What Is the Tryptophan Operon?

The tryptophan operon is an important operon. It is a group of genes that are used or transcribed together. It is also one of the elements used to encode tryptophan. The tryptophan operon is present in many bacteria, but was first characterized in E. coli. When sufficient tryptophan is present in the environment, it will not be used. This is an important experimental system for studying gene regulation, and is often used to teach the knowledge of gene regulation.

Tryptophan operon

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Tryptophan operon is an important

The E. coli tryptophan operon has a simpler structure and is the most clearly studied operon. The structural genes are arranged in sequence as trpEDC2BA.

The Trp synthesis pathway is relatively long and consumes a lot of energy and precursors, such as serine, PRPP, glutamine, etc., is one of the most expensive metabolic pathways in the cell, so it is strictly regulated. Among them

Due to the regulation of the tryptophan operon, high-yield Trp strains cannot exist in nature. In order to obtain high-yield Trp strains, the

In 1991, Bailey used metabolic engineering to describe the genetic manipulation of the cell's enzymatic reaction, material transport, and regulatory functions using DNA recombination technology, and then to improve the process of cell biological activity, marking the turning point of the development of metabolic engineering to a systematic discipline. Metabolic engineering is also called pathway engineering to distinguish it from traditional single-gene expression (first-generation genetic engineering) and gene-directed mutation (

check s Make up Transcription (bacterial, eukaryotic)
Transcriptional regulation	Prokaryotic Operators (lactose operon, tryptophan operon , galactose operon) · Repressors (lactose repressor, tryptophan repressor) Eukaryotic Histone modification enzymes (histone / nucleosomes): histone methylation / histone methyltransferase (EZH2) · histone demethylase · histone acetylation and deacetylation (histone deacetylation) HDAC1 · histone acetyltransferase) DNA methylation (DNA methyltransferase) Chromatin Remodeling: CHD7 Both Transcriptional co-regulators (co-activators, co-repressors) · inducers
start up	Promoter (Pribno box, TATA box, BRE, CAAT box, response element) · Enhancer (E-box, response element) · Insulator · Silencer
Onset (bacteria, Eukaryotic)	Transcription initiation site
extend	Bacterial RNA polymerase: rpoB Eukaryotic RNA polymerase: RNA polymerase II
Termination (bacteria, (Eukaryotic)	Terminator · Internal termination · factor
See also: Transcription and Post-Transcriptional Modification Diseases <br /> Biochemistry: Protein Biosynthesis: Regulation of Gene Expression (Cell Cycle Proteins, Oncogenes) · Transcription (nucleic acids, RNA, transcription factors and intracellular receptors, repeat sequences, post-transcription Modification) · translation (ribosomal subunit, ribonucleoprotein) · ubiquitin cross-linking enzyme · sorting protein · molecular chaperone · structure (protein domain, 1 °, 2 °, 2 °, 3 °, 4 °)