What Is Topical Estrogen?

A variety of estrogen is pregnant horse urine extract, which has obvious estrogen activity, stimulates insulin-like growth, transforms growth factor beta (TGF-), promotes the formation of bone collagen and inhibits bone resorption.

Multiple estrogen

A variety of estrogen is pregnant horse urine extract, which has obvious estrogen activity, stimulates insulin-like growth and transforms growth

1. Tablets: 0.25mg, 0.3mg, 0.625mg, 1.25mg, 2.5mg each;

2. Ointment: 1g (625g);

3. Injection: 20mg (1ml).

Oral rapid absorption, bioavailability is 40% to 50%, first pass effect is about 60%, the peak time of plasma drug concentration is 1 to 2 hours, and the second peak of blood concentration occurs about 12 hours after administration, indicating that a variety of Hormones circulate through the liver and intestines and are absorbed again by the small intestine. More than 93% exist in the form of sulfate and gluconate in plasma, and can bind to plasma proteins moderately. The plasma half-life is 6 to 14 hours. A variety of estrogen is metabolized in the liver, most of which are excreted as the original drug, about 60% are excreted from the urine, and some are excreted from the feces. A variety of water-soluble estrogen is strongly acidic, ionized in body fluids, easily excreted from the kidney, and renal tubular reabsorption is rare. Local vaginal medications have less systemic absorption.

1. Mainly used to treat the symptoms of estrogen deficiency caused by natural menopause or surgical menopause, especially moderate and severe vasomotor symptoms such as facial flushing and atrophic vaginitis.

2. Used for hypogonadism and primary ovarian failure.

3. Treatment of functional uterine bleeding.

4. Prevention and treatment of osteoporosis associated with estrogen deficiency, preferably with calcium.

5. Palliative treatment of breast cancer bone metastasis or prostate cancer.

6. For nosebleeds, gynecological and obstetric bleeding and bleeding during surgery. Ovarian insufficiency, uterine hypoplasia, perimenopausal syndrome, senile vaginitis, prostate cancer.

Pregnancy

2. Known or suspected breast cancer.

3. Estrogen-dependent tumors and endometriosis.

4. Unexplained vaginal bleeding.

5. Thrombotic disease.

6. Allergic to any component of multiple estrogen.

1. (1) A variety of estrogen is metabolized by the liver, so those with impaired liver function should be used with caution. (2) Patients with bone metabolism diseases caused by hypercalcemia should use a variety of estrogen with caution.

2. For women who have not removed the uterus, in order to avoid estrogen-induced endometrial hyperplasia, periodic medication is recommended, which is called cyclic sequential therapy, which is suitable for perimenopausal women, that is, continuous use for 3 weeks (1-21 days) The drug was stopped for 1 week (22-28 days); on the 12th to 21st days, medroxyprogesterone was added 4 mg daily to protect the endometrium. However, this cycle of sequential treatment, bleeding every month after stopping the drug, brings inconvenience to menopausal women. In recent years, simultaneous application or alternate application of estrogen and progesterone is called continuous combination therapy. Women who have had their uterus removed do not need to use progestin.

3. A variety of estrogen can be used with normal saline or dextran, avoiding compatibility with acidic solutions.

4. The effects of drugs on pregnancy: The use of estrogen during pregnancy can increase the risk of abnormal fetal reproductive organ development, and vaginal adenopathy, cervical squamous epithelial hyperplasia, or cervical cancer risk increase in adult girls.

5. The effects of drugs on breastfeeding: a small amount of various estrogen can be secreted with milk.

6. The effect of drugs on test values or diagnosis: multiple estrogen can increase blood triacylglycerol.

7. A comprehensive medical history inquiry and physical examination should be done before starting treatment, including breast examination, blood pressure, pelvic examination and cervical cytology examination. At least once a year thereafter, women who take the drug should regularly check the thickness of the breast and endometrium.

8. Longer-term and larger doses can increase the risk of uterine adenocarcinoma and breast cancer, so progestogens must be added to combat them.

9. Heart, liver, kidney disease, hypertension, diabetes or asthma patients should be used with caution, breastfeeding should not be used. Multiple estrogen can cause condom failure. When using the medicine, squeeze from the bottom of the ointment to make enough cream (0.5 ~ 2g) to enter the nozzle of the applicator. After inserting the applicator deep into the vagina, push the plunger down until it returns to its original position. Remove the plunger from the round tube and wash it with soap and warm water for later use.

1. Taking multiple estrogen may have nausea, vomiting, and abdominal distension; menstrual changes, breakthrough bleeding, spotting bleeding, amenorrhea; original uterine fibroids enlarge; breast enlargement and pain; melasma, hair loss, rash; Retention of body fluids worsens related symptoms such as asthma, epilepsy, migraine, heart and kidney disease; corneal flexion becomes steeper, unable to wear contact lenses; weight gain or loss, edema, etc.

2. The use of multiple estrogen alone will increase the risk of endometrial adenocarcinoma.

3. Increase the risk of breast cancer to a certain extent, especially those who have used it for more than 10 years.

4. Multiple estrogen may increase the risk of gallbladder disease.

5. There is evidence that multiple estrogen can change certain clotting factors and promote thrombotic diseases.

1. Usually 20mg each time. For dysfunctional uterine bleeding, oral administration of 2.5 to 7.5 mg per day after injection is effective for 20 days (with progestin for the last 5 days). It is also used as follows: for dysfunctional uterine bleeding, the oral administration is changed to 7.5 mg per day after the injection has taken effect. After 2-3 days of bleeding, it is reduced to 5 mg per day, and then gradually reduced to 0.625 mg per day for 20 days. The last 5 days Plus progestogen intramuscular injection, 20mg progesterone daily.

2. Oral administration: usually 0.5 to 2.5 mg each time, 1 to 3 times a day. (1) Perimenopausal syndrome: 0.625 to 3.75mg per day. It also has the following usage: 0.3 0.625mg, which can be applied sequentially and periodically. (2) Prostate cancer: 7.5mg per day. (3) Prevention of osteoporosis: 0.625 mg per day. (4) Estrogen replacement therapy and menstrual disorders for menopausal women with low estrogen: 0.3mg or 0.625mg per day, which can be applied sequentially or continuously. (5) Dysfunctional uterine bleeding: see intramuscular injection. (6) For uterine hypoplasia and oligomenorrhea: 0.5 to 2.5 mg each time, 2 to 3 times a day; (7) For prostate cancer: 5 to 7.5 mg each time, once a day. Atrophic vaginitis: 900 ~ 1250 g per day, administered periodically.

3. Vaginal administration: Give 1g of vaginal ointment in the vagina every day, containing 0.625mg of Primalin, 3 weeks as a course of treatment.

1. When combined with anti-tuberculosis drug rifampicin, it can reduce the effect due to liver enzyme induction to enhance the metabolism of various estrogen.

2. Smoking can increase the risk of serious adverse reactions of various estrogen, and it increases with the increase of smoking volume and the age of smokers.

A variety of estrogens are pregnant horse urine extracts, which are conjugated estrogen, mainly estrone, equine estrone, and 17-alpha dihydroestrone estrone sulfate, which have obvious estrogen activity. In addition, in patients with osteoporosis associated with estrogen deficiency, a variety of estrogen can promote calcitonin secretion, reduce bone response to parathyroid hormone, and play a role in promoting collagen formation and inhibiting bone resorption, respectively. A variety of estrogen still has a good hemostatic effect. Its effect is the same as that of estrone and estradiol. It is especially effective when taken orally. It is not easy to be inactivated by the liver and has less side effects. Still can promote the increase of acidic mucopolysaccharides around blood vessels, and increase the function of capillaries and small blood vessels. At the same time, it can increase prothrombin and V factor, and can control capillary bleeding and surgical bleeding. It can also be injected intramuscularly, which takes effect after 15-60 minutes. Its effect is the same as that of estrone and estradiol. Through the local application of estrogen, it can effectively regulate and regulate the reproductive system disorders caused by menopause. Local vaginal medications have less systemic absorption. Clinically used to treat vaginitis.

A variety of estrogen is a kind of estrogen extracted from natural substances. It is a mixture of common substances extracted from the urine of pregnant mares. It can effectively control vaginal and urogenital disorders caused by tissue changes associated with menopause. It is suitable for the treatment of menopause, prevention of osteoporosis, abnormal uterine bleeding caused by hormonal imbalance, atrophic vaginitis, and certain cancers.