What factors affect circulating progenitor cells?
circulating progenitor cells are a special type of cell that can travel through the body and distinguish to many types of tissues. There are many chemical factors that can affect migration and the development of circulating progenitor cells. For example, nerve progenitor cells may develop into neurons (gray matter) or gli cells (white matter) in the presence of certain growth factors found in the brain. Progenitor cells have receptors for these factors that help cells identify when and where they are most needed.
neural progenitors are influenced by the same molecules that help grow and distinguish other types of tissues. These molecules include growth factors that naturally occur in fetal development. Placing nerve progenitor cells near factors such as epidermal growth factor and fibroblastic growth factor-2 cause it to multiply rapidly.
When growth factors are removed, progenitor cells begin to differentiate both neurons, tAK for gli cells. Other growth factors may stimulate circulating progenitor cells to become muscle, bones or other types of tissues. This system allows the body to carefully control the number of cells available to recover injury and tissue injury. When new tissue is needed, the cells release a suitable growth factor for attracting progenitor cells.
Peptide called substance P is another factor that attracts circulating progenitor cells. The substance P usually causes an increase in nerve progenitor cells after exposure. Research found that when the brain is damaged, cells near the fabric P fabric P to attract more progenitor cells.
These progenitor cells have evolved into glial cells that helped to repair damage to the damaged area. Gli cells also strengthened the connection between neurons, which allowed neurons to continue sending signals. The substance P attracts therefore progenitor cellswould prevent injured tissue in dying, and it is one method used by the brain to recover from trauma.
After injury, the body needs a way to attract progenitor cells to the site of the injury. Progenitor cells are formed in the bone marrow, but pass through the bloodstream. This signal is often carried out by chemicals called cytokines, such as a factor-1 derived from Stromal (SDF-1).
cells at the site of damage release SDF-1 and direct progenitor cells to the bloodstream. Circulating progenitor cells strive for higher SDF-1 concentrations, leading to the locality of the injury. Once there are other growth factors, they will say progenitor cells that are needed, and the progenitors are properly distinguished.