What Is Biochemical Pharmacology?

Biochemical pharmacology has always been an important area to explore the biochemical and molecular biological mechanisms of drugs on various targets. Chinese medicine, western medicine, biochemical and bioengineering drugs, marine drugs, and other drugs, although the sources and forms are different, all act on specific targets in the body to produce a therapeutic effect.

Biochemical pharmacology

Biochemical pharmacology has always been an important area to explore the biochemical and molecular biological mechanisms of drugs on various targets. Chinese medicine, western medicine, biochemical and bioengineering drugs, marine drugs, and other drugs, although the sources and forms are different, all act on specific targets in the body to produce a therapeutic effect.

Book title

Biochemical pharmacology

Author

Pan Jiayu

ISBN

9787309038804 ^[1]

Title: Biochemical Pharmacology

Book Number: 1003927

Publisher: Fudan University Press

Price: 30.0

ISBN: 730903880

Author: Pan Jia Hu

Publication date: 2004-09-01

Edition: 1

Folio: 16

Biochemical

1 Receptor pharmacology

1.1 Introduction

1.1.1 A Brief History of Receptor Research

1.1.2 Some basic concepts related to receptors

1.1.3 Receptor characteristics

1.1.4 Research significance of receptor pharmacology

1.2 Receptor nomenclature

1.2.1 Basic requirements for receptor naming

1.2.2 Receptor nomenclature

1.3 Classification of receptors

1.3.1 G protein-coupled receptors

1.3.2 Ligand-gated ion channel receptors

1.3.3 Enzyme active receptor

1.3.4 nuclear receptors

1.3.5 Orphan Receptor

1.4 Endogenous ligands

1.5 Molecular mechanism of the receptor

1.5.1 Receptor Localization

1.5.2 Receptor activation

1.5.3 Binding to Ligand

1.5.4 Receptor-Mediated Signaling

1.6 Regulation of the receptor

1.6.1 Some basic concepts of receptor regulation

1.6.2 Modes of receptor regulation

1.7 Receptor Kinetics

1.7.1 Concentration-response curve and receptor occupation theory

1.7.2 Competitive Interaction

1.7.3 Non-competitive interactions

1.7.4 Estimates of pD 2, pA 2 and pD 2

1.8 Methods of Studying Receptors

1.8.1 Determination of receptor structure and function

1.8.2 Detection of receptor activity

1.9 Monographs on Receptor Pharmacology

1.9.1 Pharmacology of adrenergic receptors-G protein coupled receptors

1.9.2 Pharmacology of Ligand-gated Ion Channel ReceptorsNMethyl DAspartate Receptors

1.9.3 Pharmacology of Interleukin-6 Receptor, Enzyme Active Receptor

1.9.4 Pharmacology of Nuclear ReceptorRetinoic Acid Receptor

1.10 Problems and Outlook

2 Ion channel pharmacology

2.1 Overview of ion channel research

2.2 Common characteristics and classification of ion channels

2.2.1 Common characteristics of ion channels

2.2.2 Classification of ion channels

2.3 Effect of drugs on ion channels

2.3.1 Mode of action

2.3.2 Status and Use Dependency

2.4 Commonly used drugs acting on ion channels

2.4.1 Drugs acting on Na + channels

2.4.2 Drugs acting on Ca 2+ channels

2.4.3 Drugs acting on K + channels

2.4.4 Drugs acting on transmitter-gated ion channels

2.5 Problems and Outlook

3 Free radical pharmacology

3.1 Definition and production of free radicals

3.1.1 Definition and properties of free radicals

3.1.2 Production of free radicals

3.2 Types and physical and chemical properties of free radicals

3.2.1 Oxygen free radicals

3.2.2 Free radicals formed by drug metabolism

3.3 Information transmission of oxygen free radicals

3.3.1 Oxygen Free Radicals and Biological Evolution

3.3.2 Oxygen Free Radicals and Regulation of Immune System Function

3.3.3 Active Oxygen Signaling Pathway

3.4 Oxidative stress and diseases caused by free radicals

3.4.1 Active oxygen-mediated pathological damage

3.4.2 Pathological damage to the body caused by free radicals produced by drug metabolism

3.4.3 Diseases Caused by Free Radicals

3.5 The body's defense mechanism against free radicals

3.5.1 Antioxidants

3.5.2 Antioxidant Vitamins

3.5.3 Small molecule antioxidants

3.5.4 Metal ion chelator

3.5.5 Metallothionein and Ceruloplasmin

3.5.6 Repair of biological macromolecules

3.6 Drugs that regulate oxygen free radicals

3.6.1 Antioxidants

3.6.2 Pro-oxidant drugs

3.7 Detection of oxygen free radicals and screening of antioxidants

3.7.1 Physical determination method

3.7.2 Chemical determination method

3.7.3 Screening of Natural Antioxidants

3.8 Problems and Outlook

4 Drug metabolism enzymes pharmacology

4.1 Introduction to Drug Metabolizing Enzymes

4.1.1 Definition

4.1.2 Substrate

4.1.3 Classification and Naming

4.1.4 Distribution of P450

4.1.5 Features of P450

4.1.6 Induction and inhibition of P450

4.1.7 Research Significance

4.2 CYP superfamily

4.2.1 CYP1 Family

4.2.2 CYP2 Family

4.2.3 CYP3 Family

4.3 Non-P450 enzymes

4.3.1 Butyrylcholinesterase

4.3.2 Alcohol dehydrogenase

4.3.3 Monoamine Oxidase

4.3.4 Transferases

4.4 Types of Drug Metabolism

4.4.1 Phase I reaction

4.4.2 Phase II reaction

4.5 Genetic Pharmacology of Drug Metabolizing Enzymes

4.5.1 Causes of Variations in Drug Metabolizing Enzymes

4.5.2 Genetic pharmacological polymorphisms of drug metabolism enzymes

4.5.3 Polymorphisms of acetylation metabolism

4.6 Research Methods for Drug Metabolizing Enzymes

4.6.1 Traditional genetics methods

4.6.2 Modern molecular biology research methods

4.6.3 Enzymatic and chemical determination

4.6.4 Detection of drug metabolism intermediates

4.7 Problems and Outlook

5 Antitumor pharmacology

5.1 Pharmacological Basis of Cancer Chemotherapy

5.1.1 Classification of Antitumor Drugs

5.1.2 Pharmacological action mechanism of antitumor drugs

5.1.3 Relationship between dose and effect of antitumor chemotherapy

5.1.4 Anti-tumor drug resistance mechanisms

5.2 Commonly Used Cancer Chemotherapy Drugs

5.2.1 Drugs affecting nucleic acid biosynthesis

5.2.2 Drugs affecting DNA structure and function

5.2.3 Drugs that interfere with the transcription process and prevent RNA synthesis

5.2.4 Drugs that inhibit protein synthesis and function

5.2.5 Drugs that regulate hormone balance in the body

5.3 Toxicity and combination of antitumor chemotherapy drugs

5.3.1 Toxicity of antitumor chemotherapy drugs

5.3.2 Combined application of anti-tumor chemotherapy drugs

5.4 Tumor immunotherapy and gene therapy

5.4.1 Cancer immunotherapy

5.4.2 Cancer gene therapy

5.5 Other types of antitumor drugs

5.5.1 Cell differentiation inducer

5.5.2 Apoptosis inducer

5.5.3 Tumor radiosensitizers

5.6 Research on New Targets of Antitumor Drugs

5.6.1 New cytotoxic antitumor drugs

5.6.2 Tyrosine kinase inhibitors

5.6.3 Cell cycle regulators

5.6.4 Tumor neovascularization inhibitor

5.6.5 Tumor resistance reversal agents

5.6.6 Telomerase inhibitor

5.7 Problems and Outlook

6 Antiviral pharmacology

6.1 Overview

6.1.1 Basic characteristics of viruses

6.1.2 Virus replication

6.1.3 Types of virus infection

6.1.4 Development of antiviral drugs

6.2 Common antiviral chemicals

6.2.1 Inhibition of virus binding to receptors or entry into cells

6.2.2 Inhibition of virus shelling

6.2.3 Inhibition of viral nucleic acid synthesis

6.2.4 Inhibition of viral protease activity

6.2.5 Viral protein modification inhibitors

6.2.6 Inhibiting virus release

6.2.7 Sulfated polysaccharide antiviral drugs

6.3 Gene therapy

6.3.1 Antisense Oligonucleotides

6.3.2 Ribozyme

6.3.3 Other antiviral gene expression technologies

6.4 Natural antiviral drugs

6.5 Immunotherapy

6.5.1 Interferon

6.5.2 Therapeutic vaccine

6.6 Outlook

7 Bioactive molecular pharmacology

7.1 Adenosine

7.1.1 Biosynthesis and Metabolism

7.1.2 Biological activity

7.1.3 Clinical Application

7.2 20-pentaenoic acid and 22-hexahexaenoic acid

7.2.1 Structure and origin

7.2.2 Biological activity

7.2.3 Clinical Application

7.3 Dehydroepiandrosterone

7.3.1 Structure and Synthesis

7.3.2 Biological activity

7.3.3 Clinical Application

7.4 Melatonin

7.4.1 Structure and Synthesis

7.4.2 Biological effects

7.4.3 MT Receptor and Its Signaling Mechanism

7.4.4 Clinical Application of MT

7.5 Nitric oxide

7.5.1 Nitric oxide and nitric oxide synthase

7.5.2 Biological effects of NO

7.5.3 Clinical Application of NO

7.6 Peptide Active Drugs

7.6.1 Overview of Several Classes of Peptide Active Drugs

7.6.2 Pharmacological effects of salmon calcitonin

7.6.3 Pharmacological effects of octreotide

7.6.4 Pharmacological effects of ghrelin

7.6.5 Mechanism of GHRP release from GH

7.7 Cell growth factor drugs

7.7.1 Types of Cell Growth Factors

7.7.2 Pharmacological effects of recombinant human epidermal growth factor

7.7.3 Pharmacological effects of recombinant human basic fibroblast growth factor

7.7.4 Pharmacological effects of recombinant human nerve growth factor

7.7.5 Pharmacological effects of platelet-derived growth factor

7.7.6 Pharmacological effects of other cell growth factors

7.8 Interferon drugs

7.8.1 Types of Interferon

7.8.2 Pharmacological effects of human interferon 2 a and human interferon 2 b

7.8.3 Pharmacological effects of human interferon gamma

7.9 Interleukins

7.9.1 Types and Characteristics of Interleukins

7.9.2 Pharmacological effects of interleukin 2

7.9.3 Pharmacological effects of interleukin 3

7.9.4 Pharmacological effects of interleukin 6

7.9.5 Pharmacological effects of interleukin 8

7.9.6 Pharmacological effects of recombinant human interleukin 11

7.10 Colony-stimulating factor drugs

7.10.1 Types of recombinant human colony-stimulating factor drugs

7.10.2 Pharmacological effects of recombinant human granulocyte colony-stimulating factor

7.10.3 Pharmacological effects of recombinant human granulocyte / macrophage colony-stimulating factor

7.11 Genetically Engineered Thrombolytic Drugs

7.11.1 Types of genetically engineered thrombolytic drugs

7.11.2 Pharmacological effects of recombinant staphylokinase

7.11.3 Pharmacological effects of recombinant human tissue plasminogen activator

7.12 Other genetically engineered drugs

7.12.1 A new immunosuppressantthe monoclonal antibody OKT 3 and its pharmacological effects

7.12.2 Recombinant human growth hormone and its pharmacological effects

7.12.3 Recombinant human bone morphogenetic peptone 2 and its pharmacological effects

7.13 Genetically engineered vaccines

7.13.1 Types of genetically engineered virus vaccines

7.13.2 Immune effect of recombinant hepatitis B surface antigen vaccine

7.13.3 Preventive effect of genetically engineered malaria vaccine

8 New biochemical pharmacological detection technology

8.1 Cell culture method

8.1.1 Cell proliferation and inhibition of proliferation

8.1.2 Cell-dependent specific cell lines

8.1.3 Method for measuring dose-response index of cell culture

8.1.4 Application

8.2 Immunoassay

8.2.1 Radioimmunoassay

8.2.2 Quantitative immunoradioassay

8.2.3 Enzyme-linked immunosorbent assay

8.2.4 Time-resolved fluorescent immunoassay

8.3 New immune detection sensors and their applications

8.3.1 Immune detection system

8.3.2 Immunoassay technology

8.3.3 Application

8.4 Piezoelectric quartz crystal biosensor and its application

8.4.1 Theoretical basis

8.4.2 New solid-phase technology

8.4.3 Application

8.5 Biospecific Interaction Analysis

8.5.1 Principles of Biospecific Interaction Analysis

8.5.2 Analytical instrument

8.5.3 Sensing Probe

8.5.4 Application

8.5.5 Outlook

8.6 DNA Microarray Technology

8.6.1 DNA microarray

8.6.2 Microarray Technology

8.6.3 Application of Microarray Technology

8.6.4 Outlook

Appendix 1 Pharmacological Targets (English)

Appendix 2 English-Chinese Biochemical Pharmacology Vocabulary