 milligrams Diosmin/150 milligrams of hesperidine) twice or three times a day for four days. Then they take 1,000 milligrams for three days (900 milligrams Diosmin/100 milligrams of hesperidine). A dose of 500 milligrams (450 milligrams diosmin/50 milligrams of hesperidine) is prescribed for up to two months to prevent the occurrence of hemorrhoids. Patients suffering from circulatory problems take a physician recommended daily doses of combined formulation for two to six months.

Doctors advise patients to grant a healthcare provider before starting any herbal supplement. The reported side effects by combinations of diosmin/hesperidine are generally mild. Some patients experience abdominal discomfort, diarrhea and headaches. Doctors do not recommend a herbal supplement for patients taking anticoagulant drugs that include aspirin or warfarin because hesperidine and diosmin may increase the effecty these medicines. Bioflavonoid also disrupts the effects of drugs blocking calcium channel. Individuals should not take herbal supplement while taking tamoxifen.