What Is a Platelet Plug?

Low platelet refers to the low level of platelets in human blood. Platelets are derived from the cytoplasm of mature megakaryocytes in the bone marrow. Each megakaryocyte can produce 2000 to 7000 platelets. A healthy person produces about 120 billion platelets per day.

Low platelets

This entry lacks an overview map . Supplementing related content makes the entry more complete and can be upgraded quickly. Come on!

Low platelet refers to the low level of platelets in human blood. Platelets are made of

distributed

The average platelet distribution is

Reduced platelet production

(1) Hereditary: such as Fanconi anemia, congenital malformations without megakaryocyte thrombocytopenia, and May-Hegglin abnormalities.

(2) Acquired: Aplastic anemia, bone marrow infiltration (malignant tumor bone marrow metastasis, leukemia, myelofibrosis, tuberculosis), chemotherapy drugs, radiation, megakaryocyte aplastic disorder, viral infection (measles, mumps), effects Platelet-producing drugs (such as alcohol), vitamin B ₁₂ , and folic acid deficiency.

Low platelet non-immune factor

Increased platelet destruction caused by non-immune factors

Thrombotic thrombocytopenic purpura, pregnancy, infection, hemangio-thrombocytopenia syndrome, snake bite, acute respiratory distress syndrome, severe burns, etc.

Platelet low immune factor

Increased platelet destruction

Immune thrombocytopenic purpura, HIV infection, periodic thrombocytopenia, drug-induced thrombocytopenia (heparin, quinine, quinidine, antipyretic analgesics, penicillin, cephalosporin antibiotics, rifampicin, furosemide, Carbamazepine, sodium valproate, sulfonylurea hypoglycemic agents, phenytoin sodium, etc.), thrombocytopenia after blood transfusion.

Low platelet retention in the spleen

Hypersplenism causes the spleen to retain platelets and reduce the number of platelets in the blood ^[2] . For example, Gaucher disease is often secondary to hypersplenism, and patients have a tendency to bleed due to thrombocytopenia caused by hypersplenism, which often manifests as fatigue, prone to bruising and nosebleeds ^[3] . In the ICGG report, 56% of patients with Gaucher disease worldwide have thrombocytopenia ^[4] . Some children may also develop anemia, which may be caused by shortened red blood cell life caused by hypersplenism. Gaucher disease is a lack of glucocerebrosidase activity in the body due to mutations in the glucocerebrosidase gene, causing its substrate glucocerebrosidase to be in the liver, spleen, bone, lung, and even brain macrophage lysosome An autosomal recessive hereditary disease in storage. The clinical manifestations are multiple organ involvement, which is progressive and life-threatening. Patients can be diagnosed by testing for glucocerebrosidase activity ^{[1] [5]} .