What is xanthin oxidase?
xanthin oxidase (XO or XOA) is an enzyme that catalyzes the chain reactions of hypoxanthin oxidation to xanthin and xanthin oxidation to uric acid and hydrogen peroxide (H2O2). Oxidation requires the addition of oxygen and water. This process is important because it explains how people are able to metabolize nitrogen compounds called Purina. In oxidation Sulfhydryl, an organic compound containing sulfur rather than water is used. Xanthine dehydrogenase is also able to catalyze purine oxidation. Substrates for this enzyme include xanthin, nicotinamide adenin dinucleotide and water.
As an enzyme, xanthin oxidase is classified as a protein. It is mainly produced and is located in the liver. When the liver is damaged, liver cells release Xanthine oxidase into Blood. Therefore, if the doctor suspects that the patient has a problem with the slaughter, the blood test for this enzyme may be required.
The molecular weight of this enzyme is 270,000 units. Its catalytic effect is due to the presence of two atoms of molybdenum,Eight iron atoms and two flavin molecules. It contains metals molybdenum and iron, so xanthin oxidase is also classified under a group of metalloproteins.
lack of xo or its relatives can lead to a state called Xanthinuria. When this enzyme is missing, Xanthine accumulates in the blood. Unresolved high concentrations of xanthin can eventually overload the kidneys and lead to kidney failure. This condition has no definitive treatment yet. However, people who are affected are recommended to give up highly clean foods such as meat and legumes, and drink a lot of water to help kidneys.
alternatively, human -human xanthin oxidase may have due to lack of minerals of molybdenum or iron. In this case, nutritional supplementation is usually implemented. Molybdenum can be delivered in the form of sodium molybdate or ammonia molybdet. Iron can be delivered in the form of iron compounds such as sulfIron and iron gluconate.
When a person consumes too many purine or when xanthin's body oxidase is excessive, excessive uric acid levels can be produced, leading to a condition called hyperuriceemia. Too much uric acid in the body can lead to gout, kidney stones and kidney failure. To avoid these consequences, people who have hyperurikemia are recommended to reduce intake of purine -rich foods and are prescribed XO inhibitors. Examples of XO inhibitors are alopurinol, oxypurinol and Febuxostat.